Expression of ADAMTS2 and ADAMTS5 in the salivary gland of rats after radioiodine therapy

Sadic, Murat; Demirel, Koray; Halaçlı, Sevil Oskay; Karakök, Emre; Koca, Gökhan; Ekinci, Özgür; Demircan, Kadir; Korkmaz, Meliha

doi:10.1097/mnm.0000000000000781

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…However, besides that it has therapeutically effect on thyroid tissue I-131 can cause some undesirable effects on other organs of the body. One of the undesirable damages of radiation in biological systems is the genotoxic effects on DNA, and the other is the formation of reactive oxygen species (ROS) by interacting with water molecules that are abundant in the cell [3][4][5]. These effects have been revealed up to now, and that radioactive I-131 caused an increase in ROS formation in the body and the DNA damage, have been reported by various researchers [6,7].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the effect of vitamin C on the oxidative stress parameters induced by i-131 treatment applied in patients with hyperthyroidism

Özdemir¹,

Tan²,

Çakır³

et al. 2018

Nucl Med Biomed Imaging

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Aim or purpose:The radioactive I-131 (RAI) treatment is an adjuvant treatment option that increasingly is applied in hyperthyroidism, toxic nodular goitre and Grave's disease. The aim of this study is to investigate the possible radioprotective role of Vitamin C in I-131(RAI) treatment in hyperthyroid patients. Material and methods:The patients who were undergone RAI treatment due to hyperthyroidism divided into 2 groups. While vitamin C was not given to the 1st group (24 patients) during RAI treatment, vitamin C in oral dose 1000 mg / day was given to the 2nd group (28 patients) throughout 1 week starting from 1 day before their treatments. Peripheral blood was drawn twice from the both groups before RAI treatment and on the 7th day after treatment. The oxidative stress parameters which are total antioxidant status (TAS), total oxidant status (TOS), ischemia modified albumin (IMA), malondialdehyde (MDA) were measured by obtaining serum samples, and their blood levels were measured biochemically with ELISA method by applying the 8-hydroxydeoxyguanosine (8-OHdG) kit protocols for DNA damage. The radioprotective effect of the Vit C was investigated as statistically by comparing the oxidative stress parameters that were obtained from both groups. Results and conclusion:According to the results of our study, it was seen that vitamin C reduces the effects of oxidative stress that is caused by radiation, and it was thought that vitamin C supplementation is beneficial for patients to whom therapeutic radioactive materials was undergone.

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Section: Introductionmentioning

confidence: 99%

Investigation of the effect of vitamin C on the oxidative stress parameters induced by i-131 treatment applied in patients with hyperthyroidism

Özdemir¹,

Tan²,

Çakır³

et al. 2018

Nucl Med Biomed Imaging

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Sialadenitis as a complication of radioiodine therapy in patients with thyroid cancer: where do we stand?

et al. 2021

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Experimental Animal Model Systems for Understanding Salivary Secretory Disorders

Kim

Jung

2020

IJMS

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Salivary secretory disorders are life-disrupting pathologic conditions with a high prevalence, especially in the geriatric population. Both patients and clinicians frequently feel helpless and get frustrated by the currently available therapeutic strategies, which consist mainly of palliative managements. Accordingly, to unravel the underlying mechanisms and to develop effective and curative strategies, several animal models have been developed and introduced. Experimental findings from these models have contributed to answer biological and biomedical questions. This review aims to provide various methodological considerations used for the examination of pathological fundamentals in salivary disorders using animal models and to summarize the obtained findings. The information provided in this review could provide plausible solutions for overcoming salivary disorders and also suggest purpose-specific experimental animal systems.

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Expression of ADAMTS2 and ADAMTS5 in the salivary gland of rats after radioiodine therapy

Abstract: An increase in the mRNA expression levels of ADAMTS2 and ADAMTS5 genes was detected in the RAI-administered groups. These results suggested that ADAMTS2 and ADAMTS5 genes might play a role in radiation exposure and radioiodine-induced SG changes.

Cited by 3 publications

References 18 publications

Investigation of the effect of vitamin C on the oxidative stress parameters induced by i-131 treatment applied in patients with hyperthyroidism

Investigation of the effect of vitamin C on the oxidative stress parameters induced by i-131 treatment applied in patients with hyperthyroidism

Sialadenitis as a complication of radioiodine therapy in patients with thyroid cancer: where do we stand?

Experimental Animal Model Systems for Understanding Salivary Secretory Disorders

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