Expression of collagen type I in unaltered and osteoarthritic menisci of knee joint

Sladojević, Igor; Krivokuća, Zdenka; Gajanin, Vesna; Manojlović, Slavko

doi:10.2298/mpns1602016s

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Osteoarthritis (OA) is the most predominant degenerative joint disease [1]. It is characterized by chronic musculoskeletal pain which is related to physical disability and dysfunction [2].…”

Section: Introductionmentioning

confidence: 99%

Risk factors for hand osteoarthritis

et al. 2020

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Introduction. Hand osteoarthritis is a joint degenerative disease characterized by hand deformities affecting the hand strength and function, leading to greater disability and increased healthcare utilization. The objective of this study was to estimate the impact of different risk factors on the incidence of hand osteoarthritis. Material and Methods. The study was a prospective cross-sectional study conducted at the Special Hospital for Rheumatic Diseases Novi Sad, Serbia, during a one year period (2017 - 2018). It included 100 postmenopausal women aged 60 to 70 years presenting with pain in the hands ? 3 according to the visual analogue scale. All respondents were divided into two groups, according to radiographic findings graded using the Kellgren-Lawrence scale. Risk factors responsible for the development of hand osteoarthritis were examined and the research procedure included medical history data, physical examination of the hand joints, anthropometric measurements, and laboratory tests. Statistical processing and analysis was performed using Statistical Package for the Social Sciences ver. 25. Results. Statistically significant differences were found between the two groups in relation to positive family history of degenerative changes in the hand joints (p = 0.000), as well as in relation to metabolic syndrome (p = 0.001). Conclusion. A positive family history of degenerative changes of the hands and presence of metabolic syndrome are significant risk factors for the development of hand osteoarthritis.

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Section: Introductionmentioning

confidence: 99%

Risk factors for hand osteoarthritis

et al. 2020

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“…It is well established [1] that the structure of the meniscus aids it in transmitting load. The electrolyte content of the meniscus is estimated at 74% [5], with 80% of the remaining dry weight being Type 1 collagen [6]. Collagen fibres are oriented circumferentially in the deep layers of the meniscus, parallel to the meniscal border, with radial and axial oriented tie fibres branching from the peripheral border of the meniscus to its inner rim, surrounding the aforementioned circumferential fibres [1,7].…”

Section: Introductionmentioning

confidence: 99%

Proteoglycans exert a significant effect on human meniscal stiffness through ionic effects

Mahmood

Clarke

Riches

2020

Clinical Biomechanics

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BackgroundProteoglycans contribute to mechanical stiffness in articular cartilage, aiding load transmission. The magnitude of the ionic contribution of proteoglycans to the stiffness of human meniscal tissue has not been established. MethodsThirty-six discs of human meniscal tissue were placed within a custom confined compression chamber and bathed in three solutions of increasing ionic concentration. Following a 0.3N preload, at equilibrium, a 10% ramp compressive strain was followed by a 7200 second hold phase. A nonlinear poroviscoelastic model with strain dependent permeability was fitted to resultant stress relaxation curves. All samples were assayed for proteoglycan content. Model parameters were analysed using multivariate analysis of variance whilst proteoglycan content was compared using a univariate analysis of variance model. FindingsA significant difference (p<0.05) was observed in the value of the Young's modulus (E) between samples tested in deionised water compared to those tested in solutions of high ionic concentration. No differences were observed in the zero-strain permeability or the exponential strain dependent stiffening coefficient. Proteoglycan content was not found to differ with solution; but was found to be significantly increased in the middle meniscal region of both menisci. InterpretationProteoglycans make a significant ionic contribution to mechanical stiffness of the meniscus, increasing it by 58% in the physiological condition. It is therefore critical that meniscal regeneration strategies attempt to recreate the function of proteoglycans to ensure normal meniscal function.

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The inhibition of microRNA-203 on ischemic reperfusion injury after total knee arthroplasty via suppressing MYD88-mdiated toll-like receptor signaling pathway

Tian

Yu²,

et al. 2019

Gene

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Expression of collagen type I in unaltered and osteoarthritic menisci of knee joint

Cited by 4 publications

References 20 publications

Risk factors for hand osteoarthritis

Risk factors for hand osteoarthritis

Proteoglycans exert a significant effect on human meniscal stiffness through ionic effects

The inhibition of microRNA-203 on ischemic reperfusion injury after total knee arthroplasty via suppressing MYD88-mdiated toll-like receptor signaling pathway

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