Exposure to volatile organic compounds and polycyclic aromatic hydrocarbons is associated with the risk of non-alcoholic fatty liver disease in Korean adolescents: Korea National Environmental Health Survey (KoNEHS) 2015–2017

Choi, Yun-Hee; Lee, Ju‐Yeon; Moon, Kyong Whan

doi:10.1016/j.ecoenv.2023.114508

Cited by 11 publications

(5 citation statements)

References 43 publications

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“…Cardiovascular disease [81], metabolic syndrome [82], NAFLD [83], and kidney disease [66] Air pollution PM 10 , PM 2.5…”

Section: Pfoa Pfosmentioning

confidence: 99%

“…PAHs emerge during the refining of coal, crude oil, and natural gas [102]. Human studies have found a relationship between PAH exposure and cardiovascular disease [81], metabolic syndrome [82], NAFLD [83], and kidney disease [67,103]. As PAHs can pass through the placental barrier, studies have shown that exposure to PAHs during pregnancy can result in developmental toxicity [104].…”

Section: Polycyclic Aromatic Hydrocarbonmentioning

confidence: 99%

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The Impact of the Aryl Hydrocarbon Receptor on Antenatal Chemical Exposure-Induced Cardiovascular–Kidney–Metabolic Programming

Tain,

Hsu

2024

IJMS

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Early life exposure lays the groundwork for the risk of developing cardiovascular–kidney–metabolic (CKM) syndrome in adulthood. Various environmental chemicals to which pregnant mothers are commonly exposed can disrupt fetal programming, leading to a wide range of CKM phenotypes. The aryl hydrocarbon receptor (AHR) has a key role as a ligand-activated transcription factor in sensing these environmental chemicals. Activating AHR through exposure to environmental chemicals has been documented for its adverse impacts on cardiovascular diseases, hypertension, diabetes, obesity, kidney disease, and non-alcoholic fatty liver disease, as evidenced by both epidemiological and animal studies. In this review, we compile current human evidence and findings from animal models that support the connection between antenatal chemical exposures and CKM programming, focusing particularly on AHR signaling. Additionally, we explore potential AHR modulators aimed at preventing CKM syndrome. As the pioneering review to present evidence advocating for the avoidance of toxic chemical exposure during pregnancy and deepening our understanding of AHR signaling, this has the potential to mitigate the global burden of CKM syndrome in the future.

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“…Cardiovascular disease [81], metabolic syndrome [82], NAFLD [83], and kidney disease [66] Air pollution PM 10 , PM 2.5…”

Section: Pfoa Pfosmentioning

confidence: 99%

Section: Polycyclic Aromatic Hydrocarbonmentioning

confidence: 99%

The Impact of the Aryl Hydrocarbon Receptor on Antenatal Chemical Exposure-Induced Cardiovascular–Kidney–Metabolic Programming

Tain,

Hsu

2024

IJMS

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“…Recently, it was found that PAH and VOC increased non-alcoholic fatty liver disease (NAFLD) among South Korean adolescents. A total of 798 adolescent participants were tested, 381 male and 417 female, and the results showed that 73 (9.1%) of the participants had been diagnosed with NAFLD [99].…”

Section: Other Reported Diseasesmentioning

confidence: 99%

Effect of Persistent Organic Pollutants on Human Health in South Korea: A Review of the Reported Diseases

Rokni,

Rezaei,

Rafieizonooz

et al. 2023

Sustainability

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Persistent organic pollutants (POPs) usually originate from human activities and have been released into the environment for several decades. They are highly resistant to natural decomposition and can accumulate in an organism’s tissues and in all environmental components. Due to their unique characteristics, they have an ability to bio-magnify and bio-accumulate in animals, through the food chain and via inhalation, severely endangering the health of people. As reported, the exposure of humans to POPs causes various health problems such as cancers, diabetes, birth defects, endocrine disruption, cardiovascular diseases and dysfunctional immune and reproductive systems. The residents of South Korea are likely to face a high risk of diseases because of the existence of POPs in the environment. For instance, South Korea’s atmosphere has been reported as a hotspot for POP pollution. Besides, South Koreans’ high amount of seafood consumption is considered another source of POPs. Therefore, this article reviews the status of POP contamination in food and the health impact of POPs in South Korea. Based on the findings, the most-reported diseases were obesity and diabetes, which positively correlated to age, food habits, body index, and level of exposure to POPs. In addition, cancer and metabolic diseases are at an alarming level. Therefore, the public health impacts of POPs need continuous assessment in South Korea over the next decade.

