Expression of corticotrophin-releasing hormone and its receptor in patients with intrahepatic cholestasis of pregnancy

Zhang, Fan; He, Menghua; Liu, Z.F.; Zhang, L.; Gao, Bing; Wang, X.D.

doi:10.1016/j.placenta.2013.02.006

Cited by 12 publications

(11 citation statements)

References 24 publications

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“…Correlation analysis had shown that the correlations between the maternal serum UCN levels and these above indicators were not obvious. Our previously study indicated that CRH might play a key role in the mechanism causing the adverse pregnancy outcomes of ICP [23]. UCN and CRH may exert a synergistic effect in the mechanism of acute fetal distress in ICP.…”

Section: Discussionmentioning

confidence: 89%

Expression of urocortin and corticotrophin-releasing hormone receptor-2 in patients with intrahepatic cholestasis of pregnancy

Zhang

Sun

et al. 2014

Placenta

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Section: Discussionmentioning

confidence: 89%

Expression of urocortin and corticotrophin-releasing hormone receptor-2 in patients with intrahepatic cholestasis of pregnancy

Zhang

Sun

et al. 2014

Placenta

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“…However, the etiology of ICP is still poorly understood [12]. Recent studies have focused on the potential role of certain imbalance of immune reaction in the etiology of ICP [13], [14].…”

Section: Introductionmentioning

confidence: 99%

Roles of PPARγ/NF-κB Signaling Pathway in the Pathogenesis of Intrahepatic Cholestasis of Pregnancy

Zhang

Cui

et al. 2014

PLoS ONE

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BackgroundIntrahepatic cholestasis of pregnancy (ICP) is the most prevalent pregnancy specific liver disease. However, the pathogenesis and etiology of ICP is poorly understood.AimTo assess the expression of peroxisome proliferator-activated receptorγ (PPARγ) and nuclear factor kappa B (NF-κB) in placenta and HTR-8/SVneo cell, and evaluate the serum levels of cytokines, bile acids, hepatic function and lipids in control and ICP patients and the fetal outcome, in order to explore the role of PPARγ/NF-κB signaling pathway in the possible mechanism of ICP.MethodsClinical data of the pregnant women were collected and serum levels of cytokines, bile acids, hepatic function and lipids were measured. Expressions of PPARγ and NF-κB in placenta and HTR-8/SVneo cell were determined. The new-born information was collected to demonstrate the relationship between PPARγ/NF-κB signaling pathway and ICP.ResultsThe serum levels of bile acids, hepatic function, triglycerides (TG), total cholesterol (TC), IL-6, IL-12 and TNF-α in ICP group were significantly increased (P<0.01), and serum level of IL-4 was significantly decreased (P<0.01). PPARγ and NF-κB staining were found in the membrane and cytoplasm of placental trophoblast cell. The expression of PPARγ and NF-κB were significantly higher in ICP group and taurocholate acid (TCA) treated HTR-8/SVneo cell (P<0.01). The new-born information in severe ICP group were significantly different as compared to that in control group (P<0.05), and part of information in mild ICP group were also difference to that in control group (P<0.05).ConclusionsThe higher expressions of PPARγ and NF-κB in ICP placenta and TCA treated HTR-8/SVneo cell, together with the abnormal serum levels of cytokines, might induced by the imbalance of inflammatory and immune reaction, and then disturb placental bile acid and serum lipids transportation, finally result in fatal cholestasis which probably be one of the mechanism of ICP.

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“…HBV infection triggers an autoimmune response, and ultimately leads to hepatic cell damage. Moreover, specific hormone level changes during pregnancy can place extra burden on the liver and aggravate liver disease 7–9. HBV infection and ICP can affect the development of liver disease, but their relationship during pregnancy is not known.…”

Section: Introductionmentioning

confidence: 99%

The impact of intrahepatic cholestasis of pregnancy with hepatitis B virus infection on perinatal outcomes

Hu¹,

Ding²,

Yu³

2014

TCRM

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IntroductionTo investigate the impact of intrahepatic cholestasis of pregnancy (ICP) with hepatitis B virus (HBV) infection on perinatal outcomes.MethodsIn the study, 200 pregnant women were divided into four groups, including 50 cases with ICP and HBV infection, 50 cases with ICP, 50 cases with HBV infection, and 50 healthy pregnancies. The delivery process and perinatal outcomes were analyzed among different groups.ResultsWhen compared to the healthy pregnancy group, significantly increased rates of premature rupture of membranes, meconium-stained amniotic fluid, and cesarean section were observed in cases of ICP, HBV infection, or ICP patients with HBV (P<0.05). Specifically, the rates of HBV infection in the newborn, fetal distress, neonatal asphyxia, and birth defects in the newborn, and infant Apgar scores were higher in ICP pregnancies with HBV (56%, 48%, 16%, and 48%, respectively) than in the other groups (P<0.05).ConclusionICP combined with HBV infection has a clear influence on perinatal infant outcomes.

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Expression of corticotrophin-releasing hormone and its receptor in patients with intrahepatic cholestasis of pregnancy

Cited by 12 publications

References 24 publications

Expression of urocortin and corticotrophin-releasing hormone receptor-2 in patients with intrahepatic cholestasis of pregnancy

Expression of urocortin and corticotrophin-releasing hormone receptor-2 in patients with intrahepatic cholestasis of pregnancy

Roles of PPARγ/NF-κB Signaling Pathway in the Pathogenesis of Intrahepatic Cholestasis of Pregnancy

The impact of intrahepatic cholestasis of pregnancy with hepatitis B virus infection on perinatal outcomes

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