Biochemical Pharmacology volume 80, issue 12, P2009-2020 2010 DOI: 10.1016/j.bcp.2010.06.044 View full text
Lynn Verstrepen, Kelly Verhelst, Geert van Loo, Isabelle Carpentier, Steven C. Ley, Rudi Beyaert

Abstract: AbstractA20 (also known as TNFAIP3) is a cytoplasmic protein that plays a key role in the negative regulation of inflammation and immunity. Polymorphisms in the A20 gene locus have been identified as risk alleles for multiple human autoimmune diseases, and A20 has also been proposed to function as a tumor suppressor in several human B-cell lymphomas. A20 expression is strongly induced by multiple stimuli, including the proinflammatory cytokines TNF and IL-1, and microbial products that trigger pathogen recogn…

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