CD44 expression in sinonasal melanomas: is loss of isoform expression associated with advanced tumour stage?

Regauer, Sigrid; Ott, Arthur; Berghold, Andrea; Beham, Alfred

doi:10.1002/(sici)1096-9896(199901)187:2<184::aid-path216>3.0.co;2-2

Cited by 16 publications

(1 citation statement)

References 34 publications

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“…In unserem Patientengut fanden wir hinsichtlich der Expression von CD 44 s eine starke Anfärbung in den oberflächlichen Tumoranteilen und eine schwächere in den tieferen, aber im Gegensatz zur Pu-blikation von Harwood kein völliges Fehlen von CD 44 s in den invasiven Tumoranteilen und auch kein Fehlen von CD 44v5 und v6, jedoch eine deutliche Abnahme dieser Expression in den tieferen, infiltrierenden Tumoranteilen [23]. Diskutiert wird, ob eine Verminderung der Expression von CD 44 möglicherweise eine Rolle im biologischen Verhalten im Sinne einer Aggressivitätszunahme des Tumors spielt [23,30,41].…”

Section: Diskussionunclassified

Primäre sinunasale Melanome

Richtig

Regauer²,

Jakse³

et al. 2002

Der Hautarzt

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Section: Diskussionunclassified

Primäre sinunasale Melanome

Richtig

Regauer²,

Jakse³

et al. 2002

Der Hautarzt

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Melan‐A as a useful diagnostic immunohistochemical stain for the diagnosis of primary sinonasal melanomas

Snyder

Paulino

2001

Head & Neck

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CD44v6: a target for antibody-based cancer therapy

Heider

Kuthan

Stehle

et al. 2004

Cancer Immunology, Immunotherapy

144

116

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The human CD44 gene encodes type 1 transmembrane glycoproteins involved in cell-cell and cell-matrix interactions. The structural heterogeneity of the gene products is caused primarily by alternative splicing of at least 10 out of 20 exons. Certain CD44 variant isoforms, in particular those containing CD44 variant domain 6 (CD44v6), have been implicated in tumourigenesis, tumour cell invasion and metastasis. Here we will give an overview of immunohistochemically determined CD44v6 expression in human malignancies (primary epithelial and nonepithelial tumours as well as metastases) and normal tissues, and review several examples of the clinical use of CD44v6-specific antibodies. In nonmalignant tissues, CD44v6 expression is essentially restricted to a subset of epithelia. Intense and homogeneous expression of CD44v6 was reported for the majority of squamous cell carcinomas and a proportion of adenocarcinomas of differing origin, but was rarely seen in nonepithelial tumours. This expression pattern has made CD44v6 an attractive target for antibody-guided therapy of various types of epithelium-derived cancers.

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CD44 expression in sinonasal melanomas: is loss of isoform expression associated with advanced tumour stage?

Cited by 16 publications

References 34 publications

Primäre sinunasale Melanome

Primäre sinunasale Melanome

Melan‐A as a useful diagnostic immunohistochemical stain for the diagnosis of primary sinonasal melanomas

CD44v6: a target for antibody-based cancer therapy

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