Stellate cells in the human child vocal fold macula flava

Sato, Kiminori; Nakashima, Tadashi

doi:10.1002/lary.20010

Cited by 14 publications

(18 citation statements)

References 28 publications

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“…1,2 VFSCs, which are interstitial cells with a star-like appearance and are dense in the human MFe, were discovered in our previous studies. 3,9,[16][17][18][19] The VFSCs possess lipid droplets and store vitamin A. The VFSCs had many morphological differences with conventional fibroblasts in the vocal fold mucosa and constantly synthesized extracellular matrices that are essential for the viscoelasticity of the human vocal fold mucosa.…”

Section: The Role Of Mfe and Vocal Fold Stellate Cells In The Human Vmentioning

confidence: 99%

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Histopathologic Investigations of the Unphonated Human Child Vocal Fold Mucosa

et al. 2012

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Section: The Role Of Mfe and Vocal Fold Stellate Cells In The Human Vmentioning

confidence: 99%

“…NCVF, normal child vocal fold; UPCVF, unphonated child vocal fold; NS, not significant. *Data from Sato et al9 …”

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Histopathologic Investigations of the Unphonated Human Child Vocal Fold Mucosa

et al. 2012

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“…The percentages of CD44-positive VFSCs in the maculae flavae (Fig 3) and fibroblasts in the lamina propria of the unphonated child vocal fold mucosa were extremely low (Fig 4 12,13 ), and 1.2% ± 0.9% (mean ± SD) of the VFSCs in the maculae flavae and 3.7% ± 4.1% of the fibroblasts in the lamina propria were stained with CD44 (Fig 4) Comparison Between Unphonated and Normal Human Vocal Fold Mucosae. The lamina propria of the child and adult normal vocal fold mucosae were stained light blue with Alcian blue at pH 2.5; in particular, the maculae flavae were strongly stained.…”

Section: Unphonated Human Child Vocal Fold Mucosamentioning

confidence: 99%

Expression and Distribution of Hyaluronic Acid and CD44 in Unphonated Human Vocal Fold Mucosa

Sato¹,

Umeno²,

Nakashima³

et al. 2010

Ann Otol Rhinol Laryngol

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Objectives: The tension caused by phonation (vocal fold vibration) is hypothesized to stimulate vocal fold stellate cells (VFSCs) in the maculae flavae (MFe) to accelerate production of extracellular matrices. The distribution of hyaluronic acid (HA) and expression of CD44 (a cell surface receptor for HA) were examined in human vocal fold mucosae (VFMe) that had remained unphonated since birth. Methods: Five specimens of VFMe (3 adults, 2 children) that had remained unphonated since birth were investigated with Alcian blue staining, hyaluronidase digestion, and immunohistochemistry for CD44. Results: The VFMe containing MFe were hypoplastic and rudimentary. The VFMe did not have a vocal ligament, Reinke's space, or a layered structure, and the lamina propria appeared as a uniform structure. In the children, HA was distributed in the VFMe containing MFe. In the adults, HA had decreased in the VFMe containing MFe. In both groups, the VFSCs in the MFe and the fibroblasts in the lamina propria expressed little CD44. Conclusions: This study supports the hypothesis that the tensions caused by vocal fold vibration stimulate the VFSCs in the MFe to accelerate production of extracellular matrices and form the layered structure. Phonation after birth is one of the important factors in the growth and development of the human VFMe.

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“…( fig. 2 C ) [21] There are collagenous, reticular and elastic fibers in the lamina propria of the child VFM. Vocal ligament and layered structure are not present in the lamina propria of the child VFM.…”

Section: Fine Structure Of Infant Mfe and Vfm ( Fig 2 B ) [19]mentioning

confidence: 99%

Functional Histology of the Macula Flava in the Human Vocal Fold – Part 2: Its Role in the Growth and Development of the Vocal Fold

Sato

Umeno²,

Nakashima³

2010

Folia Phoniatr Logop

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Objective: This study aims to clarify the role of the maculae flavae (MFe) during growth and development of the human vocal fold mucosa (VFM). Methods: Our current results concerning the MFe in the human newborn, infant, and child VFM are summarized. Results: Newborns already had immature MFe at the same sites as adults. They were composed of dense masses of vocal fold stellate cells (VFSCs), whereas extracellular matrix components were sparse. VFSCs in the newborn MFe had already started synthesizing extracellular matrices (EM). During infancy, the EM synthesized in the MFe appeared in the VFM to initiate the formation of the three-dimensional extracellular matrix structure of the human VFM. During childhood, MFe including VFSCs continued to synthesize EM such as collagenous, reticular, and elastic fibers, and hyaluronic acid (glycosaminoglycan), which are essential for the human VFM as a vibrating tissue. The MFe in newborns, infants and children were related to the growth and development of the human VFM. Conclusion: Human MFe including VFSCs were inferred to be involved in the metabolism of EM, essential for the viscoelasticity of the human VFM, and are considered to be an important structure in the growth and development of the human VFM.

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Stellate cells in the human child vocal fold macula flava

Abstract: The SCs in the child MF constantly synthesized EM, essential for viscoelastic properties of the lamina propria of the human VFM, in the stage of vocal fold growth and development. The SCs in the MF were inferred to be involved in the growth and development of human VFM.

Cited by 14 publications

References 28 publications

Histopathologic Investigations of the Unphonated Human Child Vocal Fold Mucosa

Histopathologic Investigations of the Unphonated Human Child Vocal Fold Mucosa

Expression and Distribution of Hyaluronic Acid and CD44 in Unphonated Human Vocal Fold Mucosa

Functional Histology of the Macula Flava in the Human Vocal Fold – Part 2: Its Role in the Growth and Development of the Vocal Fold

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