Exposure to X-rays Causes Depression-like Behaviors in Mice via HMGB1-mediated Pyroptosis

Xu, Long; Huang, Haiqin; Liu, Tianqing; Yang, Tao; Yi, Xuan

doi:10.1016/j.neuroscience.2021.11.023

Cited by 10 publications

(6 citation statements)

References 32 publications

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“…In a depression-like behavioral model in mice, S. Kwon found 76 that acupuncture could have an antidepressant-like effect after chronic systemic inflammation/immune response induced by Bacillus Calmette Guerin Vaccine vaccination by regulating the aggravated tryptophan-kynurenine metabolic pathway and hippocampal dopaminergic nerve conduction. Other studies 77 have found that rat models of CUMS have higher expression of HMGB1, IL-1β, IL-18, IFN-γ, IL-6, and TNF-α in the hippocampus, and the relationship between HMGB1 and pyroptosis in depression has been demonstrated. Following CUMS stimulation, NLRP3 is activated and binds pro-caspase-1 via ASC oligomerization, which in turn activates caspase-1.…”

Section: Acupuncturementioning

confidence: 87%

Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism

Sun,

Cao,

Xin

et al. 2024

IJGM

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Depression is a prevalent mental disorder and has a profound impact on an individual’s psychological and physical well-being. It is characterized by a persistently depressed mood, loss of interest, energy loss, and cognitive dysfunction. In recent years, more and more people have changed to mental diseases, such as depression, anxiety, mania and so on. In the incidence of depression, covering all ages, but still mainly young and middle-aged women. Traditional treatments for depression mainly rely on medication and psychotherapy, but these methods are not effective for all patients and are often accompanied by certain side effects. Therefore, finding safe and effective alternative or adjuvant treatments has become a priority. Here we highlight the research progress of acupuncture in the treatment of depression and to explore the mechanism of acupuncture in the treatment of depression. Acupuncture treatment of depression is an ancient and effective method, the mechanism involves multiple biological pathways, for example, by regulating neurotransmitter levels, regulating the neuroendocrine axis, improving neuroplasticity, anti-inflammatory and other effects, improving emotional state and play an antidepressant role. To provide evidence to support the widespread use of acupuncture in clinical practice. We hope to provide new treatment ideas and methods for patients with depression, and even reduce the incidence of depression.

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Section: Acupuncturementioning

confidence: 87%

Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism

Sun,

Cao,

Xin

et al. 2024

IJGM

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“…Radiation-induced brain injury is a common complication of brain irradiation, which may cause cognitive dysfunction and neuroinflammation. Anxious-depression-like behaviors are among the side effects of brain radiotherapy ( Xu et al . 2022 ).…”

Section: Radiation Toxicity and The Role Of Microbiotamentioning

confidence: 99%

Radiation injury and gut microbiota-based treatment

et al. 2023

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The exposure to either medical sources or accidental radiation can cause varying degrees of radiation injury (RI). RI is a common disease involving multiple human body parts and•organs, yet effective treatments are currently limited. Accumulating evidence suggests gut microbiota are closely associated with the development and prevention of various RI. This article summarizes ten common types of RI and their possible mechanisms. It also highlights the changes and potential microbiota-based treatments for RI, including probiotics, metabolites, and microbiota transplantation. Additionally, a 5P-Framework is proposed to provide a comprehensive strategy for managing RI.

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“…In a dose‐dependent manner, a separate study demonstrated that x‐ray stimulation induced the production of ROS and overexpression of HMGB1 in mouse neurons. This, in turn, mediated microglial pyroptosis through the NLRP3/ASC/caspase‐1 pathway 71 . AIM2, a well‐known sensor of inflammasomes involved in the pyroptosis pathway, has been observed to detect DNA damage caused by nuclear ionizing radiation and chemotherapeutic drugs, leading to inflammasome activation and cell death 69 .…”

Section: Induction Of Pyroptosis In Cancer Therapymentioning

confidence: 99%

Pyroptosis in glioma: Current management and future application

Guo,

Su,

Wei

et al. 2023

Immunological Reviews

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SummaryGlioma, the predominant form of central nervous system (CNS) malignancies, presents a significant challenge due to its high prevalence and low 5‐year survival rate. The efficacy of current treatment methods is limited by the presence of the blood–brain barrier, the immunosuppressive microenvironment, and other factors. Immunotherapy has emerged as a promising approach, as it can overcome the blood–brain barrier. A tumor's immune privilege, which is induced by an immunosuppressive environment, constricts immunotherapy's clinical impact in glioma. Pyroptosis, a programmed cell death mechanism facilitated by gasdermins, plays a significant role in the management of glioma. Its ability to initiate and regulate tumor occurrence, progression, and metastasis is well‐established. However, it is crucial to note that uncontrolled or excessive cell death can result in tissue damage, acute inflammation, and cytokine release syndrome, thereby potentially promoting tumor advancement or recurrence. This paper aims to elucidate the molecular pathways involved in pyroptosis and subsequently discuss its induction in cancer therapy. In addition, the current treatment methods of glioma and the use of pyroptosis in these treatments are introduced. It is hoped to provide more ideas for the treatment of glioma.

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Exposure to X-rays Causes Depression-like Behaviors in Mice via HMGB1-mediated Pyroptosis

Cited by 10 publications

References 32 publications

Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism

Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism

Radiation injury and gut microbiota-based treatment

Pyroptosis in glioma: Current management and future application

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