Expression analysis of long non-coding A T B and its putative target in breast cancer

Nikpayam, Elahe; Soudyab, Mohammad; Tasharrofi, Behnoosh; Sarrafzadeh, Shaghayegh; Iranpour, Mostafa; Geranpayeh, Lobat; Mirfakhraie, Reza; Gharesouran, Jalal; Ghafouri‐Fard, Soudeh

doi:10.3233/bd-160264

Cited by 23 publications

(13 citation statements)

References 14 publications

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“…The critical roles of lncRNAs in regulation of genes involved in DNA repair [14], induction of epithelial to mesenchymal transition (EMT) [15,16], inhibition of tumor suppressors [17,18], control of apoptosis and cellular metabolism [19] and regulation of nuclear receptors function [20] potentiate them as molecular markers of cancer. Expression levels of several lncRNAs have been assessed in lung cancer specimens and cell lines.…”

Section: Discussionmentioning

confidence: 99%

Expression Analysis of OIP5-AS1 in Non-Small Cell Lung Cancer

Esfandi¹,

Oskooei²,

Taheri³

et al. 2018

Klin Onkol

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Background: Lung cancer as the most fatal cancer of men has prompted researchers to find bio markers for early detection and prognosis. Among the possible bio markers are a group of non-coding transcripts with sizes more than 200 nucleotides called long non-coding RNAs (lncRNAs). Aims: In the present study, we evaluated the expression levels of the lncRNA OIP5 antisense RNA 1 (OIP5-AS1) in 32 non-small cell lung cancer (NSCLC) samples compared with their corresponding adjacent non-cancerous tissue (ANCTs) by means of real-time polymerase chain reaction. The samples were obtained from patients who were admitted at Labbafi-Nejad Hospital during 2015 and 2016. Results: OIP5-AS expression levels was significantly decreased in tumoral tissues compared with ANCTs in total samples and in male subgroup. However, no association was found between relative expression of OIP5-AS1 and clinicopathological data of patients or history of smoking. Expression levels of this lncRNA were not correlated with patients' age. Conclusions: This lncRNA is possibly a novel bio marker of NSCLC in Iranian patients. Future studies are needed to confirm the results of our study in larger sample sizes. Moreover, based on the difference in lung cancer associated risk factors in different populations, population-based studies are needed to explore the role of this lncRNA in the pathogenesis of cancers in each region to design appropriate targeted therapies for each population.

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Section: Discussionmentioning

confidence: 99%

Expression Analysis of OIP5-AS1 in Non-Small Cell Lung Cancer

Esfandi¹,

Oskooei²,

Taheri³

et al. 2018

Klin Onkol

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“…Subsequently, they affect telomere biology, chromatin dynamics, genome structure organization [7], DNA repair [8] and tissue homeostasis [9]. They also participate in tumorigenesis process via different mechanisms, such as transcription repression [10], induction of epithelial-mesenchymal transition (EMT) [11], inhibition of tumor suppressors expression [12,13], over-expression of certain oncogenes [14,15], regulation of tumor-associated signal ing pathways [16] as well as modulation of tumor microenvironment [17]. Recently, a handful of lncRNAs have been shown to regulate the MAPK pathway through modulation of the expression of different proteins within this pathway.…”

Section: Introductionmentioning

confidence: 99%

Long Non-coding RNAs as Regulators of the Mitogen-activated Protein Kinase (MAPK) Pathway in Cancer

Tasharrofi¹,

Ghafouri‐Fard²

2018

Klin Onkol

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Considering the role of this pathway in the pathogenesis of several cancers, alterations in lncRNA expression lead to changes in MAPK pathway resulting in inhibition of apoptosis and induction of cell proliferation and migration. Moreover, some lncRNAs participate in cross-talk between MAPK and other cancer-related pathways, such as PI3K/Akt pathway through regulation of certain shared proteins between these pathways. Based on the availability of certain anticancer drugs that modulate this pathway, identification of lncRNAs that affect this pathway would help in establishment of effective therapies.Key words: RNA - long noncoding - mitogen-activated protein kinases - signal transduction.

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“…Breast cancer is a prevalent cancer among women with a huge disease burden, which has been attributed to the lack of suitable biomarkers for the early detection of disease. 1 Despite several efforts to find diagnostic and prognostic biomarkers for breast cancer, 2 – 4 the clinical relevance of few biomarkers has been confirmed. 5 Vitamin D receptor (VDR) signaling pathway has been regarded as a putative biomarker and therapeutic target in breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Assessment of functional variants and expression of long noncoding RNAs in vitamin D receptor signaling in breast cancer

Oskooei¹,

Geranpayeh²,

Omrani³

et al. 2018

CMAR

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PurposeVitamin D receptor (VDR) signaling pathway is implicated in the pathogenesis of breast cancer.Patients and methodsWe selected VDR-associated long noncoding RNAs (lncRNAs) through an in silico analysis of available microarray and RNA-sequencing data and assessed their expression in 75 breast tumor samples and their adjacent noncancerous tissues (ANCTs). We also genotyped two functional polymorphisms within VDR gene in all patients.ResultsVDR, MALAT1, and LINC00511 were significantly upregulated in tumoral tissues compared with ANCTs (fold change [FC] =1.85, P=0.03; FC =1.54, P=0.04; and FC =4.75, P=0.000, respectively). In patients younger than 55 years, significant associations were found between expression levels of both SNHG16 and LINC00511 genes and nuclear grade (P=0.03), expression of LINC00346 and tubule formation (P=0.01), expression of both SNHG16 and SNHG6 genes and family history of cancer (P=0.01 and 0.03, respectively), as well as expression of VDR and progesterone receptor status (P=0.03). We detected significant correlations between expression levels of VDR and SNHG16 in both tumoral tissues and ANCTs. The TT genotype of FokI polymorphism was associated with the higher expression levels of VDR. FokI variants were associated with expression levels of both MALAT1 and SNHG16 in ANCTs (P=0.01 and 0.03, respectively). CdxII variants were associated with expression levels of SNHG16 in ANCTs. A significant correlation was found between FC values of SNHG16 expression and vitamin D levels.ConclusionThe present study provides further evidence for the contribution of VDR signaling and the related lncRNAs in the pathogenesis of breast cancer and introduces some novel lncRNAs as putative molecules in the interactive functional network of VDR signaling in breast cancer.

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Expression analysis of long non-coding A T B and its putative target in breast cancer

Cited by 23 publications

References 14 publications

Expression Analysis of OIP5-AS1 in Non-Small Cell Lung Cancer

Expression Analysis of OIP5-AS1 in Non-Small Cell Lung Cancer

Long Non-coding RNAs as Regulators of the Mitogen-activated Protein Kinase (MAPK) Pathway in Cancer

Assessment of functional variants and expression of long noncoding RNAs in vitamin D receptor signaling in breast cancer

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