Expression and Distribution of CD44 and Hyaluronic Acid in Human Vocal Fold Mucosa

Sato, Kiminori; Sakamoto, Kikuo; Nakashima, Tadashi

doi:10.1177/000348940611501005

Cited by 32 publications

(28 citation statements)

References 26 publications

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“…Glycosaminoglycan is situated around the VFSCs, but not abundant, in the human newborn MFe. The percentage of CD44-positive cells in the newborn MFe is not very high, and 34.5 8 4.4% VFSCs are stained with CD44 [12] . About 55% of the fibroblasts in the newborn lamina propria are stained with CD44 [12] .…”

Section: Fine Structure Of Newborn Mfe and Vfmmentioning

confidence: 89%

“…The percentage of CD44-positive cells in the newborn MFe is not very high, and 34.5 8 4.4% VFSCs are stained with CD44 [12] . About 55% of the fibroblasts in the newborn lamina propria are stained with CD44 [12] . In the newborn VFM, before the appearance and distribution of hyaluronic acid, CD44 is expressed in one third of the VFSCs in the MF and one half of the fibroblasts in Reinke's space.…”

Section: Fine Structure Of Newborn Mfe and Vfmmentioning

confidence: 89%

“…Almost all of the VFSCs in the child MFe show CD44 expression and a large amount of hyaluronic acid is present immediately adjacent to VFSCs in the child MFe. On the other hand, CD44-positive fibroblasts are sparse (5.6 8 3.0%) in the lamina propria of the child VFM [12] . These findings are the same as those in adults.…”

Section: Fine Structure Of Child Mfe and Vfmmentioning

confidence: 95%

“…Most of the VFSCs (94.7 8 1.9%) in the child MFe are stained with CD44 [12] . Almost all of the VFSCs in the child MFe show CD44 expression and a large amount of hyaluronic acid is present immediately adjacent to VFSCs in the child MFe.…”

Section: Fine Structure Of Child Mfe and Vfmmentioning

confidence: 99%

“…The percentage of CD44-positive cells in the infant macula flava becomes larger, and 87.2 8 3.0% of the stellate cells are stained with CD44 [12] . However, CD44-positive fibroblasts become sparse (1.9 8 2.0%) in the infant lamina propria of the VFM [12] . The expression of CD44 and the distribution of hyaluronic acid are the same as in the adult VFM.…”

Section: Fine Structure Of Infant Mfe and Vfm ( Fig 2 B ) [19]mentioning

confidence: 99%

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Functional Histology of the Macula Flava in the Human Vocal Fold – Part 2: Its Role in the Growth and Development of the Vocal Fold

Sato

Umeno²,

Nakashima³

2010

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Objective: This study aims to clarify the role of the maculae flavae (MFe) during growth and development of the human vocal fold mucosa (VFM). Methods: Our current results concerning the MFe in the human newborn, infant, and child VFM are summarized. Results: Newborns already had immature MFe at the same sites as adults. They were composed of dense masses of vocal fold stellate cells (VFSCs), whereas extracellular matrix components were sparse. VFSCs in the newborn MFe had already started synthesizing extracellular matrices (EM). During infancy, the EM synthesized in the MFe appeared in the VFM to initiate the formation of the three-dimensional extracellular matrix structure of the human VFM. During childhood, MFe including VFSCs continued to synthesize EM such as collagenous, reticular, and elastic fibers, and hyaluronic acid (glycosaminoglycan), which are essential for the human VFM as a vibrating tissue. The MFe in newborns, infants and children were related to the growth and development of the human VFM. Conclusion: Human MFe including VFSCs were inferred to be involved in the metabolism of EM, essential for the viscoelasticity of the human VFM, and are considered to be an important structure in the growth and development of the human VFM.

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Section: Fine Structure Of Newborn Mfe and Vfmmentioning

confidence: 89%

Section: Fine Structure Of Newborn Mfe and Vfmmentioning

confidence: 89%

Section: Fine Structure Of Child Mfe and Vfmmentioning

confidence: 95%

Section: Fine Structure Of Child Mfe and Vfmmentioning

confidence: 99%

Section: Fine Structure Of Infant Mfe and Vfm ( Fig 2 B ) [19]mentioning

confidence: 99%

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