Ectopic extramammary Paget′s disease on the face

Ximena, Echeverría; Puerto, Constanza del; Pérez, Mario; González, Sergio

doi:10.4103/0378-6323.102385

Cited by 4 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 8 ] Radiotherapy, medical therapy with 5-FU, bleomycin, and CO 2 laser ablation are other modes of treatment. [ 8 9 ] Imiquimod used topically for a localized lesion of EMPD has shown promising results with 8-16 weeks of therapy with lifelong follow-up. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Extra mammary Paget′s disease: A rare case report

2015

View full text Add to dashboard Cite

Extramammary Paget's disease is a marginated plaque resembling Paget's disease but occurring in anogenital area, axilla or most commonly on the vulva. A 62-year-old postmenopausal woman presented with extremely pruritic plaque on the perineal skin which progressed gradually over 3 years and did not respond to any topical/systemic steroids, antibiotics, and antifungals. Examination revealed 7 × 8 cm. hypertrophic, verrucous plaque with erosions, and crusts at places. There was no evidence of visceral malignancy. Biopsy showed Paget's cells which were positive for Periodic Acid Schiff and alcian blue stain. Surgical excision was done considering the premalignant potential.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Associated internal malignancy or a CEA with dermal and lymphatic infiltrate of EMPD have worse prognosis. [ 8 9 ]…”

Section: Discussionmentioning

confidence: 99%

Extra mammary Paget′s disease: A rare case report

2015

View full text Add to dashboard Cite

show abstract

“…Extramammary Paget's disease (EMPD) is a malignant neoplasm with a predilection for the apocrine‐rich skin; due to this, the apocrine gland has been proposed as its origin . EMPD of the axilla is infrequent, and it has been reported only in few clinical cases …”

mentioning

confidence: 99%

“…The latter expands from an underlying malignancy . Although PD and EMPD share histological morphology, their association with neoplasms is different, and while almost 100% of PD cases present internal neoplasm, the association of EMPD with internal neoplasms is 16–48% …”

mentioning

confidence: 99%

“…The presence of a nodule on the primary lesion, clinically palpable lymph nodes, level of tumor invasion, and lymph node metastases were found to be the most important prognostic factors for this disease . The best choice of treatment is surgery; medical therapies including topical 5‐fluorouracil, bleomycin, 5% imiquimod, CO 2 laser ablation, photodynamic therapy, and radiotherapy have variable results …”

mentioning

confidence: 99%

See 1 more Smart Citation

Recurrent extramammary Paget's disease with an unusual histopathological finding

Peña-Romero¹,

Domínguez‐Cherit²,

Saeb‐Lima³

2015

Int J Dermatology

View full text Add to dashboard Cite

Perineal Paget's disease: A rare disorder and review of literature

Carbotta

Sallustio

Prestera

et al. 2016

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

IntroductionExtramammary Paget's disease (EMPD) occurs commonly in perineum, vulva and perineal region and is considered as a complex disorder due to different clinical and histological features.Presentation of caseA 61 years old woman had a dermatologic evaluation for anal itch and underwent a skin biopsy with diagnostic of Paget disease in perianal region. Pelvic magnetic resonance showed a huge tumor which involved skin, derma and gluteus and she firstly refused any surgical treatment. One year later, because of increasing of the tumor and bleeding, she underwent the surgical procedure with a complete excision, resection of the skin of the anus, inguinal lymphadenectomy and left colostomy. Because of lymph nodes metastasis, a VLS Miles was sequentially performed. She started oncological follow up that showed liver, lung and pelvic metastasis. She survived for 24 months after surgery.DiscussionIn literature, less than 200 cases of perineal Paget's disease have been reported. EMPD in some cases has an associated adenocarcinoma, which has been associated with a worse prognosis and high mortality. Wrong diagnosis and a superficial consideration of a benign evolution should be considered as the first mistake in clinical practice.ConclusionOur surgical approach is considered in literature as the best one for those cases, followed by the oncological treatment. Those patients need to be better studied and more attention should be paid to the clinical presentation.

show abstract

Ectopic extramammary Paget′s disease on the face

Cited by 4 publications

References 6 publications

Extra mammary Paget′s disease: A rare case report

Extra mammary Paget′s disease: A rare case report

Recurrent extramammary Paget's disease with an unusual histopathological finding

Perineal Paget's disease: A rare disorder and review of literature

Contact Info

Product

Resources

About