Exposure to transportation noise and risk for cardiovascular disease in a nationwide cohort study from Denmark

Thacher, Jesse D.; Poulsen, Aslak Harbo; Raaschou‐Nielsen, Ole; Hvidtfeldt, Ulla Arthur; Brandt, Jørgen; Christensen, J. H.; Khan, Jibran; Levin, Gregor; Münzel, Thomas; Sørensen, Mette

doi:10.1016/j.envres.2022.113106

Cited by 39 publications

(28 citation statements)

References 47 publications

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“…Noteworthy, an excess risk of hospitalization for AMI was shown among women in class 4 only in the night period, and a risk trend both for daytime and nighttime noise. In the literature, some findings on the associations between AMI and road traffic noise can be found in the general population considering both men and women, adjusting for air pollution, socioeconomic status, and factors related to lifestyle [ 28 , 42 , 50 , 53 ], confirming that road traffic noise and air pollution are correlated. Other studies revealed an increase in AMI risk only in men [ 34 , 54 , 55 ], contrary to what we observed only among women.…”

Section: Discussionmentioning

confidence: 92%

“…The results on the association between road traffic noise and IHD are inconsistent. Some studies reported positive associations [ 28 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ], whereas in other studies no associations were found [ 31 , 34 , 45 , 46 , 47 , 48 , 49 , 50 ]. Our findings of increasing mortality trends close to statistical significance for IHD among women exposed to both night and daytime noise are in line with the study of Piko et al, who reported an increased risk of IHD in women exposed to road traffic [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

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Risk Associations between Vehicular Traffic Noise Exposure and Cardiovascular Diseases: A Residential Retrospective Cohort Study

Bustaffa

Curzio

Donzelli

et al. 2022

IJERPH

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Environmental noise can induce detrimental health effects such as cardiovascular disease (CVD). The relationship between vehicular traffic noise pollution and CVD was investigated through a retrospective residential cohort study in the city of Pisa. Four exposure classes were defined for noise pollution, using noise propagation maps. The association between noise exposures and cause-specific mortality or hospitalization of the subjects of the cohort was calculated using the hazard ratio (HR) for night and day through a multiple time-dependent and sex-specific Cox regression adjusting for age, the socio-economic deprivation index, and traffic air pollution. Mortality excess for CVD and risk trends for a 1 decibel noise increment were observed among the most exposed women (mortality: HRnightclass4 1.15 (1.03–1.28); Trendnight 1.007 (1.002–1.012); HRdayclass4 1.14 (1.02–1.27); Trendday 1.008 (1.003–1.013)), particularly for ischaemic disease (mortality: Trendnight 1.008 (0.999–1.017); Trendday 1.009 (0.999–1.018)) and cerebrovascular disease (mortality: HRnightclass3 1.23 (1.02–1.48), HRdayclass3 1.24 (1.03–1.49)). Hospitalization analyses confirm mortality results. A decreased risk for hospitalization was also observed among the most exposed men (HRdayclass4 0.94 (0.88–1.01), particularly for ischaemic disease (HRnightclass4 0.90 (0.80–1.02); HRdayclass4 0.86 (0.77–0.97)) and cerebrovascular disease (HRnightclass4 0.89 (0.78–1.01)). Authors recommend the adoption of prevention measures aimed at mitigating noise and the activation of a monitoring of the risk profile in the Pisa population updating both the residential cohort and health data.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Risk Associations between Vehicular Traffic Noise Exposure and Cardiovascular Diseases: A Residential Retrospective Cohort Study

Bustaffa

Curzio

Donzelli

et al. 2022

IJERPH

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“…There is high scientific plausibility to conclude that train noise exposure increases cardiovascular risk as suggested by recent large-scale epidemiological studies. In a nationwide cohort study from Denmark from Thacher et al, residential railway noise exposure at the least exposed façade was associated with a 28% higher risk of incident heart failure (hazard ratio (HR) 1.28, 95% CI 1.004–1.053) [ 22 ]. Within the same cohort, the authors further found suggestive evidence of an association between railway noise exposure and incident atrial fibrillation (incidence rate ratio (IRR) 1.017, 95 CI 1.007–1.026 for the most and IRR 1.035, 95% CI 1.021–1.050 for the least exposed façade), which was sensitive to further adjustment for air pollution (mean railway noise levels at the least exposed façade were ~46 dB L den and at the most exposed façade were ~53 dB L den [ 23 ]).…”

Section: Discussionmentioning

confidence: 99%

Acute Exposure to Simulated Nocturnal Train Noise Leads to Impaired Sleep Quality and Endothelial Dysfunction in Young Healthy Men and Women: A Sex-Specific Analysis

