Noise annoyance and risk of prevalent and incident atrial fibrillation–A sex-specific analysis

Hahad, Omar; Beutel, Manfred E.; Gilan, Donya; Chalabi, Julian; Schuster, Alexander; Gianicolo, Emilio; Lackner, Karl J.; Lieb, Klaus; Galle, Peter R.; Wild, Philipp S.; Daiber, Andreas; Münzel, Thomas

doi:10.3389/fpubh.2022.1061328

Cited by 6 publications

(7 citation statements)

References 42 publications

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“…This, in turn, generates the development and acceleration of cardiovascular risk factors such as arterial hypertension, arrhythmia, dyslipidemia, increased blood viscosity and blood glucose, and activation of blood clotting factors, finally leading to manifest cardiovascular disease over time. In line, we have recently shown that noise annoyance due to different sources is associated with a higher risk of prevalent and incident atrial fibrillation in the Gutenberg Health Study (GHS), including 15,010 participants [ 3 – 5 ]. A further study based on data from the GHS also revealed that noise annoyance due to different sources was associated with increased midregional pro-atrial natriuretic peptide levels, a marker that is associated with endothelial function, which in turn was predictive of incident atrial fibrillation and cardiovascular disease as well as all-cause mortality [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Acute exposure to simulated nocturnal traffic noise and cardiovascular complications and sleep disturbance—results from a pooled analysis of human field studies

Hahad,

Schmidt,

Hübner

et al. 2023

Clin Res Cardiol

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Objectives A series of human field studies demonstrated that acute exposure to simulated nocturnal traffic noise is associated with cardiovascular complications and sleep disturbance, including endothelial dysfunction, increased blood pressure, and impaired sleep quality. A pooled analysis of these results remains to be established and is of tremendous interest to consolidate scientific knowledge. Methods We analyzed data from four randomized crossover studies (published between 2013 to 2021 and conducted at the University Medical Center Mainz, Germany). A total of 275 subjects (40.4% women, mean age 43.03 years) were each exposed to one control scenario (regular background noise) and at least to one traffic noise scenario (60 aircraft or train noise events) in their homes during nighttime. After each night, the subjects visited the study center for comprehensive cardiovascular function assessment, including the measurement of endothelial function and hemodynamic and biochemical parameters, as well as sleep-related variables. Results The pooled analysis revealed a significantly impaired endothelial function when comparing the two different noise sequences (0–60 vs. 60–0 simulated noise events, mean difference in flow-mediated dilation −2.00%, 95% CI −2.32; −1.68, p < 0.0001). In concordance, mean arterial pressure was significantly increased after traffic noise exposure (mean difference 2.50 mmHg, 95% CI 0.54; 4.45, p = 0.013). Self-reported sleep quality, the restfulness of sleep, and feeling in the morning were significantly impaired after traffic noise exposure (all p < 0.0001). Discussion Acute exposure to simulated nocturnal traffic noise is associated with endothelial dysfunction, increased mean arterial pressure, and sleep disturbance.

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Section: Discussionmentioning

confidence: 99%

Acute exposure to simulated nocturnal traffic noise and cardiovascular complications and sleep disturbance—results from a pooled analysis of human field studies

Hahad,

Schmidt,

Hübner

et al. 2023

Clin Res Cardiol

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“…Noise can also increase the risk of mental disorders such as depression, anxiety disorders, psychoses and suicide. 95 These place effects and other different potential causal factors need to be considered in future studies. Proximity to roads, for example, is also used as a proxy for air pollution exposure and noise.…”

Section: Methodological Issues In Air Pollution and Mental Health Res...mentioning

confidence: 99%

Air quality and mental health: evidence, challenges and future directions

et al. 2023

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Background Poor air quality is associated with poor health. Little attention is given to the complex array of environmental exposures and air pollutants that affect mental health during the life course. Aims We gather interdisciplinary expertise and knowledge across the air pollution and mental health fields. We seek to propose future research priorities and how to address them. Method Through a rapid narrative review, we summarise the key scientific findings, knowledge gaps and methodological challenges. Results There is emerging evidence of associations between poor air quality, both indoors and outdoors, and poor mental health more generally, as well as specific mental disorders. Furthermore, pre-existing long-term conditions appear to deteriorate, requiring more healthcare. Evidence of critical periods for exposure among children and adolescents highlights the need for more longitudinal data as the basis of early preventive actions and policies. Particulate matter, including bioaerosols, are implicated, but form part of a complex exposome influenced by geography, deprivation, socioeconomic conditions and biological and individual vulnerabilities. Critical knowledge gaps need to be addressed to design interventions for mitigation and prevention, reflecting ever-changing sources of air pollution. The evidence base can inform and motivate multi-sector and interdisciplinary efforts of researchers, practitioners, policy makers, industry, community groups and campaigners to take informed action. Conclusions There are knowledge gaps and a need for more research, for example, around bioaerosols exposure, indoor and outdoor pollution, urban design and impact on mental health over the life course.

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“…The analysis revealed consistent and positive associations between noise annoyance and prevalent incident AF in men, while the association was weaker in women, particularly for incident AF. 53 A Danish study involving female nurses investigated the relationship between road traffic noise, air pollution, and AF incidence. The findings indicated that long-term exposure to higher levels of road traffic noise was associated with an increased risk of AF.…”

Section: Noise Pollutionmentioning

confidence: 99%

Environmental Exposome and Atrial Fibrillation: Emerging Evidence and Future Directions

Wass,

Hahad,

Asad

et al. 2024

Circulation Research

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There has been increased awareness of the linkage between environmental exposures and cardiovascular health and disease. Atrial fibrillation is the most common sustained cardiac arrhythmia, affecting millions of people worldwide and contributing to substantial morbidity and mortality. Although numerous studies have explored the role of genetic and lifestyle factors in the development and progression of atrial fibrillation, the potential impact of environmental determinants on this prevalent condition has received comparatively less attention. This review aims to provide a comprehensive overview of the current evidence on environmental determinants of atrial fibrillation, encompassing factors such as air pollution, temperature, humidity, and other meteorologic conditions, noise pollution, greenspace, and the social environment. We discuss the existing evidence from epidemiological and mechanistic studies, critically evaluating the strengths and limitations of these investigations and the potential underlying biological mechanisms through which environmental exposures may affect atrial fibrillation risk. Furthermore, we address the potential implications of these findings for public health and clinical practice and identify knowledge gaps and future research directions in this emerging field.

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Noise annoyance and risk of prevalent and incident atrial fibrillation–A sex-specific analysis

Cited by 6 publications

References 42 publications

Acute exposure to simulated nocturnal traffic noise and cardiovascular complications and sleep disturbance—results from a pooled analysis of human field studies

Acute exposure to simulated nocturnal traffic noise and cardiovascular complications and sleep disturbance—results from a pooled analysis of human field studies

Air quality and mental health: evidence, challenges and future directions

Environmental Exposome and Atrial Fibrillation: Emerging Evidence and Future Directions

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