Exposure to wood smoke, HPV infection, and genetic susceptibility for cervical neoplasia among women in Colombia

Sierra‐Torres, Carlos H.; Arboleda‐Moreno, Yexania Y.; Orejuela‐Aristizabal, Leonora

doi:10.1002/em.20228

Cited by 22 publications

(13 citation statements)

References 43 publications

(62 reference statements)

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“…Among them, GSTM1 and GSTT1 should be pointed out because a polymorphic deletion of these genes may influence the enzyme activity, and eventually increased vulnerability to genotoxic damage [60], [61]. Based on these backgrounds, the association has been intensively investigated between GSTM1 and GSTT1 polymorphisms and risk of cervical neoplasia [25]–[49]. Unfortunately, most of the studies have only a few hundred of participants, even less, which is too small to evaluate the overall effects precisely.…”

Section: Discussionmentioning

confidence: 99%

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Null Genotypes of GSTM1 and GSTT1 Contribute to Risk of Cervical Neoplasia: An Evidence-Based Meta-Analysis

Gao

Pan

et al. 2011

PLoS ONE

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Background and ObjectivesGlutathione S-transferases (GSTs) are multifunctional enzymes that play a key role in the detoxification of varieties of both endogenous products of oxidative stress and exogenous carcinogens.MethodsIn this meta-analysis, twenty-five studies were identified by searching PubMed, EMBASE, ISI Web of Science and CBM databases: 23 evaluated GSTM1 and 19 evaluated GSTT1. Crude odds ratios with corresponding 95% confidence intervals were used to estimate the association between GSTM1 and GSTT1 polymorphisms and risk of cervical neoplasia. Subgroup analyses were conducted by pathological history, ethnicity, source of DNA for genotyping, quality score, and matching variable.ResultsThe null genotypes of GSTM1 and GSTT1 polymorphisms were associated with a significantly increased risk of cervical neoplasia (for GSTM1: OR = 1.40; 95%CI, 1.19–1.65; for GSTT1: OR = 1.30; 95%CI, 1.05–1.62, respectively). Subgroup analyses showed that the null genotype of GSTM1 increased the risk of cervical neoplasia in Asians, studies with DNA isolation from white blood cells and tissue samples, both high and low quality studies, and matched studies. In GSTM1-GSTT1 interaction analysis, individuals with dual null genotype were associated with a significantly increased risk of cervical neoplasia (OR = 1.72; 95%CI, 1.18–2.51).ConclusionThese findings indicate that GSTM1 and GSTT1 polymorphisms, particularly GSTM1-GSTT1 interaction, may play critical roles in the development of cervical neoplasia. A conservative manner should be adopted to interpret these results because of obvious heterogeneity between-study, unadjusted data, and relatively small sample size in this meta-analysis. Well designed studies with larger sample size are of great value to confirm these results.

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Section: Discussionmentioning

confidence: 99%

“…Subsequently, a large number of epidemiological studies have been addressed to evaluate the association between GSTM1 and GSTT1 homozygous deletion polymorphisms and risk of cervical neoplasia in diverse ethnicities [25]–[49]. However, this issue remains controversial because of inconsistent results among different studies.…”

Section: Introductionmentioning

confidence: 99%

Null Genotypes of GSTM1 and GSTT1 Contribute to Risk of Cervical Neoplasia: An Evidence-Based Meta-Analysis

Gao

Pan

et al. 2011

PLoS ONE

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“…Fifty-seven were excluded for various reasons (26 studies did not involve CC, 18did not involve polymorphisms, 5 did not include controls, 4 were conducted on overlapping populations, and 4 were review articles). Finally, 23 case-control studies [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40] were included in the GSTM1 genotype meta-analysis (2343 cases and 2662 controls). The meta-analysis included studies from China, India, Japan, Korea, Italy, USA, Greece, Brazil, Turkey, and Thailand.…”

Section: Resultsmentioning

confidence: 99%

Glutathione S-Transferase Polymorphism Interactions with Smoking Status and HPV Infection in Cervical Cancer Risk: An Evidence-Based Meta-Analysis

