Expression and effects of B-lymphocyte stimulator and its receptors in T cell-mediated autoimmune arthritis

Cao, Yan; Sun, Xiaojing; Jia, Xiaoyi; Xu, Shu; Fang, Wei; Yang, Xiaofang; Wei, Wei

doi:10.1016/j.intimp.2015.01.001

Cited by 15 publications

(4 citation statements)

References 48 publications

(63 reference statements)

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“…Instead, injection with recombinant BAFF substantially increased the number of IL-6-expressing cells in the joint tissue, further supporting the role of BAFF as a key modulator for the cytokine milieu that affects the generation and function of Th17 cells in situ [31]. Co-culture studies with T cells and DCs have shown that pretreatment of DCs with BAFF enhances the production of IL-17 [85]. Taken together, these results suggest that BAFF may be a crucial mediator in the interaction between DCs and T cells.…”

Section: Neutrophils Macrophages and Dcs Interact With T Cellsmentioning

confidence: 85%

The role of BAFF in the progression of rheumatoid arthritis

2015

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Section: Neutrophils Macrophages and Dcs Interact With T Cellsmentioning

confidence: 85%

The role of BAFF in the progression of rheumatoid arthritis

2015

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“…Animal models have shown an unregulated expression and an increased production of BAFF at the peak of inflammation in the local synovial tissue, peripheral lymphoid organs (spleen), and immune cells (macrophages, DC, and T cell) in adjuvant‐induced arthritis in rats. Macrophages and DCs are involved in the overproduction of this cytokine, and the DCs treated with BAFF can synthesize IL‐17‐producing T cells (Chang, Sun et al, ). In collagen‐induced arthritis in rats, antibody production is correlated with BAFF level.…”

Section: The Baff/april In Ramentioning

confidence: 99%

The role of BAFF and APRIL in rheumatoid arthritis

Shabgah

Sarabi

Tavakkol‐Afshari

et al. 2019

Journal Cellular Physiology

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Development and activation of B cells quickly became clear after identifying new ligands and receptors in the tumor necrosis factor superfamily. B cell–activating factor (BAFF) and a proliferation‐inducing ligand (APRIL) are the members of membrane proteins Type 2 family released by proteolytic cleavage of furin to form active, soluble homotrimers. Except for B cells, ligands are expressed by all such immune cells like T cells, dendritic cells, monocytes, and macrophages. BAFF and APRIL have two common receptors, namely TNFR homolog transmembrane activator and Ca2+ modulator and CAML interactor (TACI) and B cell–maturation antigen. BAFF alone can also be coupled with a third receptor called BAFFR (also called BR3 or BLyS Receptor). These receptors are often expressed by immune cells in the B‐cell lineage. The binding of BAFF or APRIL to their receptors supports B cells differentiation and proliferation, immunoglobulin production and the upregulation of B cell–effector molecules expression. It is possible that the overexpression of BAFF and APRIL contributes to the pathogenesis of autoimmune diseases. In BAFF transgenic mice, there is a pseudo‐autoimmune manifestation, which is associated with an increase in B‐lymphocytes, hyperglobulinemia, anti‐single stranded DNA, and anti‐double‐stranded DNA antibodies, and immune complexes in their peripheral blood. Furthermore, overexpressing BAFF augments the number of peripheral B220+ B cells with a normal proliferation rate, high levels of Bcl2, and prolonged survival and hyperactivity. Therefore, in this review article, we studied BAFF and APRIL as important mediators in B‐cell and discussed their role in rheumatoid arthritis.

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“…Although the exact cause of RA is uncertain, many experts agree that the deterioration of the joint's bone and cartilage is caused by activated inflammatory T cells, B cells, and macrophages infiltrating the synovium (6) .These inflammatory cells release various pro-inflammatory cytokines and mediators, which cause severe tissue damages and secondary inflammatory injuries in arthritis (7) . Besides, T cells also initiate the autoimmune process and mediate chronic synovitis, leading to joint destruction (8) .…”

Section: Introductionmentioning

confidence: 99%

Structural and Ultrastructural Examination of Anti-Arthritic Effect of Bee Venom in Temporomandibular Joint with Induced Rheumatoid Arthritis in Albino Rats

shafie

Hegazy

Youssef

2022

Dental Science Updates

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Introduction: Bee venom is broadly utilized in conventional Chinese medication for the treatment of fiery maladies, such as rheumatoid arthritis and to lighten the related pain. Aim: This research aimed to investigate the anti-arthritic impact of bee venom in repairing the possible structural and ultrastructural changes in the temporomandibular joint of albino rats with induce rheumatoid arthritis. Material and Methods: Thirty adult male albino rats were used in this investigation. The animals were divided into; Group 1: (n=10) served as negative control; Group 2: (n=20) they received 7 intraarticular injections of 0.02 ml of carrageenan solution in order to induce Rheumatoid Arthritis. Then after, the animals of group 2 were divided equally into; Subgroup 2.1: served as positive controls; Subgroup 2.2: were treated by subcutaneous injection of 0.2ml of bee venom solution for 12 weeks. At the end of the experiment the rats of different groups were euthanized then the head of each animal was divided sagittally into two halves; the right halves of all groups were used for structural examination while the left halves were used for ultrastructural examination. Results: Biochemical results revealed subgroup 2.2 showed a significant decrease in the values compared with subgroup 2.1. Histological and electron microscopic examination of the present sections of subgroup 2.1 showed variable microscopically degenerative changes compared to control group 1; while the present sections of subgroups 2.2 revealed marked improvement of the different components of rat's temporomandibular joint. Conclusion: Bee venom have antiarthritic effect in arthritic rat's temporomandibular joint.

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Expression and effects of B-lymphocyte stimulator and its receptors in T cell-mediated autoimmune arthritis

Cited by 15 publications

References 48 publications

The role of BAFF in the progression of rheumatoid arthritis

The role of BAFF in the progression of rheumatoid arthritis

The role of BAFF and APRIL in rheumatoid arthritis

Structural and Ultrastructural Examination of Anti-Arthritic Effect of Bee Venom in Temporomandibular Joint with Induced Rheumatoid Arthritis in Albino Rats

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