Expression of ABH/Lewis-related antigens as prognostic factors in patients with breast cancer

Nakagoe, Tohru; Fukushima, Kiyoyasu; Itoyanagi, Noriaki; Ikuta, Yasushi; Oka, Teruaki; Nagayasu, Takeshi; Ayabe, Hiroyoshi; Hara, Shinsuke; Ishikawa, Hiroichi; Matsuda, Hiroyuki

doi:10.1007/s00432-002-0334-5

Cited by 42 publications

(10 citation statements)

References 38 publications

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“…Furthermore, the adhesion of tumor cells via sLe a and sLe x to vascular endothelial cells may facilitate hematogenous metastasis [33]. Although several studies have demonstrated a prognostic value for the AB0 blood group antigens in various malignancies, the results of these studies are inconsistent suggesting that the biological role of ABH antigens may be disease-specific [37-40]. Experimental data on murine colon cancer cells suggest the expression of blood group antigens A and B to mediate the resistance to apoptosis which may facilitate the escape from immune surveillance [41].…”

Section: Discussionmentioning

confidence: 99%

AB0 blood group and prognosis in patients with pancreatic cancer

et al. 2012

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Background Although blood group 0 is associated with a reduced risk of pancreatic cancer, little is known about the role of AB0 blood group antigens in disease progression. We assessed the prognostic relevance of AB0 blood status in a large cohort of patients with resected pancreatic cancer. Methods A total of 627 patients, who underwent resection for pancreatic ductal adenocarcinoma between October 2001 and December 2008 were enrolled. The relationship between AB0 blood group status and outcome was analyzed using univariate and multivariate Cox regression analyses. Results In patients with pancreatic cancer the incidence of blood group 0 (31%) was lower compared to 13.044 patients without pancreatic cancer (38%) (p = 0.0005). There were no significant differences in clinicopathologic characteristics among patients with different AB0 blood groups. The 3-year and 5-year overall survival rates were 29% and 14%. On univariate analysis AB0 blood group status did not correlate with survival (p = 0.39). Multivariate analysis, however, revealed a favorable and independent impact of blood group 0 on survival (Hazard ratio 0.78; 95% confidence interval 0.62 – 0.99; p = 0.037). Conclusion AB0 blood group status is associated independently with the prognosis of patients with resected pancreatic cancer.

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Section: Discussionmentioning

confidence: 99%

AB0 blood group and prognosis in patients with pancreatic cancer

et al. 2012

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“…The expression of sialyl-Lewis antigens is weak in carcinoma in situ , is moderate in invasive carcinomas without metastases and is high in primary carcinoma with lymph node metastases, showing a good correlation with the metastatic risk in breast cancer patients [70]. Immunohistochemistry of breast cancer tissue suggests that sLe x expression is an independent prognostic indicator of survival regardless of the size of the primary tumour and lymph node involvement [71]. …”

Section: Lewis Antigens In Breast Cancermentioning

confidence: 99%

Tumour-associated carbohydrate antigens in breast cancer

et al. 2010

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Glycosylation changes that occur in cancer often lead to the expression of tumour-associated carbohydrate antigens. In breast cancer, these antigens are usually associated with a poor prognosis and a reduced overall survival. Cellular models have shown the implication of these antigens in cell adhesion, migration, proliferation and tumour growth. The present review summarizes our current knowledge of glycosylation changes (structures, biosynthesis and occurrence) in breast cancer cell lines and primary tumours, and the consequences on disease progression and aggressiveness. The therapeutic strategies attempted to target tumour-associated carbohydrate antigens in breast cancer are also discussed.

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“…When found at the surface of carcinoma cells, they are usually associated with a poor prognosis in tumors of certain type, stage and grade, and reduced overall survival [98,139]. The expression of sLe x in breast cancers is also considered to be an independent prognostic indicator of survival regardless of the primary tumor and lymph node involvement [141]. Elevated sLe x expression was found in patients with metastases compared to those without [136], and sLe x was increased in serum of patients with advanced breast cancer [135,136].…”

Section: Tac In Gynecological Cancersmentioning

confidence: 99%

Tumor-Associated Glycans and Their Role in Gynecological Cancers: Accelerating Translational Research by Novel High-Throughput Approaches

et al. 2012

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Glycans are important partners in many biological processes, including carcinogenesis. The rapidly developing field of functional glycomics becomes one of the frontiers of biology and biomedicine. Aberrant glycosylation of proteins and lipids occurs commonly during malignant transformation and leads to the expression of specific tumor-associated glycans. The appearance of aberrant glycans on carcinoma cells is typically associated with grade, invasion, metastasis and overall poor prognosis. Cancer-associated carbohydrates are mostly located on the surface of cancer cells and are therefore potential diagnostic biomarkers. Currently, there is increasing interest in cancer-associated aberrant glycosylation, with growing numbers of characteristic cancer targets being detected every day. Breast and ovarian cancer are the most common and lethal malignancies in women, respectively, and potential glycan biomarkers hold promise for early detection and targeted therapies. However, the acceleration of research and comprehensive multi-target investigation of cancer-specific glycans could only be successfully achieved with the help of a combination of novel high-throughput glycomic approaches.

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Expression of ABH/Lewis-related antigens as prognostic factors in patients with breast cancer

Abstract: Thus, expression of sialyl Le(x) antigen in tumor cells is associated with poor prognosis in patients with breast cancer and must be considered in the design of future therapeutic trials.

Cited by 42 publications

References 38 publications

AB0 blood group and prognosis in patients with pancreatic cancer

AB0 blood group and prognosis in patients with pancreatic cancer

Tumour-associated carbohydrate antigens in breast cancer

Tumor-Associated Glycans and Their Role in Gynecological Cancers: Accelerating Translational Research by Novel High-Throughput Approaches

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