Expression and Cellular Localization of IFITM1 in Normal and Injured Rat Spinal Cords

Wang, Ying; Lin, Yuhong; Yan, Wei; Yao, Zong-Feng; Tang, Jie; Shen, Lin; Wang, Rui; Ding, Songtao; Hu, Jianguo; Lü, He‐Zuo

doi:10.1369/0022155417749491

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…IFITM1 was expressed in intraspinal leukocytes and activated microglia, suggesting possible involvement in the pathological process of pain. 43 In a preclinical SCI model, IRF1 colocalized in the spinal cord with activated caspase-3, and thus may play a role in neuronal apoptosis. 44 Some of the other genes that were highly correlated with pain intensity (e.g.…”

Section: Discussionmentioning

confidence: 99%

Systemic gene expression profiles according to pain types in individuals with chronic spinal cord injury

et al. 2021

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Pain affects most individuals with traumatic spinal cord injury (SCI). Major pain types after SCI are neuropathic or nociceptive, often experienced concurrently. Pain after SCI may be refractory to treatments and negatively affects quality of life. Previously, we analyzed whole blood gene expression in individuals with chronic SCI compared to able-bodied (AB) individuals. Most participants with SCI reported pain (N = 19/28). Here, we examined gene expression of participants with SCI by pain status. Compared to AB, participants with SCI with pain had 468 differentially expressed (DE) genes; participants without pain had 564 DE genes (FDR < 0.05). Among DE genes distinct to participants with SCI with pain, Gene Ontology Biological Process (GOBP) analysis showed upregulated genes were enriched in categories related to T cell activation or inflammation; downregulated genes were enriched in categories related to protein proteolysis and catabolism. Although most participants with pain reported multiple pain types concurrently, we performed a preliminary comparison of gene expression by worst pain problem type. Compared to AB, participants with SCI who ranked neuropathic (N = 9) as worst had one distinct DE gene (TMEM156); participants who ranked nociceptive (N = 10) as worst had 61 distinct DE genes (FDR < 0.05). In the nociceptive group, the GOBP category with the lowest P-value identified among upregulated genes was “positive regulation of T cell activation”; among downregulated genes it was “receptor tyrosine kinase binding”. An exploratory comparison of pain groups by principal components analysis also showed that the nociceptive group was enriched in T-cell related genes. A correlation analysis identified genes significantly correlated with pain intensity in the neuropathic or nociceptive groups (N = 145, 65, respectively, Pearson’s correlation r > 0.8). While this pilot study highlights challenges of identifying gene expression profiles that correlate with specific types of pain in individuals with SCI, it suggests that T-cell signaling should be further investigated in this context.

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Section: Discussionmentioning

confidence: 99%

Systemic gene expression profiles according to pain types in individuals with chronic spinal cord injury

et al. 2021

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“…Activated microglia can also promote a reactive astrocyte-mediated tissue necrosis response through the TLR/MyD88 signaling pathway, inducing cavity formation and exacerbating secondary injury in SCI ( 80 ). Furthermore, after SCI, interferon-induced transmembrane protein 1 is rapidly increased in infiltrating leukocytes, activated microglia, and astrocytes, impeding the recovery of neurological function after injury ( 81 ). Microglia can also positively affect astrocytes and oligodendrocytes.…”

Section: Discussionmentioning

confidence: 99%

Immunoregulation of Glia after spinal cord injury: a bibliometric analysis

Huang,

Hu,

et al. 2024

Front. Immunol.

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ObjectiveImmunoregulation is a complex and critical process in the pathological process of spinal cord injury (SCI), which is regulated by various factors and plays an important role in the functional repair of SCI. This study aimed to explore the research hotspots and trends of glial cell immunoregulation after SCI from a bibliometric perspective.MethodsData on publications related to glial cell immunoregulation after SCI, published from 2004 to 2023, were obtained from the Web of Science Core Collection. Countries, institutions, authors, journals, and keywords in the topic were quantitatively analyzed using the R package “bibliometrix”, VOSviewer, Citespace, and the Bibliometrics Online Analysis Platform.ResultsA total of 613 papers were included, with an average annual growth rate of 9.39%. The papers came from 36 countries, with the United States having the highest output, initiating collaborations with 27 countries. Nantong University was the most influential institution. We identified 3,177 authors, of whom Schwartz, m, of the Weizmann Institute of Science, was ranked first regarding both field-specific H-index (18) and average number of citations per document (151.44). Glia ranked first among journals with 2,574 total citations. The keywords “microglia,” “activation,” “macrophages,” “astrocytes,” and “neuroinflammation” represented recent hot topics and are expected to remain a focus of future research.ConclusionThese findings strongly suggest that the immunomodulatory effects of microglia, astrocytes, and glial cell interactions may be critical in promoting nerve regeneration and repair after SCI. Research on the immunoregulation of glial cells after SCI is emerging, and there should be greater cooperation and communication between countries and institutions to promote the development of this field and benefit more SCI patients.

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“…In this regard, it is logical to assume that such a technique of transplanting astrocyte progenitor stem cells will be useful in the treatment of stroke, Alzheimer's and Parkinson's diseases. When analyzing the current literature and the latest developments in this field, we cannot ignore the effect of melatonin on the proliferation and differentiation of neural stem cells, which are self-healing, pluripotent and undifferentiated cells [37,38].…”

Section: Astrocyte Transplantation and The Melatonin Effectmentioning

confidence: 99%

Astrocytes and their Phenomenal Possibilities in the Treatment of Various Neurodegenerative Disorders: An Overview

Maslova

Bazaeva

Abdullaeva

et al. 2021

JPRI

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At present, research in the field of the brain does not cease to surprise us with new facts and discoveries that no one could have suspected about 30 years ago. But it was at the time when it became clear that the cerebral neurons are not the only cells that can respond to changes in the external environment. A real scientific boom began to study a heterogeneous group called glia. And scientists are paying close attention to the largest of them – astrocytes. Understanding the importance of astrocytes in the mechanisms of repair and damage to brain cells in various forms of CNS pathology determines the possibility of targeted search for drugs that affect the rate of development of reactive astrogliosis in response to various brain injuries. At the same time, pharmacological modulation of activated astrocytes and other components of glia can be an integral part of the therapy of neurological diseases.

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Expression and Cellular Localization of IFITM1 in Normal and Injured Rat Spinal Cords

Cited by 4 publications

References 43 publications

Systemic gene expression profiles according to pain types in individuals with chronic spinal cord injury

Systemic gene expression profiles according to pain types in individuals with chronic spinal cord injury

Immunoregulation of Glia after spinal cord injury: a bibliometric analysis

Astrocytes and their Phenomenal Possibilities in the Treatment of Various Neurodegenerative Disorders: An Overview

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