AB0 blood group and prognosis in patients with pancreatic cancer

Abstract

Background Although blood group 0 is associated with a reduced risk of pancreatic cancer, little is known about the role of AB0 blood group antigens in disease progression. We assessed the prognostic relevance of AB0 blood status in a large cohort of patients with resected pancreatic cancer. Methods A total of 627 patients, who underwent resection for pancreatic ductal adenocarcinoma between October 2001 and December 2008 were enrolled. The relationship between AB0 blood group status and outcome was analyzed using univariate and multivariate Cox regression analyses. Results In patients with pancreatic cancer the incidence of blood group 0 (31%) was lower compared to 13.044 patients without pancreatic cancer (38%) (p = 0.0005). There were no significant differences in clinicopathologic characteristics among patients with different AB0 blood groups. The 3-year and 5-year overall survival rates were 29% and 14%. On univariate analysis AB0 blood group status did not correlate with survival (p = 0.39). Multivariate analysis, however, revealed a favorable and independent impact of blood group 0 on survival (Hazard ratio 0.78; 95% confidence interval 0.62 – 0.99; p = 0.037). Conclusion AB0 blood group status is associated independently with the prognosis of patients with resected pancreatic cancer.

ABO Blood Group IgM Isoagglutinins Interact with Tumor-Associated O-Glycan Structures in Pancreatic Cancer

“…Blood group AB did not show a change in frequency, but this is probably due to the small sample size of patients with PDAC. In general, our findings are in accordance to previous studies, which as well showed a lower frequency of PDAC in blood group O (3,27,28).…”

“…These findings are also in consistence with a previous study, which failed to show significant differences in clinicopathologic characteristics among patients with different ABO blood groups (28). In contrast, tumor grading (G) showed significant differences within Figure 3.…”

“…A study with mainly Caucasian population revealed a favorable and independent impact of blood group O on survival using multivariate analysis (3). However, univariate analysis of ABO blood group status did not correlate with survival (3,28).…”

ABO blood groups and pancreatic cancer risk and survival: Results from the PANcreatic Disease ReseArch (PANDoRA) consortium

“…To date, this has been examined only in studies with a smaller sample size than ours (16,17) with inconsistent results. The samples from Germany partially overlap with those used in a recent study (28). Due to the lack of information on CA19-9, lymph node status and grading, we were not able to replicate the statistically significant (0.037) association they found using a multivariate analysis.…”

Effect of ABO Blood Group on Survival of Resected Lung Cancer Patients: A Retrospective Study

“…including colon cancer, pancreatic cancer, nasopharyngeal carcinoma, esophageal cancer, breast cancer, skin cancer, renal cell carcinoma and gastric cancer [7][8][9][10][11][12][13][14]. Although the study by Lee et al established the survival of NSCLC patients who received curative surgery within the context of ABO blood group, the aim of their study was to investigate the prognostic role of expression of blood group antigen A in tumor cells [15].…”