Expression, Distribution, and Role of C-Type Lectin Receptors in the Human and Animal Middle Ear and Eustachian Tube: A Review

Jung, Su Young; Kim, Sung Su; Kim, Young Il; Chung, Hee Yong; Kim, Sang Hoon

doi:10.3390/molecules23040734

Cited by 3 publications

(2 citation statements)

References 85 publications

(107 reference statements)

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“…CLECs are calcium-dependent carbohydrate binding proteins that are secreted to the extracellular matrix and can coordinate cellextracellular matrix signaling 57,58 . CLEC domain containing proteins have diverse functions including immune response, apoptosis and cell adhesion 57 .…”

Section: C-type Lectins Are Essential For C Elegans Germline Functionmentioning

confidence: 99%

The matrisome landscape controlling in vivo germ cell fates

Amran,

Pigatto,

Farley

et al. 2024

Nat Commun

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The developmental fate of cells is regulated by intrinsic factors and the extracellular environment. The extracellular matrix (matrisome) delivers chemical and mechanical cues that can modify cellular development. However, comprehensive understanding of how matrisome factors control cells in vivo is lacking. Here we show that specific matrisome factors act individually and collectively to control germ cell development. Surveying development of undifferentiated germline stem cells through to mature oocytes in the Caenorhabditis elegans germ line enabled holistic functional analysis of 443 conserved matrisome-coding genes. Using high-content imaging, 3D reconstruction, and cell behavior analysis, we identify 321 matrisome genes that impact germ cell development, the majority of which (>80%) are undescribed. Our analysis identifies key matrisome networks acting autonomously and non-autonomously to coordinate germ cell behavior. Further, our results demonstrate that germ cell development requires continual remodeling of the matrisome landscape. Together, this study provides a comprehensive platform for deciphering how extracellular signaling controls cellular development and anticipate this will establish new opportunities for manipulating cell fates.

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Section: C-type Lectins Are Essential For C Elegans Germline Functionmentioning

confidence: 99%

The matrisome landscape controlling in vivo germ cell fates

Amran,

Pigatto,

Farley

et al. 2024

Nat Commun

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“…According to molecular structure, they can be classified into soluble and transmembrane CLRs. They not only recognize and take up various antigens, but also transmit signals in cells, helping macrophages and dendritic cells to effectively induce innate immunity (Lepenies et al, 2013 ; Jung et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Rabbit Nucleotide-Binding Oligomerization Domain-2 (NOD2)-Mediated Signaling Pathway in Resistance to Enterohemorrhagic Escherichia coli Infection

Guo

Xiao

et al. 2018

Front. Cell. Infect. Microbiol.

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Nucleotide-binding oligomerization domain 2 (NOD2), a member of the NOD-like receptors (NLRs) family that is well-known to play a key role in innate immune responses and is involved in innate antibacterial responses. In this study, rabbit NOD2 (rNOD2) was cloned from rabbit kidney (RK) cells. It was distributed in various tissues, and the highest level of rNod2 was detected in spleen. Moreover, the expression of rNod2 was significantly upregulated in the heart, liver, and spleen induced by enterohemorrhagic Escherichia coli (EHEC). Overexpression of rNOD2 induced the expression of pro-inflammatory cytokine, including Il1β, Il6, Ifn-γ, and Tnf, as well as defensins, including Defb124, Defb125, and Defb128 through the nuclear factor (NF)-κB signaling pathway. Furthermore, overexpression of rNOD2 inhibited the growth of EHEC, and knockdown of rNOD2 or inhibition of the NF-κB pathway promoted its replication. In addition, our results suggest that rNOD2 can significantly activate NF-κB signaling and trigger antibacterial defenses to increase the expression of pro-inflammatory cytokine and defensins after stimulation by EHEC. These findings are useful to further understanding the innate immune system of rabbits and providing a new perspective for the prevention of bacterial diseases in rabbits.

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