“…Since their identification in 2000, Panx1 channels have been characterized as ATP release channels that may play a pivotal role in supporting purinergic signaling in a multitude of cell types (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Importantly, Panx1 channels mediate ATP release from vascular smooth muscle and endothelial cells (7,14), circulating erythrocytes (11,15), airway epithelial cells (13), astrocytes (5,16,17) and T-cells (6,8).…”