Expression of Bcl-2, Bax, and p53 in high-grade prostatic intraepithelial neoplasia and localized prostate cancer: relationship with apoptosis and proliferation

Johnson, Mark; Robinson, Mary C.; Marsh, Colin; Robson, Craig; Neal, David E.; Hamdy, Freddie C.

doi:10.1002/(sici)1097-0045(19981201)37:4<223::aid-pros3>3.0.co;2-o

Cited by 77 publications

(37 citation statements)

References 41 publications

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“…However, con¯icting results have been reported for the incidence of bcl-2 immunoreactivity in high-grade prostatic intraepithelial neoplasia (PIN), which has been shown by several authors to be a precursor of prostatic adenocarcinoma [3,6±9]. In two studies strong bcl-2 immunoreactivity was observed in all foci of high-grade PIN [3,7] but in three studies, only 17±35% of high-grade PIN lesions were bcl-2 immunopositive [6,8,9]. However, there are no reports of the expression of bcl-2 protein in low-grade PIN.…”

Section: Introductioncontrasting

confidence: 48%

“…In the present study, bcl-2 immunoreactivity was detected in 12 of 15 high-grade PIN samples; in two other studies strong bcl-2 immunoreactivity in all high-grade PIN samples assessed [3,7] was reported, whereas in another three studies, only 17±35% of high-grade PIN lesions were bcl-2 positive [6,8,9]. This variation might be attributable to differences in the antibodies used and the relative preservation of antigen epitopes.…”

Section: Discussionmentioning

confidence: 99%

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Bcl‐2 proto‐oncogene expression in low‐ and high‐grade prostatic intraepithelial neoplasia

Baltacı¹,

Orhan

Özer³

et al. 2000

BJU International

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Objective To determine the incidence of bcl-2 protein expression in low-and high-grade prostatic intraepithelial neoplasia (PIN) lesions, and to explore the role of bcl-2 in prostatic tumorigenesis. Materials and methods Immunoreactivity for bcl-2 was examined in 10 samples of benign prostatic hyperplasia (BPH), 13 of primary prostatic adenocarcinoma, 15 of high-grade PIN and 18 of low-grade PIN.All immunostaining results were scored for the approximate percentage of positive tumour cells and relative immunostaining intensity (score range 0±12). Results In all BPH samples, bcl-2 staining was detected consistently in the basal cell layer of the ducts and acini, but no staining was ever apparent in luminal cells. The immunoreactivity for bcl-2 was heterogeneous in the prostatic carcinomas and bcl-2 protein expression was present in six samples. In these six bcl-2-positive tumours, the mean (range) staining score was 1.15 (1±6). There was detectable expression of bcl-2 in low-and high-grade PIN in all cell layers; immunoreactivity was present in 10 of 15 high-grade PIN lesions, with a mean (range) score of 1.14 (1±4), and in 12 of 18 samples of low-grade PIN, with a mean (range) score of 1.77 (1±6). Conclusions The high incidence of bcl-2 protein expression in low-and high-grade PIN lesions suggests that bcl-2 protein expression is associated with early prostate tumorigenesis.

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Section: Introductioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Bcl‐2 proto‐oncogene expression in low‐ and high‐grade prostatic intraepithelial neoplasia

Baltacı¹,

Orhan

Özer³

et al. 2000

BJU International

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“…YDPIN'lerde ise ikisinin arasında değerler almıştır. [19] Zellweger ve ark. [20] ise yaptıkları bir çalışmada BPH, PİN ve İDPCA'larda düşük Ki-67 labelling seviyesi tespit etmişlerdir (p<0.005).…”

Section: Discussionunclassified

“…Johnson ve ark. [19] YDPİN ve PCA'ları karşı-laştırdıkları bir çalışmada YDPİN'lerde bcl-2 boyanma oranını %34.9 olarak bildirmişlerdir. Ramos Soler ve ark.…”

Section: Discussionunclassified

Significance of Ki-67, BCL-2 and C-erbB2 markers in benign, premalign and malign prostatic lesions

Sayar¹,

Gelincik²,

Bozkurt³

et al. 2012

J Kartal TR

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“…Failure to undergo apoptosis may enable survival of transformed cells that are prone to undergo further genetic alteration and show genomic instability, leading to the invasive phenotype. 13,14 Either downregulation of proapoptotic or upregulation of antiapoptotic activity may promote tumour survival.…”

Section: Introductionmentioning

confidence: 99%

Germline BCL-2 sequence variants and inherited predisposition to prostate cancer

Kidd

Coulibaly

Templeton

et al. 2006

Prostate Cancer Prostatic Dis

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Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant À938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.

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Expression of Bcl-2, Bax, and p53 in high-grade prostatic intraepithelial neoplasia and localized prostate cancer: relationship with apoptosis and proliferation

Cited by 77 publications

References 41 publications

Bcl‐2 proto‐oncogene expression in low‐ and high‐grade prostatic intraepithelial neoplasia

Bcl‐2 proto‐oncogene expression in low‐ and high‐grade prostatic intraepithelial neoplasia

Significance of Ki-67, BCL-2 and C-erbB2 markers in benign, premalign and malign prostatic lesions

Germline BCL-2 sequence variants and inherited predisposition to prostate cancer

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