Expression of CD44 and the pattern of CD44 alternative splicing in uveal melanoma

Danen, Erik H.J.; Berge, P.J.M. ten; Muijen, G.N.P. van; Jager, M. J.; Ruiter, Dirk J.

doi:10.1097/00008390-199602000-00005

Cited by 13 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22,28,[30][31][32][33][34][35] Our data are complimentary to observations that CD44s and isoforms are expressed in all in situ and superficially invasive bladder carcinomas, but progressively lost in deeply invasive bladder carcinomas 34 and that down-regulation of CD44s and v3, v5, v6 expression in prostatic carcinoma correlates with high tumour grade, aneuploidy, and distant metastasis. 33 Down-regulation of CD44 expression at both the mRNA and protein level also correlates with metastatic potential in the Dunning system of rat prostatic cancer sublines.…”

Section: Discussionsupporting

confidence: 84%

“…33 Down-regulation of CD44 expression at both the mRNA and protein level also correlates with metastatic potential in the Dunning system of rat prostatic cancer sublines. 35 CD44s expression appears to be a common feature of melanocytes in various organs, irrespective of malignancy, 6,18,19,22 contradicted by only one study with completely absent staining of CD44s in 65 cutaneous MMs. 20 CD44s appears to be preferentially expressed in epidermotropic metastases of MM, but diminished or absent in dermal and lymph node metastases.…”

Section: Discussionmentioning

confidence: 97%

“…19 CD44v10 was not expressed in SM, in contrast to 8/12 uveal MMs. 22 These discrepant observations could reflect different stages of local tumour invasion and/or phosphorylation of CD44, differences in the micro-environment of tumour cells, or epitope masking.…”

Section: Discussionmentioning

confidence: 99%

“…19 All uveal MMs stained strongly with CD44s, but only sporadic expression of CD44v5, v6, and v10 was observed, without correlation to prognostic parameters. 22 We investigated the distribution of CD44s and isoforms v5, v6, and v10 and a possible prognostic correlation in our archival collection of 14 primary mucosal melanomas of the nasal cavity and paranasal sinuses. 2…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

CD44 expression in sinonasal melanomas: is loss of isoform expression associated with advanced tumour stage?

et al. 1999

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

CD44 expression in sinonasal melanomas: is loss of isoform expression associated with advanced tumour stage?

et al. 1999

View full text Add to dashboard Cite

“…Danen and colleagues 102 reported that uveal melanomas that arise from retinal epithelium appear to express a diVerent CD44 pattern when compared with cutaneous melanomas. CD44v6 tends to be expressed by in situ uveal melanomas and not cutaneous melanomas and vice versa for CD44v5.…”

Section: Cd44 Expression In Malignant Melanomamentioning

confidence: 99%

The normal structure and function of CD44 and its role in neoplasia

Sneath

Mangham²

1998

Molecular Pathology

261

228

View full text Add to dashboard Cite

CD44 is a transmembrane glycoprotein, the variant isoforms of which are coded for by alternative splicing, with the most prolific isoform being CD44 standard. CD44 is found in a wide variety of tissues including the central nervous system, lung, epidermis, liver, and pancreas, whereas variant isoforms of CD44 (CD44v) appear to have a much more restricted distribution. Variants of CD44 are expressed in tissues during development, including embryonic epithelia. Known functions of CD44 are cellular adhesion (aggregation and migration), hyaluronate degradation, lymphocyte activation, lymph node homing, myelopoiesis and lymphopoiesis, angiogenesis, and release of cytokines. The functions of CD44 are principally dependant on cellular adhesion in one setting or another. The role of CD44 in neoplasia is less well defined, although metastatic potential can be conferred on non-metastasising cell lines by transfection with a variant of CD44 and high levels of CD44 are associated with several types of malignant tumours. The physiological functions of CD44 indicate that the molecule could be involved in the metastatic spread of tumours. Many studies have investigated the pattern of CD44 distribution in tumours and some observations suggest that certain cells do not use CD44 in tumorigenesis or in the production of metastases. However, the data are extremely conflicting, and further studies are needed to establish the prognostic value of CD44 and its variant isoforms. The precise function of CD44 in the metastatic process and the degree of involvement in human malignancies has yet to be established fully.

show abstract

Identification of Prognostic alternative splicing signatures and their clinical significance in uveal melanoma

Zhou

Fei

2021

Experimental Eye Research

View full text Add to dashboard Cite

Expression of CD44 and the pattern of CD44 alternative splicing in uveal melanoma

Cited by 13 publications

References 0 publications

CD44 expression in sinonasal melanomas: is loss of isoform expression associated with advanced tumour stage?

CD44 expression in sinonasal melanomas: is loss of isoform expression associated with advanced tumour stage?

The normal structure and function of CD44 and its role in neoplasia

Identification of Prognostic alternative splicing signatures and their clinical significance in uveal melanoma

Contact Info

Product

Resources

About