Expression of Cystic Fibrosis Transmembrane Conductance Regulator in Ganglia of Human Gastrointestinal Tract

Xue, Ruiqi; Gu, Huan; Qiu, Yamei; Guo, Yong; Korteweg, Christine; Huang, Jin; Gu, Jiang

doi:10.1038/srep30926

Cited by 30 publications

(26 citation statements)

References 65 publications

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“…Notably, CF could affect the brain itself: after CFTR mRNA was found in the hypothalamus -the very center of energy balance regulation feedback loops -its expression and the presence of the protein product were confirmed in the neurons throughout the brain [23] and in the ganglia of the gut [24], raising the possibility that CF affects the development and the function of the brain, as well as the gut-brain axis.…”

Section: Discussionmentioning

confidence: 99%

Circulating brain-derived neurotrophic factor, leptin, neuropeptide Y, and their clinical correlates in cystic fibrosis: a cross-sectional study

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Szczepanik

Trypuć

et al. 2020

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Introduction: Cystic fibrosis (CF) involves chronic inflammation and decreased pulmonary function, which increase caloric demand. Yet, sufficient energy provision is hindered by reduced appetite and fat malabsorption. Brain-derived neurotrophic factor (BDNF), leptin, and neuropeptide Y (NPY) belong to energy balance-regulating factors. We aimed to assess their concentrations in CF patients in order to search for potential clinical correlates. Material and methods: This was an exploratory, cross-sectional study. Patients' weight and height Z-scores, forced expiratory volume in 1 s (FEV 1 %), exocrine pancreatic status (fecal elastase-1), genotypes, and other characteristics were assessed. Serum concentrations of BDNF, leptin, NPY, IL-6, and TNF-α were measured using ELISA. Results: The study enrolled 56 patients, of whom 29 (52%) were female and 17 (30%) were younger than 16 years. Median (1 st-3 rd quartile) mass Z-score was-0.85 (-1.56-(-0.36)); median FEV 1 was 70.5% (45.0-89.5); 48 (86%) patients had exocrine pancreatic insufficiency and 8 (14%) diabetes. Overall, median concentrations were: BDNF: 33.91 ng/ml (26.40-40.43), leptin: 12.05 ng/ml (8.93-17.77), NPY: 2.86 ng/ml (1.75-4.42). None of these factors correlated with mass Z-score, FEV 1 %, IL-6 or TNF-α. Leptin and NPY correlated negatively (ρ =-0.62, p = 3 × 10-7); BDNF/NPY ratio was associated with leptin (ρ = 0.54, p = 2 × 10-5), BDNF/leptin ratio correlated with NPY (ρ = 0.60, p = 1 × 10-6). In a multivariable regression analysis NPY was weakly, but independently, associated with FEV 1 %, and leptin with age. Conclusions: BDNF and leptin were not associated with weight Z-score or FEV 1 %. Serum NPY concentrations seemed to be lower in CF patients with reduced pulmonary function independently of malnutrition and inflammation.

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Section: Discussionmentioning

confidence: 99%

Circulating brain-derived neurotrophic factor, leptin, neuropeptide Y, and their clinical correlates in cystic fibrosis: a cross-sectional study

Nowak

Szczepanik

Trypuć

et al. 2020

aoms

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“…; however, its role in these cellular types remains yet unclear [ 23 ]. Studies concerning in situ hybridization highlighted CFTR expression in human neurons from the central nervous system, including the brain and spinal cord [ 24 , 25 , 26 , 27 , 28 ], and in human neurons within the peripheral neuronal systems, especially in cells of the sympathetic and parasympathetic networks of the enteric system [ 27 ]. The task of the enteric system is to connect the digestive and intestinal traits with the central system.…”

