2011
DOI: 10.1136/bjophthalmol-2011-300432
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Expression of cancer-testis antigens (MAGE-A1, MAGE-A3/6, MAGE-A4, MAGE-C1 and NY-ESO-1) in primary human uveal and conjunctival melanoma

Abstract: Uveal and conjunctival melanomas consistently expressed high levels of the differentiation antigens (gp100, Melan-A/MART1 and tyrosinase). However, compared with other tumours, including cutaneous melanoma, only low levels of CT antigens were found in ocular melanomas. These observations suggest that immunotherapy directly targeting the CT antigens studied may not be effective for ocular melanoma.

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Cited by 24 publications
(5 citation statements)
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“… 1,5,18 Furthermore, the overall mutational load is significantly lower 5 compared to CM 3 and expression of cancer-testis antigens is significantly rarer. 19 Consequently, the number and quality of (neo-)antigens presented to the immune system is likely to be different. Additionally, UM may rely on different immune escape mechanisms most clearly evidenced by the observation that higher numbers of infiltrating T-cells in the primary are linked to a worse outcome.…”
Section: Introductionmentioning
confidence: 99%
“… 1,5,18 Furthermore, the overall mutational load is significantly lower 5 compared to CM 3 and expression of cancer-testis antigens is significantly rarer. 19 Consequently, the number and quality of (neo-)antigens presented to the immune system is likely to be different. Additionally, UM may rely on different immune escape mechanisms most clearly evidenced by the observation that higher numbers of infiltrating T-cells in the primary are linked to a worse outcome.…”
Section: Introductionmentioning
confidence: 99%
“…Recurrences are associated with an increased risk of metastatic disease often unresponsive to conventional treatment. The mortality rate following the diagnosis of CM is 15% after 5 years and 30% after 10 years, with metastatic disease as the main cause of death [6]. Therefore, more effective treatments are needed in order to prevent local recurrence or the development of metastases.…”
Section: Introductionmentioning
confidence: 99%
“…MAGEA1 and MAGEB2 - are members of CT antigens; in particular, MAGEA1 was found expressed in 10% of cancer cells in conjunctival melanomas [31], and could be another candidate working in combination with immunotherapy;…”
Section: Resultsmentioning
confidence: 99%