Expression and Secretion of Neural Cell Adhesion Molecules by Human Pituitary Adenomas

Jong, Irene de; Aylwin, Simon; Olabiran, Y.; Geddes, J. F.; Monson, John P.; Wood, D. F.; Burrin, JM

doi:10.1177/000456329903600516

Cited by 7 publications

(5 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is known that progression to neoplasia involves the ability to adhere and interact with the surrounding cells and extracellular matrix, and loss or adhesion difficulties may be a determinant of epithelial neoplasia ( 36 ). Studies have demonstrated immunohistochemical expression of NCAM in pituitary adenomas, including GH-secreting tumors ( 5 , 37 – 39 ).…”

Section: Discussionmentioning

confidence: 99%

Expression of E-cadherin, Slug and NCAM and its relationship to tumor invasiveness in patients with acromegaly

Mendes

Haag

Trott

et al. 2018

Braz J Med Biol Res

View full text Add to dashboard Cite

Pituitary adenomas account for 10–15% of primary intracranial tumors. Growth hormone (GH)-secreting adenomas account for 13% of all pituitary adenomas and cause acromegaly. These tumors can be aggressive, invade surrounding structures and are highly recurrent. The objective of this study was to evaluate E-cadherin, Slug and neural cell adhesion molecule (NCAM) expression in GH-secreting pituitary adenomas and its relationship to tumor invasiveness. A cross–sectional study of patients who underwent hypophysectomy due to GH-secreting pituitary adenoma from April 2007 to December 2014 was carried out. The medical records were reviewed to collect clinical data. Immediately after surgery, tumor samples were frozen in liquid nitrogen and stored in a biofreezer at –80°C for assessment of E-cadherin 1 (CDH1), SLUG (SNAI2), and NCAM (NCAM1) by real-time PCR. The samples were fixed in formalin and embedded in paraffin for immunohistochemical analysis of E-cadherin and NCAM. Thirty-five patients with acromegaly were included in the study. Of these, 65.7% had invasive tumors. Immunohistochemically, E-cadherin was expressed in 96.7% of patients, and NCAM in 80% of patients. There was no statistically significant relationship between tumor grade or invasiveness and immunohistochemical expression of these markers. Regarding gene expression, 50% of cases expressed CDH1, none expressed SNAI2, and 53.3% expressed NCAM1. There was no statistically significant relationship between tumor grade or invasiveness and gene expression of CDH1, SNAI2, and NCAM1. The absence of Slug overexpression and of E-cadherin and NCAM suppression suggests that expression of these markers is not associated with tumor invasiveness in GH-secreting pituitary adenomas.

show abstract

Section: Discussionmentioning

confidence: 99%

Expression of E-cadherin, Slug and NCAM and its relationship to tumor invasiveness in patients with acromegaly

Mendes

Haag

Trott

et al. 2018

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…However, it is still unknown if it is generated from sarcoplasm, or cleaved outside by proteases to mediate cell adhesion, or with other unidentified functions. Studies on N-CAM derived from cancer cells have associated secreted and serum N-CAM to disease activity in humans, suggesting a potential use for diagnosis and prognosis (De Jong et al, 1999;Jaques et al, 1993). In fact, N-CAM belongs to the key members of immunoglobulin-like CAM (Ig-CAM) family involved in cell-cell and cell-extracellular matrix adhesion processes in innate immunity.…”

Section: Neural-cell Adhesion Moleculementioning

confidence: 99%

Loss of neuromuscular junction integrity and muscle atrophy in skeletal muscle disuse

Sirago

Pellegrino

Bottinelli

et al. 2023

Ageing Research Reviews

View full text Add to dashboard Cite

“…Regarding adenohypophyseal cells, considered neuroendocrine cells expressing neuroendocrine proteins such as synaptophysin, chromogranin A and CD-56 [ 31 ], the existing data from the literature although limited have demonstrated that CD-56 expression does not differ between normal pituitary gland cells and PA cells [ 32 , 33 ]. Furthermore, CD-56 does not seem to be related to either PAs proliferation or its invasiveness [ 32 , 34 , 35 ]. Indeed, in our study CD-56 expression was not significantly correlated with any imaging characteristic of PA (size, extrasellar or cavernous sinus invasion) nor with recurrence.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Factors for Invasiveness and Recurrence of Pituitary Adenomas: A Series of 94 Patients

et al. 2022

View full text Add to dashboard Cite

(1) Background: The aim of the current study is to evaluate the immunohistochemical expression of Ki-67, CD-56, Cyclin-D1 and E-Cadherin in the tissues samples of pituitary adenomas (PAs) and its association with PAs clinical manifestation tumor size, invasiveness and the risk of recurrence. (2) Materials and Methods: Ninety-four patients who underwent endoscope transsphenoidal excision of PAs were included in our study. The immunohistochemical expression of the Cyclin-D1, CD-56, E-Cadherin and Ki-67 markers was analyzed in paraffin-embedded tissue samples. (3) Results: The expression of Cyclin-D1 and Ki-67 index levels was positively correlated with the size (p < 0.001, r = 0.56 and p < 0.001, r = 0.43, respectively), the recurrence (p < 0.001, r = 0.46 and p = 0.007 r = 0.3, respectively), the extrasellar extension (p < 0.001, r = 0.48 and p < 0.001, r = 0.4, respectively) and the cavernous sinus invasion of (p < 0.001, r = 0.39 and p < 0.001, r = 0.3, respectively). No correlation was found between CD-56 and E-Cadherin expression with the size, the invasiveness and the recurrence of PAs. (4) Conclusion: Cyclin-D1 and Ki-67 are promising immunohistochemical markers in predicting the invasive behavior and recurrence of PAs in contrast to E-Cadherin and CD-56 which did not seem to be associated with PAs behavior post-surgery. However, larger studies are required in order to establish their role in the routine evaluation of PAs.

show abstract

Expression and Secretion of Neural Cell Adhesion Molecules by Human Pituitary Adenomas

Cited by 7 publications

References 4 publications

Expression of E-cadherin, Slug and NCAM and its relationship to tumor invasiveness in patients with acromegaly

Expression of E-cadherin, Slug and NCAM and its relationship to tumor invasiveness in patients with acromegaly

Loss of neuromuscular junction integrity and muscle atrophy in skeletal muscle disuse

Prognostic Factors for Invasiveness and Recurrence of Pituitary Adenomas: A Series of 94 Patients

Contact Info

Product

Resources

About