Expression and prognostic significance of EFNB2 and EphB4 genes in patients with oesophageal squamous cell carcinoma

Tachibana, Mitsuo; Tonomoto, Yasuhito; Hyakudomi, Ryoji; Hyakudomi, Miki; Hattori, Shinji; Ueda, Shuhei; Kinugasa, Shoichi; Yoshimura, Hiroshi

doi:10.1016/j.dld.2007.05.013

Cited by 29 publications

(26 citation statements)

References 29 publications

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“…The miR-200 family is associated with the acquisition of epithelial-to-mesenchymal transition and gemcitabine sensitivity in pancreatic adenocarcinoma (Li et al, 2009;Ali et al, 2010;Bao et al, 2011). Previous studies have reported the close association of EFNB2 with the development of gastric cancer, neuroblastomas, esophageal squamous cell carcinoma, and other tumors (Tang et al, 1999(Tang et al, , 2000Kataoka et al, 2002;Tachibana et al, 2007). However, the relationship between specific genes and pancreatic adenocarcinoma has been rarely reported.…”

Section: Discussionmentioning

confidence: 99%

Integrated microRNA-mRNA analysis of pancreatic ductal adenocarcinoma

Pf¹,

Wh²,

Yt³

et al. 2015

Genet. Mol. Res.

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Section: Discussionmentioning

confidence: 99%

Integrated microRNA-mRNA analysis of pancreatic ductal adenocarcinoma

Pf¹,

Wh²,

Yt³

et al. 2015

Genet. Mol. Res.

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“…High expression levels of ephrin-B2 in malignant melanoma correlate with increased tumor vascularization and the tendency to metastasize (Vogt et al, 1998). Upregulated ephrin-B2 expression has been also correlated with the metastatic potential and progression of oesophageal squamous carcinoma (Tachibana et al, 2007). Furthermore, new evidence indicates that higher ephrin-B2 activation is correlated with increased migration and invasion of glioma cells (Nakada et al, 2009).…”

Section: Ephrin-b2 Function In Pathological Situationsmentioning

confidence: 92%

Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding

Bochenek

Dickinson

Astin

et al. 2010

Journal of Cell Science

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SummaryThe transmembrane protein ephrin-B2 regulates angiogenesis, i.e. the formation of new blood vessels through endothelial sprouting, proliferation and remodeling processes. In addition to essential roles in the embryonic vasculature, ephrin-B2 expression is upregulated in the adult at sites of neovascularization, such as tumors and wounds. Ephrins are known to bind Eph receptor family tyrosine kinases on neighboring cells and trigger bidirectional signal transduction downstream of both interacting molecules. Here we show that ephrin-B2 dynamically modulates the motility and cellular morphology of isolated endothelial cells. Even in the absence of Eph-receptor binding, ephrin-B2 stimulates repeated cycling between actomyosin-dependent cell contraction and spreading episodes, which requires the presence of the C-terminal PDZ motif. Our results show that ephrin-B2 is a potent regulator of endothelial cell behavior, and indicate that the control of cell migration and angiogenesis by ephrins might involve both receptor-dependent and receptor-independent activities.

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“…There is increased expression of genes driving migration and invasion (SERPINE2, EFNB2, ETS1, NET1, ITGB1) [40][41][42], and a decrease in differentiation associated genes that are required for epidermal development (e.g. tight junctions) (CLDN7, CRB3, DHCR24, CNN2) [43][44][45].…”

Section: Discussionmentioning

confidence: 99%

Cytoplasmic Ezrin and Moesin Correlate with Poor Survival in Head and Neck Squamous Cell Carcinoma

Brandwein-Gensler

Smith

Kawachi

et al. 2012

Head and Neck Pathol

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Members of the 4.1 superfamily of proteins, including ezrin, moesin, merlin, and willin regulate many normal physiologic processes such as cellular shape, motility, and proliferation. In addition, they contribute both to tumor development and tumor progression. We reported previously that strong cytoplasmic ezrin expression was independently associated with poorer patient survival. One hundred and thirty-one histologically confirmed primary head and neck squamous cell carcinomas were examined prospectively for cancer progression and survival at a large health care center in the Bronx, NY, USA. Immunohistochemical analysis of ezrin, moesin, merlin, and willin expression in tissue microarray samples of primary head and neck squamous cell carcinoma revealed a significant association of increased cytoplasmic ezrin with poor cancer survival. Global RNA analyses suggest that cancers with high cytoplasmic ezrin have a more invasive phenotype.This study supports our previous findings associating cytoplasmic ezrin with more aggressive behavior and poorer outcome and indicates the need for a multi-institutional study to validate the use of cytoplasmic ezrin as a biomarker for treatment planning in head and neck squamous cell carcinoma.

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Expression and prognostic significance of EFNB2 and EphB4 genes in patients with oesophageal squamous cell carcinoma

Cited by 29 publications

References 29 publications

Integrated microRNA-mRNA analysis of pancreatic ductal adenocarcinoma

Integrated microRNA-mRNA analysis of pancreatic ductal adenocarcinoma

Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding

Cytoplasmic Ezrin and Moesin Correlate with Poor Survival in Head and Neck Squamous Cell Carcinoma

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