The matrisome landscape controlling in vivo germ cell fates
Aqilah Amran,
Lara Pigatto,
Johanna Farley
et al.
Abstract:The developmental fate of cells is regulated by intrinsic factors and the extracellular environment. The extracellular matrix (matrisome) delivers chemical and mechanical cues that can modify cellular development. However, comprehensive understanding of how matrisome factors control cells in vivo is lacking. Here we show that specific matrisome factors act individually and collectively to control germ cell development. Surveying development of undifferentiated germline stem cells through to mature oocytes in t… Show more
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