2011
DOI: 10.1111/j.1472-765x.2011.03027.x
|View full text |Cite
|
Sign up to set email alerts
|

Expression of acrB and ramA in fluoroquinolone resistant mutants from multi-drug resistant Salmonella enterica serovar Haardt

Abstract: Aims:  To identify the effect of elevation of resistance in multi‐drug resistant Salmonella enterica serovar Haardt with reduced susceptibility to ciprofloxacin, a parental strain SAL59‐FC‐KF04 was exposed to fluoroquinolone. Sequence of quinolone resistance determining region (QRDR) was analysed and expression level of efflux pump related genes was compared between the parental strain and the derived mutants. Methods and Results:  The molecular expression levels of efflux pump genes (acrB, acrF) and transcrip… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2012
2012
2021
2021

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(1 citation statement)
references
References 39 publications
0
1
0
Order By: Relevance
“…Salmonella express chromosomally and plasmid-encoded proteins that protect them against quinolones. In terms of chromosomally encoded proteins, mutations can alter the drug targets [ 35 , 36 , 37 ] or affect local and global repressors that result in down-regulated expression of outer membrane porins [ 38 , 39 ] or up-regulated expression of inner membrane efflux transporters [ 40 , 41 , 42 , 43 ]. These defense mechanisms can be further enhanced by transferable resistance elements residing on plasmids.…”
Section: Known Mechanisms Of Quinolone Resistancementioning
confidence: 99%
“…Salmonella express chromosomally and plasmid-encoded proteins that protect them against quinolones. In terms of chromosomally encoded proteins, mutations can alter the drug targets [ 35 , 36 , 37 ] or affect local and global repressors that result in down-regulated expression of outer membrane porins [ 38 , 39 ] or up-regulated expression of inner membrane efflux transporters [ 40 , 41 , 42 , 43 ]. These defense mechanisms can be further enhanced by transferable resistance elements residing on plasmids.…”
Section: Known Mechanisms Of Quinolone Resistancementioning
confidence: 99%