Exposure to ZnO/TiO2 Nanoparticles Affects Health Outcomes in Cosmetics Salesclerks

Abstract

Background: Concerns about the effects of nanoparticles (NPs) on human health are being raised by researchers because the risks of nanocosmetics like sunscreen are unknown. Methods: We explored the association between urinary oxidative stress markers and exposure of cosmetics salesclerks to 20 cosmetics which might contain titanium dioxide (TiO2)/zinc oxide (ZnO) NPs. We then recruited 40 cosmetics salesclerks and 24 clothing salesclerks and categorized them based on their exposure to ZnO and TiO2 NPs. Results: Nineteen and fifteen samples met the EU definition for TiO2 and ZnO nanomaterials, respectively. Participants with a higher co-exposure index of ZnO and TiO2 NPs had a significantly higher base level of urinary 8-hydroxy-2'-deoxyguanosin (8-OHdG) concentrations than the lower co-exposure group (5.82 vs. 2.85 ng/mL, p < 0.001). After potential confounding factors had been adjusted for, the TiO2 and ZnO NP co-exposure index was significantly positively associated with the urinary 8-OHdG base concentration (β = 0.308, 95% CI = 0.106 to 0.510) and the creatinine-adjusted concentration (β = 0.486, 95% CI = 0.017 to 0.954). Conclusion: Current evidence suggests that the likelihood of harm from using sunscreens containing nanoparticles might result in higher urinary 8-OHdG. However, our limited number and types of sample cosmetics might underestimate the risk.

Combined Effects of Elevated Temperature and Crude Oil Pollution on Oxidative Stress and Apoptosis in Sea Cucumber (Apostichopus japonicus, Selenka)

“…Several recent studies have reported that oil-derived PAHs could stimulate reactive oxygen species (ROS) production during their biotransformation, resulting in an elevation of ROS levels in marine organisms [ 2 , 29 , 30 ]. Overelevation of ROS levels could further induce oxidative damage of the biomacromolecules (including DNA, proteins, and lipids) [ 31 , 32 ], which is known as the primary mechanism involved in cell damage, apoptosis, and tissue injury in marine organisms exposed to oil-derived PAHs [ 29 , 33 , 34 , 35 , 36 ]. Additionally, numerous studies have documented that elevated temperature could cause physiological (e.g., increased oxygen consumption) and histological (e.g., tissue injury) changes in marine organisms, and it has been suggested that elevated temperature could also disturb the balance between endogenous and exogenous ROS levels and thereby cause an incapacity of the antioxidant defense system [ 23 , 37 , 38 , 39 , 40 , 41 ].…”