Expression of cytokeratin subtypes in intraepidermal malignancies: a guide for differentiation

Aslan, Figen; Demirkesen, Cüyan; Çağatay, Penbe; Tüzüner, Nükhet

doi:10.1111/j.1600-0560.2006.00466.x

Cited by 31 publications

(39 citation statements)

References 13 publications

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“…On the other hand, secondary disease has a poor prognosis with mortality rates from underlying neoplasms that may exceed 50%. 3,4 Previous studies have suggested that specific immunohistochemical markers may be useful in differentiating primary from secondary EMPD. Most studies agree that cytokeratin (CK) 7 is positive in both primary and secondary disease.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Histologically, EMPD shows intraepidermal aggregates of large pale-staining cells with pleomorphic nuclei, prominent nucleoli, and mitotic figures. 3 This disorder can be classified into 2 categories based on the presence of an underlying neoplasm. Primary EMPD is not associated with an underlying neoplasm, whereas secondary EMPD is associated with an underlying visceral malignancy.…”

Section: Introductionmentioning

confidence: 99%

“…2 Other studies suggest that primary EMPD shows BRST-2-positive and CK20-negative staining, whereas the reverse is true for secondary EMPD (BRST-2 negative and CK20 positive). 2,3 Our goal was to determine if there are any reliable stains that distinguish primary from secondary EMPD by analyzing a large series of patients with EMPD with an expanded immunohistochemical panel.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Role of Immunohistochemistry in Discriminating Primary From Secondary Extramammary Paget Disease

Perrotto¹,

Abbott²,

Ceilley³

et al. 2010

The American Journal of Dermatopathology

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The role of CK7, CK20, and BRST-2 in distinguishing primary and secondary EMPD is limited because CK20 and BRST-2 were positive in large subsets of both groups. An expanded immunohistochemical panel, including HER-2/neu and CDX2, may be useful in discriminating primary EMPD from EMPD secondary to anorectal adenocarcinoma but fails to distinguish primary EMPD from EMPD secondary to urothelial or prostatic malignancy. The consistent overexpression of HER-2/neu in primary EMPD suggests a role for trastuzumab therapy in patients with recurrent disease.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Role of Immunohistochemistry in Discriminating Primary From Secondary Extramammary Paget Disease

Perrotto¹,

Abbott²,

Ceilley³

et al. 2010

The American Journal of Dermatopathology

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“…This finding suggested that clear cell SCC (associated with Bowen's disease) basically has the characteristics of an SCC of the interfollicular epidermis. 22,23 Moreover, CK17 expression was generally negative, with only partial expression for the studied clear cell SCCs. In addition, a lack of CD34 expression was consistently seen in these clear cell SCCs.…”

Section: Discussionmentioning

confidence: 98%

Tricholemmoma and Clear Cell Squamous Cell Carcinoma (Associated With Bowen's Disease)

Misago

Toda

Narisawa

2012

The American Journal of Dermatopathology

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There have been only a few reported comparative immunohistochemical studies of normal hair follicles and tricholemmomas. Clear cell squamous cell carcinomas (SCCs), which are derived from Bowen's disease, histopathologically mimic or are difficult to distinguish from tricholemmal carcinoma. The purpose of and methods used in the present study are as follows: (1) evaluation of whether the immunohistochemical profile (cytokeratin (CK)1, CK10, CK17, CD34, and D2-40) in normal hair follicles is retained in tricholemmomas (11 lesions); and (2) a study of the immunohistochemical profile of in situ or superficially invasive clear cell SCCs (associated with Bowen's disease) (10 lesions) to investigate the presence or absence of tricholemmal differentiation markers in these lesions. The present study demonstrated that (1) the immunohistochemical profile of the normal outer root sheath cells was generally retained in tricholemmomas; (2) in contrast to the D2-40 expression in tricholemmomas (only a peripheral pattern, which is similar to that in the normal outer root sheath), the CD34 expression in tricholemmomas represented in a diffuse pattern, a peripheral pattern, and a combined diffuse and peripheral pattern; (3) tricholemmomas are benign neoplasms with outer root sheath (below the isthmus) differentiation, which characteristically show upregulation of CD34 expression with some functionally similar conditions to the terminal hair follicles in the anagen phase; and (4) there is no clear immunohistochemical evidence of tricholemmal differentiation in clear cell SCC (associated with Bowen's disease).

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“…[4] Finally, pISM present follicular involvement. [5] Contrary to EMPD, pBD cells stain positive for Ck10 but negative for CEA and Ck7; and pISM are S-100 and HMB-45 positive but negative for CK7 and CK10. EMPD cells stain positive for CEA and Ck7, and negative S-100 protein, Ck10.…”

Section: Empdmentioning

confidence: 89%

Ectopic extramammary Paget′s disease on the face

Ximena¹,

Puerto²,

Pérez³

et al. 2012

Indian J Dermatol Venereol Leprol

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Expression of cytokeratin subtypes in intraepidermal malignancies: a guide for differentiation

Abstract: An immunohistochemical panel may provide significant hints on the differentiation of common intraepidermal malignancies, especially in problematic cases.

Cited by 31 publications

References 13 publications

The Role of Immunohistochemistry in Discriminating Primary From Secondary Extramammary Paget Disease

The Role of Immunohistochemistry in Discriminating Primary From Secondary Extramammary Paget Disease

Tricholemmoma and Clear Cell Squamous Cell Carcinoma (Associated With Bowen's Disease)

Ectopic extramammary Paget′s disease on the face

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