Expression of AIF and Caspase-3 in New Zealand rabbit with Cervical Spondylosis Myelopathy model

Ibrahim, Sabri; Mousa, Abdurrahman; Riawan, Wibi

doi:10.1016/j.amsu.2021.102604

Cited by 7 publications

(3 citation statements)

References 21 publications

(31 reference statements)

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“…We modeled a mild myelopathy in hope that conservative therapy without decompression could be performed. For the method of making animal models in this study, the authors have conducted two previous preliminary studies, the results are in accordance with myelopathy [20], [21].…”

Section: Introductionsupporting

confidence: 62%

Olive Polyphenol as Neuroprotective in Chronic Cervical Myelopathy Rabbit Model

Ibrahim

Nasution

Danil

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Olive polyphenols are known to be an anti-oxidants and anti-inflammatory agents. AIM: The purpose of this study was to determine the potential neuroprotective effect on chronic cervical myelopathy rabbit model. METHODS: This study was divided into six groups; control negative (Sham-Operated) group, control positive 1 and 2, treatment groups 1, 2, and 3. Olive leaf extract (OLE) gives 350 mg/kg BW and spinal cord sample was taken at the compression level C5. Histopathological assessment and immunohistochemistry of neurofilaments (NF), S-100, brain derived neurotrophic factor (BDNF), and evaluation of functional motoric outcome were done before animals were terminated. RESULTS: Chronic cervical myelopathy in rabbit model causes decreased expression of NF, S-100, BDNF, and decreased motor function. Oral administration of OLE increased the expression of these biomarkers and improved motor function outcomes. DISCUSSION: These findings indicate that OLE may be effective in protecting chronic cervical myelopathy in rabbit model.

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Section: Introductionsupporting

confidence: 62%

Olive Polyphenol as Neuroprotective in Chronic Cervical Myelopathy Rabbit Model

Ibrahim

Nasution

Danil

et al. 2022

Open Access Maced J Med Sci

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“…We modeled a mild myelopathy so that conservative therapy without decompression could be performed. For the method of making animal models in this study, the authors have conducted two previous preliminary studies, the results are in accordance with myelopathy [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 59%

Potential benefit of olive leaf extract in cervical spondylotic myelopathy model

Ibrahim

Nasution

Danil

et al. 2022

Annals of Medicine &Amp; Surgery

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Introduction Cervical spondylosis is the most common cause of myelopathy in the cervical due to chronic compression of the spinal cord in patients aged 55 years or older. Recent studies suggest that olive extracts suppress inflammation and reduce stress oxidative injury. The purpose of this study was to determine the potential neuroprotective effects of olive leaf extract (OLE) in an experimental cervical spondylotic myelopathy model. Methods This study was divided into 6 groups; Control Negative (Sham-Operated) Group, Control Positive 1 & 2 (early chronic and chronic), Treatment Groups 1, 2 & 3 (prophylactic, concomitant & late). Olive leaf extract (OLE) give 350 mg/kg BW and spinal cord sample was taken at the compression level C5. Histopathological assessment and immunohistochemistry of Amyloid-β, p-Tau, TDP-43 dan CD-68 dan evaluation of functional motoric outcome was done before animals were terminated. Results Chronic spinal cord compression increased the expression of Amyloid-β, p-Tau, TDP-43 dan CD-68. OLE 350 mg/kg BW decreased the expression of these biomarkers and increased functional motoric outcome, especially as prophylactic dan concomitant treatment. Discussion These findings indicate that OLE may be effective in protecting cervical spondylotic myelopathy.

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“…Currently, experimental animals for basic research related to the human spine are mainly used for relevant studies by rats, rabbits, dogs, pigs, cattle, sheep, and deer [11][12][13][14] . However, they have signi cant differences in developmental morphology and motor function compared to humans, limiting their application as biomechanical models and the possibility of vertebral body replacement.…”

Section: Introductionmentioning

confidence: 99%

Finite element modeling and comparative mechanical analysis of cervical facet joints in humans and macaques

Zhao,

Lv,

Shi

et al. 2023

Preprint

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Purpose To establish a finite element model of the adult cervical spine and the adult macaque cervical spine and to compare the stress and displacement changes between the two under six working conditions through finite element analysis around the stress characteristics of the facet joint, to provide a theoretical basis for clinical vertebral body replacement. Methods One 40-year-old adult volunteer and one 7-year-old adult male macaque were selected and subjected to spiral CT thin-layer scans, respectively. Moreover, the original cervical spine CT data were imported into Mimics 21.0 to establish a three-dimensional model. The models of cervical spine segments, discs, and ligaments were optimized, assigned, and assembled to organize the mesh. Finally, using Abaqus, the cervical spine finite element model was loaded with 75 N additional load and 1 N-m external dip moment. To discover the mechanical trends and differences by conducting the automated comparison analysis under six working conditions of anterior flexion, posterior extension, left and right lateral flexion, and left and proper rotation. Results Both human and macaque cervical vertebrae have cervical facet joints. Furthermore, finite element modeling comparison revealed that the uncovertebral joints' stress and displacement changes were generally consistent between the two. The stress and displacement concentrations were all at C6. There was a significant difference between the human and the macaque. Conclusions Macaques can be the best alternative animal model for clinical studies of the cervical spine, providing a theoretical basis for clinical cervical vertebral body replacement and other aspects.

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Expression of AIF and Caspase-3 in New Zealand rabbit with Cervical Spondylosis Myelopathy model

Cited by 7 publications

References 21 publications

Olive Polyphenol as Neuroprotective in Chronic Cervical Myelopathy Rabbit Model

Olive Polyphenol as Neuroprotective in Chronic Cervical Myelopathy Rabbit Model

Potential benefit of olive leaf extract in cervical spondylotic myelopathy model

Finite element modeling and comparative mechanical analysis of cervical facet joints in humans and macaques

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