Section: Psychological Symptoms and Neuronal Impairment In Cfmentioning

confidence: 99%

Impact of Physical Activity on Cognitive Functions: A New Field for Research and Management of Cystic Fibrosis

et al. 2020

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Cystic Fibrosis (CF) is a genetic disease inherited by an autosomal recessive mechanism and characterized by a progressive and severe multi-organ failure. Mutations in Cystic Fibrosis Conductance Regulator (CFTR) protein cause duct obstructions from dense mucus secretions and chronic inflammation related to organ damage. The progression of the disease is characterized by a decline of lung function associated with metabolic disorders and malnutrition, musculoskeletal disorders and thoracic deformities, leading to a progressive decrement of the individual’s quality of life. The World Health Organization (WHO) qualifies Physical Activity (PA) as a structured activity produced by skeletal muscles’ movements that requires energy consumption. In the last decade, the number of studies on PA increased considerably, including those investigating the effects of exercise on cognitive and brain health and mental performance. PA is recommended in CF management guidelines, since it improves clinic outcomes, such as peripheral neuropathy, oxygen uptake peak, bone health, glycemic control and respiratory functions. Several studies regarding the positive effects of exercise in patients with Cystic Fibrosis were carried out, but the link between the effects of exercise and cognitive and brain health in CF remains unclear. Animal models showed that exercise might improve learning and memory through structural changes of brain architecture, and such a causal relationship can also be described in humans. Indeed, both morphological and environmental factors seem to be involved in exercise-induced neural plasticity. An increase of gray matter volume in specific areas is detectable as a consequence of regular training in humans. Neurobiological processes associated with brain function improvements include biochemical modifications, such as neuromodulator or neurohormone release, brain-derived neurotrophic factor (BDNF) production and synaptic activity changes. From a functional point of view, PA also seems to be an environmental factor enhancing cognitive abilities, such as executive functions, memory and processing speed. This review describes the current state of research regarding the impacts of physical activity and exercise on cognitive functions, introducing a possible novel field of research for optimizing the management of Cystic Fibrosis.

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“…The ENS is the intrinsic nervous system of the gastrointestinal tract and is composed of the myenteric and the submucosal plexuses, which are integrated in the wall of the gastrointestinal tract. The ENS is connected to the CNS through sympathetic and parasympathetic nerves, and regulates several functions among which are included motility, glandular secretions, fluid transport, or local blood flow (Xue et al, 2016 ).…”

Section: Extracellular Adenosine: Sources and Receptorsmentioning

confidence: 99%

Adenosine: Direct and Indirect Actions on Gastric Acid Secretion

et al. 2017

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Composed by a molecule of adenine and a molecule of ribose, adenosine is a paradigm of recyclable nucleoside with a multiplicity of functions that occupies a privileged position in the metabolic and regulatory contexts. Adenosine is formed continuously in intracellular and extracellular locations of all tissues. Extracellular adenosine is a signaling molecule, able to modulate a vast range of physiologic responses in many cells and organs, including digestive organs. The adenosine A1, A2A, A2B, and A3 receptors are P1 purinergic receptors, G protein-coupled proteins implicated in tissue protection. This review is focused on gastric acid secretion, a process centered on the parietal cell of the stomach, which contains large amounts of H+/K+-ATPase, the proton pump responsible for proton extrusion during acid secretion. Gastric acid secretion is regulated by an extensive collection of neural stimuli and endocrine and paracrine agents, which act either directly at membrane receptors of the parietal cell or indirectly through other regulatory cells of the gastric mucosa, as well as mechanic and chemic stimuli. In this review, after briefly introducing these points, we condense the current body of knowledge about the modulating action of adenosine on the pathophysiology of gastric acid secretion and update its significance based on recent findings in gastric mucosa and parietal cells in humans and animal models.

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Expression of Cystic Fibrosis Transmembrane Conductance Regulator in Ganglia of Human Gastrointestinal Tract

Cited by 30 publications

References 65 publications

Circulating brain-derived neurotrophic factor, leptin, neuropeptide Y, and their clinical correlates in cystic fibrosis: a cross-sectional study

Circulating brain-derived neurotrophic factor, leptin, neuropeptide Y, and their clinical correlates in cystic fibrosis: a cross-sectional study

Impact of Physical Activity on Cognitive Functions: A New Field for Research and Management of Cystic Fibrosis

Adenosine: Direct and Indirect Actions on Gastric Acid Secretion

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