Expression and Activity of Heme Oxygenase-1 in Artificially Induced Low-Flow Priapism in Rat Penile Tissues

Jin, Yong; Gam, Sung Chul; Jung, Jae Hun; Hyun, Jung Suk; Chang, Ki Churl; Hyun, Jae Seog

doi:10.1111/j.1743-6109.2008.00886.x

Cited by 28 publications

(34 citation statements)

References 29 publications

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“…Heme oxygenase (HO) is a critical enzyme that catalyzes the degradation of heme, a vasculotoxic and oxidative breakdown product of hemoglobin, to bilverdin, iron, and carbon monoxide (CO) [66–68]. HO exists as three isoforms: HO-1, an inducible form, ubiquitously present in endothelium and smooth muscle, that reacts to a variety of stress mediators such as heat and NO donors; HO-2, a constitutive form; and HO-3, which is not expressed in humans [66, 67].…”

Section: Molecular Mechanisms Of Priapism Pathophysiology (Figure 1)mentioning

confidence: 99%

“…HO exists as three isoforms: HO-1, an inducible form, ubiquitously present in endothelium and smooth muscle, that reacts to a variety of stress mediators such as heat and NO donors; HO-2, a constitutive form; and HO-3, which is not expressed in humans [66, 67]. Among other roles, HO-1 is thought to have antioxidant properties as it is up-regulated in vascular smooth muscle cells, endothelial cells, and cardiac tissue in settings of hypoxia [66, 68]. HO-1 up-regulation has also been observed in cavernosal tissues of artificially-induced, animal priapic models [66].…”

Section: Molecular Mechanisms Of Priapism Pathophysiology (Figure 1)mentioning

confidence: 99%

“…Among other roles, HO-1 is thought to have antioxidant properties as it is up-regulated in vascular smooth muscle cells, endothelial cells, and cardiac tissue in settings of hypoxia [66, 68]. HO-1 up-regulation has also been observed in cavernosal tissues of artificially-induced, animal priapic models [66]. This effect of HO-1 induction was shown to be local and time-dependent, with activity gradually increasing in time intervals evaluated from 0 to 24 hours [66].…”

Section: Molecular Mechanisms Of Priapism Pathophysiology (Figure 1)mentioning

confidence: 99%

“…HO-1 up-regulation has also been observed in cavernosal tissues of artificially-induced, animal priapic models [66]. This effect of HO-1 induction was shown to be local and time-dependent, with activity gradually increasing in time intervals evaluated from 0 to 24 hours [66]. …”

Section: Molecular Mechanisms Of Priapism Pathophysiology (Figure 1)mentioning

confidence: 99%

“…Specifically, the resulting CO produced from the HO reaction has been shown to promote relaxation in stimulated human cavernosal tissues [66]. CO can stimulate soluble guanylyl cyclase (sGC) in the setting of decreased NO bioavailability, resulting in increased cGMP production; however, CO can also inhibit sGC in the presence of high NO levels [67].…”

Section: Molecular Mechanisms Of Priapism Pathophysiology (Figure 1)mentioning

confidence: 99%

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Molecular Pathophysiology of Priapism: Emerging Targets

Anele¹,

Morrison²,

Burnett³

2015

CDT

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Priapism is an erectile disorder involving uncontrolled, prolonged penile erection without sexual purpose, which can lead to erectile dysfunction. Ischemic priapism, the most common of the variants, occurs with high prevalence in patients with sickle cell disease. Despite the potentially devastating complications of this condition, management of recurrent priapism episodes historically has commonly involved reactive treatments rather than preventative strategies. Recently, increasing elucidation of the complex molecular mechanisms underlying this disorder, principally involving dysregulation of nitric oxide signaling, has allowed for greater insights and exploration into potential therapeutic targets. In this review, we discuss the multiple molecular regulatory pathways implicated in the pathophysiology of priapism. We also identify the roles and mechanisms of molecular effectors in providing the basis for potential future therapies.

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Section: Molecular Mechanisms Of Priapism Pathophysiology (Figure 1)mentioning

confidence: 99%

Section: Molecular Mechanisms Of Priapism Pathophysiology (Figure 1)mentioning

confidence: 99%

Section: Molecular Mechanisms Of Priapism Pathophysiology (Figure 1)mentioning

confidence: 99%

Section: Molecular Mechanisms Of Priapism Pathophysiology (Figure 1)mentioning

confidence: 99%

Section: Molecular Mechanisms Of Priapism Pathophysiology (Figure 1)mentioning

confidence: 99%

See 3 more Smart Citations

Molecular Pathophysiology of Priapism: Emerging Targets

Anele¹,

Morrison²,

Burnett³

2015

CDT

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Penile Priapism, Clitoral Priapism, and Persistent Genital Arousal Disorder: A Contemporary Review

Yafi

April

Powers

et al. 2015

Sexual Medicine Reviews

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Stuttering Priapism: Insights into Pathogenesis and Management

Morrison

Burnett

2012

Curr Urol Rep

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Priapism is defined as a persistent, painful erection that continues beyond, or is unrelated to, sexual stimulation. It may be categorized as either ischemic (low/absent flow) or nonischemic (high flow). Stuttering priapism is a variant of the ischemic type that is characterized by repetitive, transient, painful, self-limiting episodes of priapism. It is associated with various hematological disorders, including sickle cell disease and pharmacological treatments. The consequences of ineffective treatment of priapism are erectile dysfunction and impaired quality of life due to chronic pain and physical disfigurement. Many of the existing medical therapeutic options for treatment of stuttering priapism are nonmechanistic and associated with significant adverse effects. However, the scientific knowledge of stuttering priapism has transitioned in the past few years, from a condition that is poorly understood to one that has borne a burst of evolving molecular science. In this review, the pathophysiology of priapism is discussed, with particular emphasis on new molecular effectors and mechanisms. Novel treatment methods, as well as potential future agents, based on the emerging molecular evidence are discussed.

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Expression and Activity of Heme Oxygenase-1 in Artificially Induced Low-Flow Priapism in Rat Penile Tissues

Cited by 28 publications

References 29 publications

Molecular Pathophysiology of Priapism: Emerging Targets

Molecular Pathophysiology of Priapism: Emerging Targets

Penile Priapism, Clitoral Priapism, and Persistent Genital Arousal Disorder: A Contemporary Review

Stuttering Priapism: Insights into Pathogenesis and Management

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