The role of BAFF in the progression of rheumatoid arthritis

Fang, Wei; Cao, Yan; Wei, Wei

doi:10.1016/j.cyto.2015.07.014

Cited by 77 publications

(114 citation statements)

References 102 publications

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“…Moreover, their diferentiation and survival are driven by positive feedback loops induced by cytokines, especially members belonging to the tumor necrosis factor (TNF) family [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…Recent data highlighted the role of signaling crosstalk in B-lymphocytes, particularly of B-cell-activating factor (BAFF) and its receptors in early steps of the disease, advancing clinical development of BAFF antagonists for the treatment of RA [2][3][4][5]. Acting as an innate cytokine mediator, BAFF is known to modulate peripheral B-and T-cell homeostasis, promoting speciic downstream signaling events through three diferent types of receptors [2,4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Acting as an innate cytokine mediator, BAFF is known to modulate peripheral B-and T-cell homeostasis, promoting speciic downstream signaling events through three diferent types of receptors [2,4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Abnormal BAFF/BAFF receptor-signaling pathways were reported in several autoimmune disorders including systemic lupus erythematosus, Sjogren's syndrome, ANCA-associated vasculitis, and RA [2,4,5]. Of interest, elevated BAFF levels were detected in synovial luid, serum, and saliva in very early stages of RA, suggesting its involvement in cell-cell interactions network in the synovial microenvironment, as well as B-cell activation and the development of autoreactive B cells [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…Of interest, elevated BAFF levels were detected in synovial luid, serum, and saliva in very early stages of RA, suggesting its involvement in cell-cell interactions network in the synovial microenvironment, as well as B-cell activation and the development of autoreactive B cells [2][3][4]. Furthermore, the overexpression of BAFF receptors, as well as disturbed autocrine and paracrine BAFF network, seems to be related to inlammatory events and RA progression [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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BAFF System in Rheumatoid Arthritis: from Pathobiology to Therapeutic Targets

Ancuţa¹,

Pomirleanu²,

Mihailov³

et al. 2017

New Developments in the Pathogenesis of Rheumatoid Arthritis

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Recent advances in understanding the multifaceted pathobiology of rheumatoid arthritis have highlighted the pivotal role and continuing crosstalk between activated immune cells, pro-inlammatory cytokines, and matrix-degrading mediators, promoting chronic inlammation as well as irreversible tissue damage within an autoimmune background.B cells are widely recognized as leading players in immune-mediated pathology based on their ability to produce not only diferent paterns of autoantibodies and driving cyto-

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

BAFF System in Rheumatoid Arthritis: from Pathobiology to Therapeutic Targets

Ancuţa¹,

Pomirleanu²,

Mihailov³

et al. 2017

New Developments in the Pathogenesis of Rheumatoid Arthritis

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Correlation of APRIL with production of inflammatory cytokines during acute malaria in the Brazilian Amazon

Pinna

Santos

Perce-da-Silva

et al. 2018

Immunity Inflam & Disease

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IntroductionA proliferation‐inducing ligand (APRIL) and B cell activation factor (BAFF) are known to play a significant role in the pathogenesis of several diseases, including BAFF in malaria. The aim of this study was to investigate whether APRIL and BAFF plasma concentrations could be part of inflammatory responses associated with P. vivax and P. falciparum malaria in patients from the Brazilian Amazon.MethodsBlood samples were obtained from P. vivax and P. falciparum malaria patients (n = 52) resident in Porto Velho before and 15 days after the beginning of treatment and from uninfected individuals (n = 12). We investigated APRIL and BAFF circulating levels and their association with parasitaemia, WBC counts, and cytokine/chemokine plasma levels. The expression levels of transmembrane activator and calcium‐modulating cyclophilin ligand interactor (TACI) on PBMC from a subset of 5 P. vivax‐infected patients were analyzed by flow cytometry.ResultsAPRIL plasma levels were transiently increased during acute P. vivax and P. falciparum infections whereas BAFF levels were only increased during acute P. falciparum malaria. Although P. vivax and P. falciparum malaria patients have similar cytokine profiles during infection, in P. vivax acute phase malaria, APRIL but not BAFF levels correlated positively with IL‐1, IL‐2, IL‐4, IL‐6, and IL‐13 levels. We did not find any association between P. vivax parasitaemia and APRIL levels, while an inverse correlation was found between P. falciparum parasitaemia and APRIL levels. The percentage of TACI positive CD4+ and CD8+ T cells were increased in the acute phase P. vivax malaria.ConclusionThese findings suggest that the APRIL and BAFF inductions reflect different host strategies for controlling infection with each malaria species.

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NF‐κB signaling in inflammation and cancer

Zhang

et al. 2021

MedComm

204

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Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered in 1986, extraordinary efforts have been made to understand the function and regulating mechanism of NF‐κB for 35 years, which lead to significant progress. Meanwhile, the molecular mechanisms regulating NF‐κB activation have also been illuminated, the cascades of signaling events leading to NF‐κB activity and key components of the NF‐κB pathway are also identified. It has been suggested NF‐κB plays an important role in human diseases, especially inflammation‐related diseases. These studies make the NF‐κB an attractive target for disease treatment. This review aims to summarize the knowledge of the family members of NF‐κB, as well as the basic mechanisms of NF‐κB signaling pathway activation. We will also review the effects of dysregulated NF‐κB on inflammation, tumorigenesis, and tumor microenvironment. The progression of the translational study and drug development targeting NF‐κB for inflammatory diseases and cancer treatment and the potential obstacles will be discussed. Further investigations on the precise functions of NF‐κB in the physiological and pathological settings and underlying mechanisms are in the urgent need to develop drugs targeting NF‐κB for inflammatory diseases and cancer treatment, with minimal side effects.

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The role of BAFF in the progression of rheumatoid arthritis

Cited by 77 publications

References 102 publications

BAFF System in Rheumatoid Arthritis: from Pathobiology to Therapeutic Targets

BAFF System in Rheumatoid Arthritis: from Pathobiology to Therapeutic Targets

Correlation of APRIL with production of inflammatory cytokines during acute malaria in the Brazilian Amazon

NF‐κB signaling in inflammation and cancer

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