Expression and Function of Dectin-1 is Defective in Monocytes from Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis

Abstract

The aim of this work was to study the expression and function of the innate immune receptor dectin-1 in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). We studied twenty-six patients with SLE not receiving immunosuppressive therapy, twenty-six patients with RA, and fifteen controls. We found that monocytes from SLE patients showed a diminished expression of dectin-1 compared to healthy controls, and an inverse correlation between percent of dectin-1(+) cells and the disease activity score was detected. In addition, cells from SLE patients showed an abnormal calcium flux response induced by dectin-1 ligands as well as an enhanced release of IL-1β, IL-6 and TNF-α, but not IL-23, upon dectin-1 engagement. Monocytes from patients with RA also showed a diminished expression, and a defective function of dectin-1. Our data suggest that dectin-1 receptor defects could contribute to the pathogenesis of autoimmune inflammatory conditions.

Dectin-1-mediated Signaling Leads to Characteristic Gene Expressions and Cytokine Secretion via Spleen Tyrosine Kinase (Syk) in Rat Mast Cells

“…In addition, it has been reported that Dectin-1 has relationships with not only innate immunity but also autoimmune diseases (67)(68)(69), allergic diseases (29,70), and metabolic diseases (71), indicating that mast cells may contribute to and offer new insights into these diseases.…”

Lupus erythematosus cell phenomenon in synovial and peritoneal fluids in systemic lupus erythematosus: smoking guns, crime scenes and a twist

“…The coexistence of C. parapsilosis infection in this patient could be multi‐factorial, which includes immunosuppression, neutropenia and diminished dectin‐1 expression as a pattern recognition receptor for Candida . We speculate that the presence of C. parapsilosis could have led to increased neutrophil death named ‘NETosis’ via the formation of neutrophil extracellular traps (NETs) (which comprise chromatin structures loaded with antimicrobial peptides such as LL37 in response to the infection), further contributing to the burden of extracellular DNA in this patient …”

Immune cell infiltration characteristics and related core genes in lupus nephritis: results from bioinformatic analysis

“…FCER1G, which is associated with multiple leukocyte receptor complexes and mediates signal transduction, plays a negative regulatory role in the B cell responses [34]. CLEC7A, also named as dectin-1, is a type II membrane receptor expressed in the membrane of some leukocytes and likely contributes to the synthesis of proinflammatory cytokines in autoimmune conditions [35]. MARCO, a scavenger receptor family, plays important roles in the clearance of apoptotic cells.…”