Expression of CD44 (NKI-P1) in oral squamous cell carcinoma associated vascular endothelial cells: A relationship to tumor angiogenesis

Essa, Ahmed; Deraz, Elsayed Mohamed

doi:10.1016/j.sdentj.2021.09.022

Cited by 12 publications

(12 citation statements)

References 21 publications

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“… 47 CD44 is a transmembrane adhesion receptor for hyaluronan (HA) involved in both physiological and pathological processes, including cell adhesion, angiogenesis, inflammation, and tumor development. 48 Its critical role in cells undergoing EMT and acquiring stem-like characteristics has been well established. The transcription factors regulating EMT upregulate CD44, while the latter inversely regulates E-cadherin expression.…”

Section: Discussionmentioning

confidence: 99%

The interplay of EMT and stemness driving malignant transformation of Oral Submucous Fibrosis

Shetty,

Sharma,

Padam

et al. 2024

Journal of Oral Biology and Craniofacial Research

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Section: Discussionmentioning

confidence: 99%

The interplay of EMT and stemness driving malignant transformation of Oral Submucous Fibrosis

Shetty,

Sharma,

Padam

et al. 2024

Journal of Oral Biology and Craniofacial Research

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“…These new blood vessels often develop through dysregulation of a small subset of cytokines, specifically through upregulation of vascular endothelial growth factor (VEGF)-A and decreased expression of its inhibitor, thrombospondin-1 (TSP-1) [25]. Factors associated with angiogenesis, such as CD44, and blood microvessel density have correspondingly been reported to increase in oral cancer compared to normal epithelium [27].…”

Section: Inducing Angiogenesis In Oral Cancermentioning

confidence: 99%

“…(TSP-1) [25]. Factors associated with angiogenesis, such as CD44, and blood microvessel density have correspondingly been reported to increase in oral cancer compared to normal epithelium [27].…”

Section: Oral Cancer and Cellular Proliferationmentioning

confidence: 99%

Proliferation and Apoptosis Pathways and Factors in Oral Squamous Cell Carcinoma

Chakraborty

Ranganathan

2022

IJMS

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Oral cancer is the most common form of head and neck squamous cell carcinoma (HNSCC) and most frequently presents as oral squamous cell carcinoma (OSCC), which is associated with an alarmingly high mortality rate. Internationally, a plethora of research to further our understanding of the molecular pathways related to oral cancer is performed. This research is of value for early diagnosis, prognosis, and the investigation of new drugs that can ameliorate the harmful effects of oral cancer and provide optimal patient outcomes with minimal long-term complications. Two pathways on which the progression of OSCC depends on are those of proliferation and apoptosis, which overlap at many junctions. Herein, we aim to review these pathways and factors related to OSCC progression. Publicly available search engines, PubMed and Google Scholar, were used with the following keywords to identify relevant literature: oral cancer, proliferation, proliferation factors, genes, mutations, and tumor suppressor. We anticipate that the use of information provided through this review will further progress translational cancer research work in the field of oral cancer.

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“…As for other types of premalignant lesions, the number of vessels supplying OPMDs with a high risk of neoplastic transformation is generally higher than that present in the connective tissue underlying healthy oral mucosa [ 31 ]. Vessel density increases further in OSCCs, where it correlates positively with a low index of differentiation and/or with a high metastatic potential of the tumor [ 210 , 211 ], the second feature being consistent with the fact that the newly formed vessels also constitute new routes through which cancer cells may spread throughout the body [ 209 ]. The stimulation of angiogenesis occurring in high-risk OPMDs and OSCCs is paralleled by the concomitant overexpression of CD147, MMP-9, and VEGF [ 38 , 81 , 211 ].…”

Section: Cd147 and The Growth Of Osccmentioning

confidence: 99%

“…Vessel density increases further in OSCCs, where it correlates positively with a low index of differentiation and/or with a high metastatic potential of the tumor [ 210 , 211 ], the second feature being consistent with the fact that the newly formed vessels also constitute new routes through which cancer cells may spread throughout the body [ 209 ]. The stimulation of angiogenesis occurring in high-risk OPMDs and OSCCs is paralleled by the concomitant overexpression of CD147, MMP-9, and VEGF [ 38 , 81 , 211 ]. In fact, as is the case with MMP-9, the triggering of CD147 in cancer cells and peritumoral fibroblasts leads to the synthesis of VEGF ( Table 2 ), which is preceded by PI3K/AKT and MAPK signaling ( Figure 2 ) [ 53 ].…”

Section: Cd147 and The Growth Of Osccmentioning

confidence: 99%

The Multiple Roles of CD147 in the Development and Progression of Oral Squamous Cell Carcinoma: An Overview

Barillari

Melaiu

Gargari

et al. 2022

IJMS

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Cluster of differentiation (CD)147, also termed extracellular matrix metalloprotease inducer or basigin, is a glycoprotein ubiquitously expressed throughout the human body, the oral cavity included. CD147 actively participates in physiological tissue development or growth and has important roles in reactive processes such as inflammation, immunity, and tissue repair. It is worth noting that deregulated expression and/or activity of CD147 is observed in chronic inflammatory or degenerative diseases, as well as in neoplasms. Among the latter, oral squamous cell carcinoma (OSCC) is characterized by an upregulation of CD147 in both the neoplastic and normal cells constituting the tumor mass. Most interestingly, the expression and/or activity of CD147 gradually increase as healthy oral mucosa becomes inflamed; hyperplastic/dysplastic lesions are then set on, and, eventually, OSCC develops. Based on these findings, here we summarize published studies which evaluate whether CD147 could be employed as a marker to monitor OSCC development and progression. Moreover, we describe CD147-promoted cellular and molecular events which are relevant to oral carcinogenesis, with the aim to provide useful information for assessing whether CD147 may be the target of novel therapeutic approaches directed against OSCC.

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Expression of CD44 (NKI-P1) in oral squamous cell carcinoma associated vascular endothelial cells: A relationship to tumor angiogenesis

Cited by 12 publications

References 21 publications

The interplay of EMT and stemness driving malignant transformation of Oral Submucous Fibrosis

The interplay of EMT and stemness driving malignant transformation of Oral Submucous Fibrosis

Proliferation and Apoptosis Pathways and Factors in Oral Squamous Cell Carcinoma

The Multiple Roles of CD147 in the Development and Progression of Oral Squamous Cell Carcinoma: An Overview

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