Zhen

Bian

2013

PLoS ONE

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BackgroundHuman papillomavirus (HPV) infection is considered the major cause of cervical cancer (CC), but a number of infected women do not develop invasive lesions, suggesting the role of genetic susceptibility and environmental co-factors for cancer outbreak. Glutathione S- transferases (GSTs) are multifunctional enzymes that play a key role in the detoxification of varieties of both endogenous products of oxidative stress and exogenous carcinogens.MethodsMEDLINE, EMBASE, and Cochrane databases were searched. All studies evaluating the association between GSTM1 polymorphisms and cervical cancer were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using fixed-or random-effects model.ResultsA total of 23 case-control studies were included in the meta-analysis. The overall result showed that the association between GSTM1 null genotype and risk for cervical cancer was statistically significant (OR = 1.56; 95%CI, 1.39–1.75). Subgroup analyses were performed based on ethnicity, smoking and HPV infection. Our results showed that smokers with null GSTM1 genotype had higher risk of cervical cancer (OR = 2.27, 95%CI, 1.46–3.54). For the ethnicity stratification, significant increased risk of null GSTM1 genotype was found in Chinese and Indian population, but no increased risk in other population was found.Conclusionsthis meta-analysis provided strong evidence that the GSTM1 genotype is associated with CC development, especially in Chinese and Indian populations. Smoking and HPV infection modified the association between the null GSTM1 genotype and CC.

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“…With our search criterion, 123 individual records were found, but only 31 full-text articles were preliminarily identified for further detailed evaluation. According to the exclusion criteria, 15 articles were excluded including 5 articles containing overlapping population [7][8][9][10][11], 8 precancerous lesions included in the cases [12][13][14][15][16][17][18][19], 2 without sufficient data [20][21]. At last, data were available from 16 individual case-control studies [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37], Table 1 presented characteristics of these 16 case-control studies (a total of 1,627 CC cases and 2,161 controls).…”

Section: Resultsmentioning

confidence: 99%

Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

Wang

Wang²,

Jx³

et al. 2011

neo

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There were some studies on the associations between Glutathione S-transferase M1 (GSTM1) and Glutathione S-transferase T1 (GSTT1) polymorphisms and cervical cancer (CC) risk, but the results were inconsistent. Thus, a meta-analysis was performed.The electronic databases PubMed, Science Direct, CBM, and CNKI were searched for possible studies. Finally, 16 studies (1,627 cases and 2,161 controls) were included. For the GSTM1 and GSTT1 polymorphisms, the unadjusted odds ratios (OR) and 95% confidence intervals (95% CI) from each study were used to estimate summary OR. Subgroup analyses by ethnicity and histological type of CC were also performed.For the GSTM1 polymorphism, the null genotype of GSTM1 was associated with an increased CC risk in total population (OR=1.32, 95% CI=1.06-1.66). Similar association was found in Asians (OR=1.47, 95% CI=1.11-1.94), but not in Caucasians (OR=0.96, 95% CI=0.73-1.27). For the GSTT1 polymorphism, the null genotype of GSTT1 was not statistically significantly associated with CC risk in total population (OR=1.36, 95% CI=0.97-1.90). This result was also found in Asians (OR=1.27, 95% CI=0.87-1.85) and Caucasians (OR=1.09, 95% CI= 0.66-1.79), but not in Latinos (OR=4.58, 95% CI= 2.04-10.28). For the GSTM1/GSTT1 interaction analysis, the dual null genotypes of GSTM1/GSTT1 were significantly associated with increased CC risk in total population (OR=1.77, 95% CI= 1.14-2.75), and all the six studies were from Asia. For subgroup analyses by histological type of CC, the three aspects of the analyses above were all not significantly associated with CC risk in squamous cell carcinoma and adenocarcinoma, respectively.The null genotype of GSTM1 and the dual null genotypes of GSTM1/GSTT1 were risk factors in CC, and the null genotype of GSTT1 was not associated with CC risk.

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Exposure to wood smoke, HPV infection, and genetic susceptibility for cervical neoplasia among women in Colombia

Cited by 22 publications

References 43 publications

Null Genotypes of GSTM1 and GSTT1 Contribute to Risk of Cervical Neoplasia: An Evidence-Based Meta-Analysis

Null Genotypes of GSTM1 and GSTT1 Contribute to Risk of Cervical Neoplasia: An Evidence-Based Meta-Analysis

Glutathione S-Transferase Polymorphism Interactions with Smoking Status and HPV Infection in Cervical Cancer Risk: An Evidence-Based Meta-Analysis

Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

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