Expression of Cathepsins B, D, and G in WHO Grade I Meningioma

Rahman, Rosanna; Schaijik, Bede van; Brasch, Helen D.; Marsh, Reginald; Wickremesekera, Agadha; Johnson, Rebecca; Woon, Kelvin; Tan, Swee T.; Itinteang, Tinte

doi:10.3389/fsurg.2019.00006

Cited by 11 publications

(9 citation statements)

References 51 publications

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“…Patulin also inhibited catalase activity [24]. Results published by Jin et al are in agreement with the above mentioned studies: patulin-induced hepatotoxicity develops in the mechanism of oxidative stress [25].…”

Section: Discussionsupporting

confidence: 79%

The influence of poisoning with patulin on activity of acid phosphatase, cathepsin B and D in mice kidneys and livers

Borzęcki¹,

Nieradko-Iwanicka²,

Mikocka³

2020

J Pre Clin Clin Res.

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Introduction. Patulin is a mycotoxin produced by a variety of moulds, for instance, Aspergillus, Penicillium and Byssochlamys, and found most often in rotten apples. Previous studies showed toxic effects of patulin in the gastro-intestinal tract, impairment of kidney function, as well as neurotoxicity. Objective. The aim of the study was to investigate whether intoxication with patulin affects the activity of acid phosphatase, cathepsin B and D in mice kidneys and livers. Materials and method. Experiments were conducted on 36 female mice. Animals were divided into 6 groups of 6: 1-control, 2-received 0.1 LD50 patulin i.p. 28 days, 3-saline i.p. once, 4-patulin i.p. 0.1 LD50 once, 5 patulin i.p. 0.2 LD50 once, 6patulin i.p. 0.5 LD50 once. 6 hours after patulin or saline administration, animals from groups 3, 4, 5, 6 were sacrificed. Kidneys and livers were obtained. Animals from groups 1 and 2 were sacrificed on day 29. Acid phosphatase activity was measured in the tissue supernatants with colorimetric method. Cathepsin B and D activities were determined with an ELISA-kit. Results. The activities of acid phosphatase, cathepsin B and D in the kidneys and livers of mice exposed to patulin for 28 days was higher than in controls. A proportionate increase in acid phosphatase and cathepsin B activity in the kidneys and livers was observed for a single dose of the xenobiotic. Conclusions. Acute and subacute poisoning with patulin negatively affects the functioning of lysosomes and induces an increase in the activity of lysosomal enzymes in mice livers and kidneys. Activities of acid phosphatase and selected cathepsins in the livers and kidneys are markers of cell damage due to patulin's toxicity.

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Section: Discussionsupporting

confidence: 79%

The influence of poisoning with patulin on activity of acid phosphatase, cathepsin B and D in mice kidneys and livers

Borzęcki¹,

Nieradko-Iwanicka²,

Mikocka³

2020

J Pre Clin Clin Res.

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“…Cathepsin G is a poor prognosticator [413] Glioblastoma Tissues Cathepsin G is expressed in the microvasculature [414] Meningioma Tissues Cathepsin G is expressed in the interstitium [359] Cathepsin D…”

Section: Tissues (↑)mentioning

confidence: 99%

Role of lysosomes in physiological activities, diseases, and therapy

Zhang¹,

Yue

et al. 2021

J Hematol Oncol

149

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Long known as digestive organelles, lysosomes have now emerged as multifaceted centers responsible for degradation, nutrient sensing, and immunity. Growing evidence also implicates role of lysosome-related mechanisms in pathologic process. In this review, we discuss physiological function of lysosomes and, more importantly, how the homeostasis of lysosomes is disrupted in several diseases, including atherosclerosis, neurodegenerative diseases, autoimmune disorders, pancreatitis, lysosomal storage disorders, and malignant tumors. In atherosclerosis and Gaucher disease, dysfunction of lysosomes changes cytokine secretion from macrophages, partially through inflammasome activation. In neurodegenerative diseases, defect autophagy facilitates accumulation of toxic protein and dysfunctional organelles leading to neuron death. Lysosomal dysfunction has been demonstrated in pathology of pancreatitis. Abnormal autophagy activation or inhibition has been revealed in autoimmune disorders. In tumor microenvironment, malignant phenotypes, including tumorigenesis, growth regulation, invasion, drug resistance, and radiotherapy resistance, of tumor cells and behaviors of tumor-associated macrophages, fibroblasts, dendritic cells, and T cells are also mediated by lysosomes. Based on these findings, a series of therapeutic methods targeting lysosomal proteins and processes have been developed from bench to bedside. In a word, present researches corroborate lysosomes to be pivotal organelles for understanding pathology of atherosclerosis, neurodegenerative diseases, autoimmune disorders, pancreatitis, and lysosomal storage disorders, and malignant tumors and developing novel therapeutic strategies.

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“…1). The cathepsins are expressed in several diseases, including keloid disorder [65,66], Dupuytren's disease [67], vascular tumors [68], vascular malformations [69] and benign and malignant solid tumors including meningioma [70], GB [71], metastatic colon adenocarcinoma to the liver [72], and cutaneous [73] and oral cavity [74] squamous cell carcinoma (SCC). Similarly, chymase-a ubiquitous serine protease with a strong ability to catalyze the formation of ATII, is found in many disorders [75].…”

Section: Bypass Loops Of the Rasmentioning

confidence: 99%