Potential benefit of olive leaf extract in cervical spondylotic myelopathy model

Abstract

Introduction Cervical spondylosis is the most common cause of myelopathy in the cervical due to chronic compression of the spinal cord in patients aged 55 years or older. Recent studies suggest that olive extracts suppress inflammation and reduce stress oxidative injury. The purpose of this study was to determine the potential neuroprotective effects of olive leaf extract (OLE) in an experimental cervical spondylotic myelopathy model. Methods This study was divided into 6 groups; Control Negative (Sham-Operated) Group, Control Positive 1 & 2 (early chronic and chronic), Treatment Groups 1, 2 & 3 (prophylactic, concomitant & late). Olive leaf extract (OLE) give 350 mg/kg BW and spinal cord sample was taken at the compression level C5. Histopathological assessment and immunohistochemistry of Amyloid-β, p-Tau, TDP-43 dan CD-68 dan evaluation of functional motoric outcome was done before animals were terminated. Results Chronic spinal cord compression increased the expression of Amyloid-β, p-Tau, TDP-43 dan CD-68. OLE 350 mg/kg BW decreased the expression of these biomarkers and increased functional motoric outcome, especially as prophylactic dan concomitant treatment. Discussion These findings indicate that OLE may be effective in protecting cervical spondylotic myelopathy.

Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer’s Disease

“…The effect of an olive leaf extract containing 40% OLE on Aβ production was also investigated in male white rabbits, although not in an AD model but in one of cervical myopathy. The increase in Aβ in spinal cord tissue neuron cells after receiving compression treatment was effectively reduced by the treatment [45]. These results could be attributed to the high content of OLE aglycone present in olive leaves, which was also demonstrated to reduce Aβ-induced neurotoxicity through the reduction in Aβ aggregates in rats cerebrally injected with Aβ 42 [46].…”

“…Those transcription factors were also involved in the protective effect of the treatment against the Aβ proteotoxicity [35]. Likewise, in a rabbit model, extracts with the same percentage of OLE decreased the high levels of p-Tau in spinal cord tissue neuron cells after receiving compression treatment in the cervical myelopathy [45]. These results might be attributed to the high content of OLE, OLE aglycone, and HT, which have been shown to prevent Tau fibrillization in vitro [48].…”

Encapsulation of Olive (Olea europaea L.) Pruning Waste Particles by Supercritical CO2 Technology

“…In European and Mediterranean countries, olive leaf extract is used in natural remedies. Iranians use olive leaves to treat wounds and skin diseases [ 2 ]. More than 200 chemical compounds are found in the olive plant, including stearols, carotenes, triterpene alcohols and phenolic compounds.…”

“…Among the most abundant triterpenes are oleanolic acid, erythrodiol, maslinic acid and uvaol [ 3 ]. There are at least 30 phenolic compounds found in olives, including oleuropein and elecanthal [ 2 ].…”

Effect of Using Ethanol Extract of Artocarpus Heterophyllus Leaves and Olea Europea Fruit Oil Combination on Facial Skin

“…Currently, herbal skin treatments that used natural ingredients are popular and are claimed to have intrinsic efficacy by their routine daily use ( 2 ). Artocarpus heterophyllus ( A. heterophyllus ) and Olea europea (OE) or olive oil are natural ingredients frequently used for skin care due to their bioactivities benefitting skin health ( 3 ).…”