The renin-angiotensin system in central nervous system tumors and degenerative diseases

Haron, Simon; Kilmister, Ethan J.; Davis, Paul F.; Stylli, Stanley S.; Mantamadiotis, Theo; Kaye, Andrew H.; Hall, Sean; Tan, Swee T.; Wickremesekera, Agadha

doi:10.52586/4972

Cited by 6 publications

(2 citation statements)

References 160 publications

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“…The deleterious effects EV MetS , after neuronal RAS dysregulation towards the prooxidative/pro-inflammatory state, are consistent with previous studies showing the enhancing effect of AT1 overactivity on dopaminergic degeneration [16] and the neuroprotective effects of AT1 receptor blockers (ARBs) in cellular, animal [16] models of Parkinson s dis-ease, and clinical studies [57,58]. It is known that there are RAS receptors in different types of neurons, and that brain RAS is involved in different brain functions [19,76]. In addition, other recent studies have shown that adipose-tissue-derived EVs can be transferred to different neuron types such as hippocampal neurons [77].…”

Section: Discussionsupporting

confidence: 87%

Extracellular Vesicles and Their Renin–Angiotensin Cargo as a Link between Metabolic Syndrome and Parkinson’s Disease

Pedrosa,

Labandeira,

Lago-Baameiro

et al. 2023

Antioxidants

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Several studies showed an association between metabolic syndrome (MetS) and Parkinson’s disease (PD). The linking mechanisms remain unclear. MetS promotes low-grade peripheral oxidative stress and inflammation and dysregulation of the adipose renin–angiotensin system (RAS). Interestingly, brain RAS dysregulation is involved in the progression of dopaminergic degeneration and PD. Circulating extracellular vesicles (EVs) from MetS fat tissue can cross the brain–blood barrier and may act as linking signals. We isolated and characterized EVs from MetS and control rats and analyzed their mRNA and protein cargo using RT-PCR and the ExoView R200 platform, respectively. Furthermore, cultures of the N27 dopaminergic cell line and the C6 astrocytic cell line were treated with EVs from MetS rats. EVs were highly increased in MetS rat serum, which was inhibited by treatment of the rats with the angiotensin type-1-receptor blocker candesartan. Furthermore, EVs from MetS rats showed increased pro-oxidative/pro-inflammatory and decreased anti-oxidative/anti-inflammatory RAS components, which were inhibited in candesartan-treated MetS rats. In cultures, EVs from MetS rats increased N27 cell death and modulated C6 cell function, upregulating markers of neuroinflammation and oxidative stress, which were inhibited by the pre-treatment of cultures with candesartan. The results from rat models suggest EVs and their RAS cargo as a mechanism linking Mets and PD.

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Section: Discussionsupporting

confidence: 87%

Extracellular Vesicles and Their Renin–Angiotensin Cargo as a Link between Metabolic Syndrome and Parkinson’s Disease

Pedrosa,

Labandeira,

Lago-Baameiro

et al. 2023

Antioxidants

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“…c-Abl promotes cellular adhesion with a survival mechanism inside the cytoplasm, but it also induces cell death inside the mitochondria and nucleus ( Lindberg et al, 2015 ). Recent studies revealed that c-Abl is activated in response to amyloid beta fibrils and oxidative stress in AD and PD, as well as in animal models and neuronal cultures ( Haron et al, 2021 ).…”

Section: Common Targets Of Neurological Disordersmentioning

confidence: 99%

Natural product-based pharmacological studies for neurological disorders

Puri

Kanojia²,

Sharma³

et al. 2022

Front. Pharmacol.

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Central nervous system (CNS) disorders and diseases are expected to rise sharply in the coming years, partly because of the world’s aging population. Medicines for the treatment of the CNS have not been successfully made. Inadequate knowledge about the brain, pharmacokinetic and dynamic errors in preclinical studies, challenges with clinical trial design, complexity and variety of human brain illnesses, and variations in species are some potential scenarios. Neurodegenerative diseases (NDDs) are multifaceted and lack identifiable etiological components, and the drugs developed to treat them did not meet the requirements of those who anticipated treatments. Therefore, there is a great demand for safe and effective natural therapeutic adjuvants. For the treatment of NDDs and other memory-related problems, many herbal and natural items have been used in the Ayurvedic medical system. Anxiety, depression, Parkinson’s, and Alzheimer’s diseases (AD), as well as a plethora of other neuropsychiatric disorders, may benefit from the use of plant and food-derived chemicals that have antidepressant or antiepileptic properties. We have summarized the present level of knowledge about natural products based on topological evidence, bioinformatics analysis, and translational research in this review. We have also highlighted some clinical research or investigation that will help us select natural products for the treatment of neurological conditions. In the present review, we have explored the potential efficacy of phytoconstituents against neurological diseases. Various evidence-based studies and extensive recent investigations have been included, which will help pharmacologists reduce the progression of neuronal disease.

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Acupoint catgut embedding attenuates oxidative stress and cognitive impairment in chronic cerebral ischemia by inhibiting the Ang II/AT1R/NOX axis

Wei,

Ai,

et al. 2024

Pflugers Arch - Eur J Physiol

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The renin-angiotensin system in central nervous system tumors and degenerative diseases

Cited by 6 publications

References 160 publications

Extracellular Vesicles and Their Renin–Angiotensin Cargo as a Link between Metabolic Syndrome and Parkinson’s Disease

Extracellular Vesicles and Their Renin–Angiotensin Cargo as a Link between Metabolic Syndrome and Parkinson’s Disease

Natural product-based pharmacological studies for neurological disorders

Acupoint catgut embedding attenuates oxidative stress and cognitive impairment in chronic cerebral ischemia by inhibiting the Ang II/AT1R/NOX axis

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