Expression changes caused by the peptide semax in the intracellular signal pathway genes in rat hippocamp

Agapova, T. Yu.; Agniullin, Ya. V.; Silachev, D. N.; Шадрина, М. И.; Slominsky, Petr; Shram, S. I.; Limborskaya, S. A.; Myasoedov, N. F.

doi:10.1134/s1607672907060129

Cited by 4 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These microarrays make it possible to test the expression of dozens of genes simultaneously using RT‐PCR. In the study by Agapova et al using Signal Transduction Pathway Finger gene panels (SABiosciences) containing 84 genes belonging to 18 different signaling pathways were used to analyze their expression in the rat hippocampus under the influence of Semax 27 . Many genes (27/84) significantly changed their activity levels.…”

Section: Analysis Of Gene Expression Under the Action Of Peptides: Frmentioning

confidence: 99%

“…Changes in gene expression in two signaling pathways (Wnt and nuclear factor kappa B [NF‐κB]) turned out to be the largest. Proteins related to these signaling pathways are involved in cell differentiation, survival, and other important processes 27 . Thus, in studies at this level of technology, it became clear that peptides (e.g., Semax) can affect the activity of a significant number of genes, including those involved in cell regulatory systems.…”

Section: Analysis Of Gene Expression Under the Action Of Peptides: Frmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacotranscriptomics of peptide drugs with neuroprotective properties

Dergunova

Filippenkov

Limborska

et al. 2020

Medicinal Research Reviews

View full text Add to dashboard Cite

Here we present a review of studies on the effects of peptides with neuroprotective properties on gene transcription in nerve cells. The few published works in this area clearly demonstrate massive changes in cell transcriptomes induced by peptides under normal conditions and under conditions of experimental brain ischemia. These changes significantly affect signaling and metabolic pathways, affecting various body systems and confirming the multiple target actions of peptides. The importance of noncoding RNAs in the regulation of these processes is shown, and we discuss the prospects of research for determining the main mechanisms of peptide regulation, which is necessary for the further development of drugs with targeted neuroprotective effects.

show abstract

Section: Analysis Of Gene Expression Under the Action Of Peptides: Frmentioning

confidence: 99%

Section: Analysis Of Gene Expression Under the Action Of Peptides: Frmentioning

confidence: 99%

Pharmacotranscriptomics of peptide drugs with neuroprotective properties

Dergunova

Filippenkov

Limborska

et al. 2020

Medicinal Research Reviews

View full text Add to dashboard Cite

show abstract

“…Agapova et al studied the effect of Semax on the expression of genes involved in intracellular signaling pathways in the hippocampus of healthy animals using the "RT²Profiler™ PCR Array Signal Transduction Pathway Finder" panel (SABioscience, USA), which includes 84 genes. Those authors found that the intranasal administration of a single dose of the peptide (50 μg/kg) led to a change in the mRNA levels of several genes involved in the implementation of the Wnt (Ccnd1, Cdh1, Pparg, and Vegf) and NF-kB (Birc2, Tnfb, If1, Nos2a/iNos, and Tnfα) pathways, which are involved in the regulation of processes associated with the survival of neurons and neuronal cell cultures [97].…”

Section: Effect Of Semax On Gene Transcriptionmentioning

confidence: 99%

A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides

Kolomin¹,

Шадрина²,

Slominsky³

et al. 2013

View full text Add to dashboard Cite

Natural regulatory peptides are biologically active compounds that are produced by various cells and provide a link among the main regulatory systems of the body. The field of research into the biologic activity of endogenous regulatory peptides is extremely vast. These peptides affect the cardiovascular, immune, reproductive, endocrine, digestive, and other systems, alter energy metabolism, and are especially effective in the regulation of the central nervous system. Despite of the wide range of preventive and therapeutic effects of natural regulatory peptides and proteins, their application in clinical practice is difficult. This is primarily because of their extreme instability, as they are rapidly degraded by proteases of the gastrointestinal tract, blood, cerebrospinal fluid, and other biologic media. Compounds with higher stability (i.e., a considerably longer half-life compared with that of natural molecules) and the ability to provide a directional effect on the various body systems were obtained from modifications of endogenous regulatory peptides. Synthetic analogs of regulatory peptides, as a rule, contain only natural amino acids in their composition, and their biodegradation does not lead to the formation of toxic products; thus, they have fewer side effects. This review focuses on the consideration of two synthetic regulatory peptides, Semax and Selank, which were the bases for the creation of new drugs that are used effectively in the treatment of various diseases of the nervous system. The synthetic analog of an adrenocorticotropic hormone 4-10 fragment (ACTH 4-10) Semax is a powerful neuroprotective agent that is particularly effective as a therapy for stroke. Selank was synthesized on the basis of the natural immunomodulator tuftsin. Selank is a powerful anxiolytic that is used as a therapy for generalized anxiety disorder and neurasthenia without sedative and muscle-relaxant effects. This review presents the results of research aimed at studying the influence of these peptides on the transcriptome of brain cells. The problems of drugs developed based on the clinical activities of Semax and Selank are discussed separately.

show abstract

Semax as a Universal Drug for Therapy and Research

Koroleva

Myasoedov

2018

Biol Bull Russ Acad Sci

View full text Add to dashboard Cite

Expression changes caused by the peptide semax in the intracellular signal pathway genes in rat hippocamp

Cited by 4 publications

References 8 publications

Pharmacotranscriptomics of peptide drugs with neuroprotective properties

Pharmacotranscriptomics of peptide drugs with neuroprotective properties

A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides

Semax as a Universal Drug for Therapy and Research

Contact Info

Product

Resources

About