“…MiRNAs are involved in tumor proliferation, apoptosis, differentiation, invasion, and metastasis, as well as tumorigenesis [ 3 , 4 ]. MiRNAs dysregulation is a general feature in many cancers [ 5 ], such as glioma [ 6 ] and papillary thyroid carcinoma [ 7 ],; miR-30a expression is overexpressed but downregulated in lung cancer [ 8 , 9 ], giant cell tumor [ 10 ], breast cancer[ 11 – 15 ], renal cell carcinoma[ 16 ], hepatocellular carcinoma[ 17 , 18 ], colorectal cancer[ 19 , 20 ], ovary cancer[ 21 ], chondrosarcoma[ 22 ], gastric cancer[ 23 , 24 ], urothelial carcinoma of the bladder[ 25 ], nasopharyngeal carcinoma[ 26 ], Ewing tumor[ 27 ], pancreatic cancer[ 28 ], prostate cancer[ 29 ], and cervical cancer[ 30 ]. This data implies that the miR-30 family may play different roles as oncogenes or tumor suppressor genes depending on the type of cancer; similarly, miR-30a also plays an important role in cancer development and progression by modulating target genes, including inhibiting proliferation, invasion, and migration, inducing apoptosis.…”