Expression of cyclo‐oxygenases‐1 and ‐2, and microsomal prostaglandin E synthase‐1 in penile and preputial papillomas and squamous cell carcinomas in the horse

Abstract

Expression of COX-1 and COX-2 in penile and preputial SCC in the horse is poor and COX inhibitors may thus be of little value for prevention or treatment. Microsomal PGES-1 is more prominently expressed in well-differentiated tissue compared with poorly differentiated tissue. Further research on the role of mPGES-1 in carcinogenesis is needed to assess its potential use as a treatment target. Knowledge of arachidonic pathway enzyme expression and their role in equine penile and preputial carcinogenesis may help in developing preventive and therapeutic strategies.

Molecular carcinogenesis in equine penile cancer: A potential animal model for human penile cancer

“…This is probably due, factors for survival and metastasis. In the present study 86% of the examined cases exhibited COX-2 immunoreaction which is in agreement with a previous study [28], but differs from another that reported only 50% of cases being positive with the majority showing less than 1% of immunoreactive neoplastic cells [21]. In these studies, correlation between COX-2 overexpression, tumor differentiation and MI was not analyzed or showed no statistical association.…”

Expression of mPGES1 and p16 in feline and human oral squamous cell carcinoma: A comparative oncology approach

“…22 However, Van den Top et al (2014) found that mPGES1 expression was higher in well-differentiated tissues compared to poorlydifferentiated lesions in a study of equine cutaneous papilloma and SCCs, indicating that mPGES1 does not always increase with evidence of malignancy. 21 It is also important to note that the adjacent epithelium evaluated in this study was in close proximity to invasive OSCC.…”

“…This is in contrast with a study showing that mPGES1 expression was significantly higher in canine and feline mammary carcinomas compared to adenomas and non‐neoplastic mammary tissues, 23 and another study showing that mPGES1 was more highly expressed in canine osteosarcoma compared to normal and reactive canine bone 22 . However, Van den Top et al (2014) found that mPGES1 expression was higher in well‐differentiated tissues compared to poorly‐differentiated lesions in a study of equine cutaneous papilloma and SCCs, indicating that mPGES1 does not always increase with evidence of malignancy 21 . It is also important to note that the adjacent epithelium evaluated in this study was in close proximity to invasive OSCC.…”

“…To date, mPGES1 expression has not been published in FOSCC. However, mPGES1 is expressed in cutaneous papillomas and SCCs of horses, 21 canine osteosarcoma 22 and canine and mammary feline cancer 23 . We expect that mPGES1 will be expressed in OSCC of cats as it is in humans.…”

Penistumoren bij het paard: een update

“…COX-2 promoot de synthese van prostaglandine E2, die op zijn beurt de angiogenese stimuleert en op die manier kan zorgen voor meer vorming van metastasen en een grotere invasiviteit van de tumor (Gately et al, 2003). Niettemin werd in een studie van van Den Top et al (2014) aangetoond dat de expressie van COX-1 en COX-2 in peniscarcinomen laag is en dat COX-inhibitoren dus mogelijk van weinig waarde zijn voor preventie of behandeling.…”