Pharmacotranscriptomics of peptide drugs with neuroprotective properties

Abstract

Here we present a review of studies on the effects of peptides with neuroprotective properties on gene transcription in nerve cells. The few published works in this area clearly demonstrate massive changes in cell transcriptomes induced by peptides under normal conditions and under conditions of experimental brain ischemia. These changes significantly affect signaling and metabolic pathways, affecting various body systems and confirming the multiple target actions of peptides. The importance of noncoding RNAs in the regulation of these processes is shown, and we discuss the prospects of research for determining the main mechanisms of peptide regulation, which is necessary for the further development of drugs with targeted neuroprotective effects.

Insight into Glyproline Peptides’ Activity through the Modulation of the Inflammatory and Neurosignaling Genetic Response Following Cerebral Ischemia–Reperfusion

“…The manifestation of ACTH(4-7)’s action may be associated with the so-called synactonic mechanism. Synactone can be defined as a combination of the peptide itself and the products of its metabolism, acting in a certain sequence and by interaction [ 61 , 62 , 63 , 64 ]. Both the main parent peptide and secondary peptides of its metabolism have their own binding sites and together make up a single complex of bioregulators [ 61 , 62 , 63 , 64 ].…”

“…Synactone can be defined as a combination of the peptide itself and the products of its metabolism, acting in a certain sequence and by interaction [ 61 , 62 , 63 , 64 ]. Both the main parent peptide and secondary peptides of its metabolism have their own binding sites and together make up a single complex of bioregulators [ 61 , 62 , 63 , 64 ]. The secondary metabolites of Semax are known, and their diversity is ensured by the active metabolism of the ACTH(4-7) fragment [ 61 ].…”

Neurodegenerative disorders—Searching for targets and new ways of diseases treatment

“…Dergunova et al reviews of studies on the effects of peptides with neuroprotective properties on gene transcription in nerve cells. 20 We believe that very broad analysis of contemporary strategies and specific approaches for treatment neurodegenerative disease presented in this issue could be helpful and stimulating for further successful research in this area. We thank the authors for their excellent contributions, as well as the support of grant № 075-15-2020-777 (of the RMSHE).…”

“…One more genetically based modern direction in drug development – pharmacotranscriptomics aims to reach more accurate drug dosing based on interindividual transcriptome variations. Dergunova et al reviews of studies on the effects of peptides with neuroprotective properties on gene transcription in nerve cells 20 …”

Antistress Action of Melanocortin Derivatives Associated with Correction of Gene Expression Patterns in the Hippocampus of Male Rats Following Acute Stress

“…The polypeptide sequence of ACTH(6–9) is necessary and sufficient to activate most types of MC receptors [ 23 , 24 , 25 , 26 , 27 ]. At the same time, there are suggestions about the allosteric interaction of Semax and ACTH(6–9)PGP with a large number of different receptors [ 28 , 29 ]. However, the molecular mechanisms underlying its anti-stress effects remain unclear.…”