Expression Analysis Elucidates the Roles of MAML1 and Twist1 in Esophageal Squamous Cell Carcinoma Aggressiveness and Metastasis

Forghanifard, Mohammad Mahdi; Moaven, Omeed; Farshchian, Moein; Montazer, Mehdi; Raeisossadati, Reza; Abdollahi, Abbas; Moghbeli, Meysam; Nejadsattari, Taher; Parivar, Kazem; Abbaszadegan, Mohammad Reza

doi:10.1245/s10434-011-2074-8

Cited by 47 publications

(33 citation statements)

References 31 publications

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“…This study was following our recent reports about the role of Msi1 and MAML1 in ESCC progression and metastasis [20,21]. Regarding the role of Msi1 as an inhibitor for the Wnt and Notch pathways, in this report, we have assessed for the first time the probable role of Msi1 on the Notch pathway through the correlational analysis between such markers in ESCC patients.…”

Section: Discussionmentioning

confidence: 80%

“…We have assessed the correlation between the clinicopathological features of patients and MAML1 and Msi1 in separate studies, and here, we evaluated the probable correlations between these markers [20,21]. Although nine out of 51 (17.6 %) cases had Msi1/MAML1 overexpression, there was not any significant correlation between such markers (p= 0.991).…”

Section: Clinicopathological Features and Maml1/msi1 Mrna Expressionmentioning

confidence: 98%

“…Levels of Msi1/ MAML1 were assessed using the triplicate reactions of comparative relative RT-PCR (SYBR Green method, GENETBIO, Korea) in Stratagene M×3000P (Stratagene, La Jolla, CA) as described before [20,21]. Statistical analysis was performed using the SPSS 16.0 (SPSS, Chicago, IL).…”

Section: Rna Extraction Cdna Synthesis Comparative Rt-pcr and Statmentioning

confidence: 99%

“…All of the clinicopathological features (sex, age, tumor size and grade, histopathological stage, etc.) of the patients are mentioned in our recent studies (Table 1) [22,20,23,21,24].…”

Section: Study Populationmentioning

confidence: 99%

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Role of Msi1 and MAML1 in Regulation of Notch Signaling Pathway in Patients with Esophageal Squamous Cell Carcinoma

Moghbeli

Forghanifard

Sadrizadeh

et al. 2015

J Gastrointest Canc

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Section: Discussionmentioning

confidence: 80%

Section: Clinicopathological Features and Maml1/msi1 Mrna Expressionmentioning

confidence: 98%

Section: Rna Extraction Cdna Synthesis Comparative Rt-pcr and Statmentioning

confidence: 99%

“…All of the clinicopathological features (sex, age, tumor size and grade, histopathological stage, etc.) of the patients are mentioned in our recent studies (Table 1) [22,20,23,21,24].…”

Section: Study Populationmentioning

confidence: 99%

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Role of Msi1 and MAML1 in Regulation of Notch Signaling Pathway in Patients with Esophageal Squamous Cell Carcinoma

Moghbeli

Forghanifard

Sadrizadeh

et al. 2015

J Gastrointest Canc

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“…RNA extractions and cDNA syntheses were performed as described previously [23]. Quantitative real-time PCR was carried out using SYBR green PCR Master Mix (Fermentas, Lithuania), containing ROX as a reference dye on a Stratagene Mx-3000P real-time thermocycler (Stratagene, La Jolla, CA) with the primers presented in Table 1.…”

Section: Methodsmentioning

confidence: 99%

Role of SALL4 in the progression and metastasis of colorectal cancer

et al. 2013

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BackgroundHuman cancer cells resemble stem cells in expression signatures leading them to share some features, most notably, self-renewal. A complex network of transcription factors and signaling molecules are required for continuance of this trait. SALL4 is a zinc finger transcriptional activator crucial for maintenance of self-renewal in stem cells; however, its expression level has not yet been elucidated in colorectal tumor cells. To determine this level and probable clinicopathological consequences, its expression was analyzed.MethodsSALL4 expression in fresh tumoral and distant tumor-free tissues from 46 colorectal samples was compared by real-time polymerase chain reaction (PCR).ResultsGreater than a two-fold increase in SALL4 expression was detected in 87% of tumors vs. normal related tissues. SALL4 expression was significantly correlated with tumor cell metastasis to lymph nodes, especially in moderately-differentiated tumor samples (P < 0.05). Furthermore, higher levels of SALL4 mRNA expression were significantly associated with younger than older patients with tumor cells in stages I and II (P < 0.05).ConclusionsThese results indicate a relationship between SALL4 expression and tumor cell metastasis to lymph nodes and consequent advancement of tumors to advanced stages III and IV. Along with the promising evidence of its role in self-renewal in various cancers, SALL4 may have a role in progression, development and maintenance of colorectal cancers.

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TWIST1, MMP‐21, and HLAG‐1 co‐overexpression is associated with ESCC aggressiveness

Golyan

Abbaszadegan

Forghanifard

2019

J of Cellular Biochemistry

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Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive types of cancer, requiring reliable biomarkers for prognosis and therapeutic responsiveness. TWIST1, as an important factor responsible for metastasis of several cancers, is involved in tumor invasion and metastasis through indirectly regulation of MMP‐21 expression. On the other hand, NF‐ĸβ which is a regulator of HLAG‐1 has direct interaction with TWIST1 protein. In this retrospective study we investigated the clinical significance of TWIST1, MMP‐21, and HLAG‐1 expression in ESCC, and the possible correlation between these genes and progression of the disease. The gene expression analyses of TWIST1, MMP‐21, and HLA‐G1 were performed by relative comparative real‐time polymerase chain reaction in 58 ESCCs compared with corresponding margin‐normal esophageal tissues. Significant overexpression of HLAG‐1, TWIST1, and MMP‐21 messenger RNA was observed in 22.4%, 41.4%, and 60.3% of tumor samples, respectively. Concomitant overexpression of TWIST1/MMP‐21 and TWIST1/HLAG‐1 were significantly correlated to each other in various clinicopathological features, including depth of tumor invasion, stage of tumor progression, lymphatic invasion, and grade of tumor cell differentiation ( P < 0.05). The current study is the first report of coexpression of TWIST1, MMP‐21, and HLAG‐1 in ESCC. Such findings suggest an oncogenic role for concomitant expression of these genes in ESCC invasion and metastasis.

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Expression Analysis Elucidates the Roles of MAML1 and Twist1 in Esophageal Squamous Cell Carcinoma Aggressiveness and Metastasis

Cited by 47 publications

References 31 publications

Role of Msi1 and MAML1 in Regulation of Notch Signaling Pathway in Patients with Esophageal Squamous Cell Carcinoma

Role of Msi1 and MAML1 in Regulation of Notch Signaling Pathway in Patients with Esophageal Squamous Cell Carcinoma

Role of SALL4 in the progression and metastasis of colorectal cancer

TWIST1, MMP‐21, and HLAG‐1 co‐overexpression is associated with ESCC aggressiveness

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