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“…While the carcinogenic effects of PAH make them a chemical of concern, there is limited information on the toxic effects of PAH on the liver, which is a primary site of PAH metabolization ( Zhou et al, 2024 ). Current studies only report associations of PAH exposure with impaired liver function ( Xu et al, 2021 ; Choi et al, 2023 ; Zhou et al, 2024 ) and lack information on the molecular mechanisms underlying specific hepatotoxic endpoints.…”

Section: Introductionmentioning

confidence: 99%

Exposure to PFAS chemicals induces sex-dependent alterations in key rate-limiting steps of lipid metabolism in liver steatosis

Hari,

AbdulHameed,

Balik-Meisner

et al. 2024

Front. Toxicol.

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Toxicants with the potential to bioaccumulate in humans and animals have long been a cause for concern, particularly due to their association with multiple diseases and organ injuries. Per- and polyfluoro alkyl substances (PFAS) and polycyclic aromatic hydrocarbons (PAH) are two such classes of chemicals that bioaccumulate and have been associated with steatosis in the liver. Although PFAS and PAH are classified as chemicals of concern, their molecular mechanisms of toxicity remain to be explored in detail. In this study, we aimed to identify potential mechanisms by which an acute exposure to PFAS and PAH chemicals can induce lipid accumulation and whether the responses depend on chemical class, dose, and sex. To this end, we analyzed mechanisms beginning with the binding of the chemical to a molecular initiating event (MIE) and the consequent transcriptomic alterations. We collated potential MIEs using predictions from our previously developed ToxProfiler tool and from published steatosis adverse outcome pathways. Most of the MIEs are transcription factors, and we collected their target genes by mining the TRRUST database. To analyze the effects of PFAS and PAH on the steatosis mechanisms, we performed a computational MIE-target gene analysis on high-throughput transcriptomic measurements of liver tissue from male and female rats exposed to either a PFAS or PAH. The results showed peroxisome proliferator-activated receptor (PPAR)-α targets to be the most dysregulated, with most of the genes being upregulated. Furthermore, PFAS exposure disrupted several lipid metabolism genes, including upregulation of fatty acid oxidation genes (Acadm, Acox1, Cpt2, Cyp4a1-3) and downregulation of lipid transport genes (Apoa1, Apoa5, Pltp). We also identified multiple genes with sex-specific behavior. Notably, the rate-limiting genes of gluconeogenesis (Pck1) and bile acid synthesis (Cyp7a1) were specifically downregulated in male rats compared to female rats, while the rate-limiting gene of lipid synthesis (Scd) showed a PFAS-specific upregulation. The results suggest that the PPAR signaling pathway plays a major role in PFAS-induced lipid accumulation in rats. Together, these results show that PFAS exposure induces a sex-specific multi-factorial mechanism involving rate-limiting genes of gluconeogenesis and bile acid synthesis that could lead to activation of an adverse outcome pathway for steatosis.

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Exposure to volatile organic compounds and polycyclic aromatic hydrocarbons is associated with the risk of non-alcoholic fatty liver disease in Korean adolescents: Korea National Environmental Health Survey (KoNEHS) 2015–2017

Cited by 11 publications

References 43 publications

The Impact of the Aryl Hydrocarbon Receptor on Antenatal Chemical Exposure-Induced Cardiovascular–Kidney–Metabolic Programming

The Impact of the Aryl Hydrocarbon Receptor on Antenatal Chemical Exposure-Induced Cardiovascular–Kidney–Metabolic Programming

Effect of Persistent Organic Pollutants on Human Health in South Korea: A Review of the Reported Diseases

Exposure to PFAS chemicals induces sex-dependent alterations in key rate-limiting steps of lipid metabolism in liver steatosis

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