Expression and Localization of Human Kallistatin in Rat Submandibular Gland after Intracapsular Gene Injection

Xiong, William; Chao, Julie; Chao, Lee

doi:10.1006/bbrc.1996.5946

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…This may lead to the synthesis of a protein that is therapeutic for cells 11 12 or can cause secretions to enter the circulation or saliva. 13 14 A wide range of genes, including those producing hormones, 15 16 an antibacterial agent, 17 membrane proteins, 18 19 transcription factors, 20 protease inhibitors, 21 a protein-regulating apoptosis, 22 and numerous nonmammal “reporter proteins,” are applied for salivary glands. 23 24 25…”

Section: Applications In Dentistrymentioning

confidence: 99%

Applications of Gene Therapy in Dentistry: A Review Article

Nair

Bhat

2023

Journal of Health and Allied Sciences NU

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Gene therapy promises to possess a good prospect in bridging the gap between dental applications and medicine. The dynamic therapeutic modalities of gene therapy have been advancing rapidly. Conventional approaches are being revamped to be more comprehensive and pre-emptive, which could do away with the need for surgery and medicine altogether. The complementary base sequences known as genes convey the instructions required to manufacture proteins. The oral cavity is one of the most accessible locations for the therapeutic intervention of gene therapy for several oral tissues. In 1990, the first significant trial of gene therapy was overseen to alleviate adenosine deaminase deficiency. The notion of genetic engineering has become increasingly appealing as a reflection of its benefits over conventional treatment modalities. An example of how this technology may alter dentistry is the implementation of gene therapy for dental and oral ailments. The objective of this article is to examine the effects of gene therapy on the field of dentistry, periodontology and implantology. Furthermore, the therapeutic factors of disease therapy, minimal invasion, and appropriate outcome have indeed been taken into consideration.

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Section: Applications In Dentistrymentioning

confidence: 99%

Applications of Gene Therapy in Dentistry: A Review Article

Nair

Bhat

2023

Journal of Health and Allied Sciences NU

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“…A variety of genes have been transferred including genes encoding hormones (growth hormone, insulin), 13,14 an antimicrobial agent (histatin 3, or H3), 15 membrane proteins (aquaporin-1 and aquaporin-5), 16,17 a transcription factor (E2F-1), 18 protease inhibitors (α1antitrypsin and kallistatin), 19,20 a protein affecting apoptosis (Fas ligand) 21 and several nonmammalian "reporter proteins" (ßgalactosidase, chloramphenicol transferase and luciferase). [22][23][24] For repair of damaged salivary glands, initial approach was to insert a gene encoding a water channel protein, aquaporin-1, or AQP1, into radiation-surviving (primarily ductal) salivary cells to convert these nonsecretory cells into a secretory phenotype.…”

Section: S38mentioning

confidence: 99%

Gene Therapy and its Application in Dentistry

Khandelwal

Sikdar

Diwan

et al. 2010

JIAOMR

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As evolution is a continous process with the advancement of the technology, the researches are in continuous to understand the cellular and molecular basic of every disease. As in most of the diseases conventional method is not giving satisfactory results, thus focus is on gene therapy located to treat not only inherited disease but also acquired ones. The gene therapy has broad spectrum application in the field of dentistry like in cancerous and precancerous condition, salivary gland disorders, autoimmune diseases, bone repair, DNA vaccination, etc. Thus, aim of this article is to focus in brief of the basic of gene therapy and about its applications in the field of dentistry.

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