Investigation of the effect of vitamin C on the oxidative stress parameters induced by i-131 treatment applied in patients with hyperthyroidism

Abstract

Aim or purpose:The radioactive I-131 (RAI) treatment is an adjuvant treatment option that increasingly is applied in hyperthyroidism, toxic nodular goitre and Grave's disease. The aim of this study is to investigate the possible radioprotective role of Vitamin C in I-131(RAI) treatment in hyperthyroid patients. Material and methods:The patients who were undergone RAI treatment due to hyperthyroidism divided into 2 groups. While vitamin C was not given to the 1st group (24 patients) during RAI treatment, vitamin C in oral dose 1000 mg / day was given to the 2nd group (28 patients) throughout 1 week starting from 1 day before their treatments. Peripheral blood was drawn twice from the both groups before RAI treatment and on the 7th day after treatment. The oxidative stress parameters which are total antioxidant status (TAS), total oxidant status (TOS), ischemia modified albumin (IMA), malondialdehyde (MDA) were measured by obtaining serum samples, and their blood levels were measured biochemically with ELISA method by applying the 8-hydroxydeoxyguanosine (8-OHdG) kit protocols for DNA damage. The radioprotective effect of the Vit C was investigated as statistically by comparing the oxidative stress parameters that were obtained from both groups. Results and conclusion:According to the results of our study, it was seen that vitamin C reduces the effects of oxidative stress that is caused by radiation, and it was thought that vitamin C supplementation is beneficial for patients to whom therapeutic radioactive materials was undergone.