Hahad

Herzog

Röösli

et al. 2022

IJERPH

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A series of human field studies demonstrated that simulated nocturnal traffic noise exposure impaired sleep quality and endothelial function, which could be significantly improved after intake of vitamin C in case of endothelial function. However, it remains unclear whether these changes follow a sex-specific pattern. Thus, we aimed to analyze the effect of simulated nocturnal train noise exposure on sleep quality, endothelial function and its associated changes after vitamin C intake, and other hemodynamic and biochemical parameters in young healthy men and women. We used data from a randomized crossover study, wherein 70 healthy volunteers (50% women) were each exposed to one control pattern (regular background noise) and two different train noise scenarios (30 or 60 train noise events per night, with average sound pressure levels of 52 and 54 dB(A), respectively, and peak sound level of 73–75 dB(A)) in their homes for three nights. After each night, participants visited the study center for the measurement of endothelial function as well as other hemodynamic and biochemical parameters. Sleep quality measured via self-report was significantly impaired after noise 30 and noise 60 nights in both men and women (p < 0.001 vs. control). Likewise, endothelial function measured by flow-mediated dilation (FMD) was significantly impaired after noise 30 and noise 60 nights in both men and women (p < 0.001 vs. control). While in women, vitamin C intake significantly improved FMD after both noise 30 and noise 60 study nights compared to control nights, no significant changes were observed in men. Exposure to simulated nocturnal train noise impairs sleep quality and endothelial function in both men and women, whereas a significant improvement of endothelial function after noise exposure and vitamin C intake could only be observed in women. These findings suggest for the first time that in men other mechanisms such as oxidative stress causing endothelial dysfunction may come into play.

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“…Herein it is important to acknowledge that the evidence on the relationship between noise exposure levels and risk of cardiovascular disease is much more conclusive. In support of this, recent high-quality studies rigorously demonstrated that chronic exposure to higher traffic noise levels can increase the risk of cardiovascular disease including cardiovascular death (27), hypertension (28), atrial fibrillation (29), ischemic heart disease, myocardial infarction, and heart failure (30). Importantly, a recent meta-analysis including five studies and 3,866,986 participants found a significant association between noise exposure and the risk of atrial fibrillation (RR 1.05, 95% CI 1.02-1.09) (31).…”

Section: Noise Annoyance (Subjective Dimension) Vs Noise Exposure Lev...mentioning

confidence: 94%

Noise annoyance and risk of prevalent and incident atrial fibrillation–A sex-specific analysis

Hahad

Beutel²,

Gilan³

et al. 2022

Front. Public Health

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BackgroundWhile chronic exposure to high levels of noise was demonstrated to increase the risk of various cardiovascular diseases, the association between noise annoyance and risk of cardiovascular disease remains still inconsistent. Recently, we showed that noise annoyance is associated with prevalent atrial fibrillation in the general population. However, the association between noise annoyance and risk of incident atrial fibrillation as well as potential sex-differences remain still elusive.Methods and results15,010 subjects from a German population-based cohort were examined at baseline (2007 to 2012) and follow-up five years later (2012 to 2017) to investigative the association between noise annoyance due to multiple sources and prevalent and incident atrial fibrillation. After multivariable adjustment, the results from logistic regression analyses revealed overall consistent and positive associations between noise annoyance and prevalent and incident atrial fibrillation in men, whereas this association was weaker in women, in particular with respect to incident atrial fibrillation. For instance, industrial noise annoyance was associated with 21% (95% confidence interval (CI) 9–34%) and 18% (8–29%) higher odds of prevalent atrial fibrillation in men and women, respectively. In prospective analysis, this association remained stable in men (odds ratio (OR) 1.25, 1.07–1.44), while in women no association was observed (OR 1.03, 0.89–1.18).ConclusionsThe findings suggest that noise annoyance can increase the risk of incident atrial fibrillation in a large population-based cohort and that men may be more sensitive to the adverse effects of noise annoyance with regard to the risk of atrial fibrillation.

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Exposure to transportation noise and risk for cardiovascular disease in a nationwide cohort study from Denmark

Cited by 39 publications

References 47 publications

Risk Associations between Vehicular Traffic Noise Exposure and Cardiovascular Diseases: A Residential Retrospective Cohort Study

Risk Associations between Vehicular Traffic Noise Exposure and Cardiovascular Diseases: A Residential Retrospective Cohort Study

Acute Exposure to Simulated Nocturnal Train Noise Leads to Impaired Sleep Quality and Endothelial Dysfunction in Young Healthy Men and Women: A Sex-Specific Analysis

Noise annoyance and risk of prevalent and incident atrial fibrillation–A sex-specific analysis

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