Expression of CD10 by human T cells that undergo apoptosis both in vitro and in vivo

Increased Expression of the bcl6 and CD10 Proteins Is Associated with Increased Apoptosis and Proliferation in Diffuse Large B-Cell Lymphomas

“…Because a variety of cytokines may play a protective role in B-and T-cell apoptosis, CD10 expression may potentiate the apoptotic ability of B and T cells, by inhibiting the protective signals. As suggested by Cutrona et al (49), this could be consistent with the capacity of CD10 to hydrolyze a variety of active peptides, including growth and chemotactic factors. It is possible that CD10 participates in the process of selection in the germinal center and the thymus by increasing the threshold of cytokines required to prevent B and T-cell apoptosis, respectively.…”

“…Indeed, data from in vitro studies indicate that the role of bcl6 as promotor or inhibitor of apoptosis or proliferation may depend on the cellular context and the experimental approach (36 -46). In addition, in vitro studies and studies of normal lymphoid tissue and lymphoid malignancies showed that the expression of CD10 protein is associated with apoptosis and proliferation (4,5,10,(47)(48)(49)(50)(51). However, to the best of our knowledge, there is no detailed histological information about the relation of bcl6 and CD10 expression status with apoptosis and proliferation in diffuse large B-cell lymphomas.…”

“…CD10 and apoptosis it was suggested that CD10 might degrade cytokines that reach the cell when apoptosis has already started (49). Because a variety of cytokines may play a protective role in B-and T-cell apoptosis, CD10 expression may potentiate the apoptotic ability of B and T cells, by inhibiting the protective signals.…”

“…Indeed, (1) germinal center cells are characterized by high proliferation and have the propensity to undergo apoptosis and upregulate CD10 expression on apoptotic induction, whereas CD10 is absent on other subsets of mature B-cells that are not characterized by high apoptosis (47,48,51), (2) Burkitt's lymphoma cells that are characterized by high proliferation and apoptosis almost constantly express CD10 (4,5,10), and (3) CD10-positive B-acute lymphoblastic leukemia cells were cycling cells with elevated c-myc and propensity to apoptosis, whereas CD10-negative B-acute lymphoblastic leukemia cells had lower cycling capacities and c-myc levels and were resistant to apoptosis (50). Moreover, human postthymic and thymic T-cells express CD10 when undergoing apoptosis (49). To explain the relations between Chi-square tests: bcl6/CD10 patterns vs p53 (P ϭ 0.501), vs Rb (P ϭ 0.535), vs p16 (P ϭ 0.248), vs. p27 (P ϭ 0.351), vs bcl2 (P ϭ 0.240), vs cyclin A (P ϭ 0.502), vs cyclin B1 (P ϭ 0.062).…”

Identification of circulating CD10 positive T cells in angioimmunoblastic T-cell lymphoma

“…CD10 has been characterized as the neutral endopeptidase 24.11 and appears to play a functional role in promoting early T 22 and B cell 23 development as well as in regulating tumor T cell proliferation 24 and more recently in the regulation of the apoptotic process in T and B cells. 25,26 Cutrona et al 25 reported indeed that apoptotic T cells expressed CD10 and showed decreased CD3 expression. Thus, the aberrant CD10 expression in neoplastic T cells in AITL may be an indicator of disturbed apoptotic cell death.…”