Expression of cyclooxygenase-1 and 2 in chronic tonsillitis

Dılek, Fatma Hüsniye; Şahin, Önder; Tokyol, Çiğdem; Mazlum, Mustafa; Ayçiçek, Abdullah

doi:10.4103/0377-4929.68272

Cited by 5 publications

(6 citation statements)

References 21 publications

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Section: Clinical Consequences Of Cox Inhibition In Asthma and Othmentioning

confidence: 99%

“…In experimental allergic diseases, COX-2 regulates the development of T helper cell subsets [101–103]. Examination of tissue sections from patients with chronic tonsillitis show that activated B and T cells express both COX-1 and COX-2 [101]. Further studies will be necessary to elucidate the role of COX expression and/or function in immunologic responses in chronic tonsillitis [23].…”

Section: Clinical Consequences Of Cox Inhibition In Asthma and Othmentioning

confidence: 99%

“…COX-2-selective inhibitors also have efficacy similar to NSAIDs in other inflammatory arthropathies including ankylosing spondylitis and gout [123]; however, recent concerns about prothrombotic cardiovascular effects in humans have limited widespread use of COX-2 inhibitors [124]. COX-2 regulates the development T helper cell subsets in experimental models of allergic diseases [101–103]. Thus, COX-2 inhibitors may suppress inflammation through attenuation of T cell differentiation.…”

Section: Clinical Consequences Of Cox Inhibition In Asthma and Othmentioning

confidence: 99%

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Regulation of T helper cell subsets by cyclooxygenases and their metabolites

Edin

Gruzdev

et al. 2013

Prostaglandins & Other Lipid Mediators

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Cyclooxygenases and their metabolites are important regulators of inflammatory responses and play critical roles in regulating the differentiation of T helper cell subsets in inflammatory diseases. In this review, we highlight new information on regulation of T helper cell subsets by cyclooxygenases and their metabolites. Prostanoids influence cytokine production on both antigen presenting cells and T cells to regulate the differentiation of naïve CD4+ T cells to Th1, Th2 and Th17 cell phenotypes. Cyclooxygenases and PGE2 generally exacerbate Th2 and Th17 phenotypes, while suppressing Th1 differentiation. Thus, cycloxygenases may play a critical role in diseases that involve immune cell dysfunction. Targeting of cyclooxygenases and their eicosanoid products may represent a new approach for treatment of inflammatory diseases, tumors and autoimmune disorders.

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Section: Clinical Consequences Of Cox Inhibition In Asthma and Othmentioning

confidence: 99%

Section: Clinical Consequences Of Cox Inhibition In Asthma and Othmentioning

confidence: 99%

Section: Clinical Consequences Of Cox Inhibition In Asthma and Othmentioning

confidence: 99%

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Regulation of T helper cell subsets by cyclooxygenases and their metabolites

Edin

Gruzdev

et al. 2013

Prostaglandins & Other Lipid Mediators

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“…In Saudi Arabia, ovarian cancer is the seventh most common malignancy among females and accounting for 3.1% of all newly diagnosed cases with median age of 50 years [15]. Epithelial ovarian cancer accounts for 85-90% of total ovarian tumor [16]. …”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus genotyping and integration in ovarian cancer Saudi patients

Al‐Shabanah

Hafez

Hassan

et al. 2013

Virol J

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BackgroundHuman papillomavirus (HPV) is associated with different malignancies but its role in the pathogenesis of ovarian cancer is controversial. This study investigated the prevalence, genotyping and physical state of HPV in ovarian cancer Saudi patients.MethodsHundred formalin fixed paraffin embedded (FFPE) ovarian carcinoma tissues and their normal adjacent tissues (NAT) were included in the study. HPV was detected by nested polymerase chain reaction (PCR) using degenerated HPVL1 consensus primer pairs MY09/MY11 and GP5+/GP6 + to amplify a broad spectrum of HPV genotypes in a single reaction. The HPV positive samples were further genotyped using DNA sequencing. The physical state of the virus was identified using Amplification of Papillomavirus Oncogene Transcripts (APOT) assay in the samples positive for HPV16 and/or HPV18.ResultsHigh percentage of HPV (42%) was observed in ovarian carcinoma compared to 8% in the NAT. The high-risk HPV types 16, 18 and 45 were highly associated with the advanced stages of tumor, while low-risk types 6 and 11 were present in NAT. In malignant tissues, HPV-16 was the most predominant genotype followed by HPV-18 and -45. The percentage of viral integration into the host genome was significantly high (61.1%) compared to 38.9% episomal in HPV positive tumors tissues. In HPV18 genotype the percentage of viral integration was 54.5% compared to 45.5% episomal.ConclusionThe high risk HPV genotypes in ovarian cancer may indicate its role in ovarian carcinogenesis. The HPV vaccination is highly recommended to reduce this type of cancer.

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“…IL-IF 10 shares characteristics of the IL-l RA family, including key amino acid consensus sequences and a similar genomic structure (61-65). IL-IFIO mRNA is expressed in several tissue such as heart, placenta, fetal liver, spleen, thymus, and activated B cells of the human tonsil (66)(67)(68)(69)(70). The expression in a variety of immune tissues and similarity to IL-IRa suggest a role of IL-l FlO in the inflammatory response and host defense (52,(71)(72)(73).…”

Section: Il-38 (Il-lflo)mentioning

confidence: 99%

IL-36 Receptor Antagonist with Special Emphasis on IL-38

Shaik

Sabatino

Maccauro

et al. 2013

Int J Immunopathol Pharmacol

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IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NFκB pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro. IL-38 binds to IL-36 receptor as does IL-36RA and has similar biological effects on immune cells. IL-38 is also a member of IL-1 cytokine and shares some characteristics of IL-1RA, binding the same IL-1 receptor type I. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting protective effect in some autoimmune diseases. Both IL-38 and IL-36RA have an anti-inflammatory biological effect, however in some cases have contrary effects.

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Expression of cyclooxygenase-1 and 2 in chronic tonsillitis

Cited by 5 publications

References 21 publications

Regulation of T helper cell subsets by cyclooxygenases and their metabolites

Regulation of T helper cell subsets by cyclooxygenases and their metabolites

Human papillomavirus genotyping and integration in ovarian cancer Saudi patients

IL-36 Receptor Antagonist with Special Emphasis on IL-38

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