Exposure to traffic pollutants and effects on 17-β-estradiol (E2) in female workers

Tomei, Gianfranco; Ciarrocca, Manuela; Fortunato, Bruna Rita; Capozzella, Assunta; Rosati, Maria Valeria; Cerratti, D.; Tomao, Enrico; Anzelmo, Vincenza; Monti, Carlo; Tomei, Francesco

doi:10.1007/s00420-006-0105-8

Cited by 17 publications

(7 citation statements)

References 47 publications

(46 reference statements)

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“…They found an average level of estradiol that was statistically significantly lower in the exposed group in the follicular phase and luteal phase of the cycle, but not in the ovulatory phase. Although no statistically significant difference between the two groups was noted in terms of disruption of the menstrual cycle, the authors suggest that these hormonal changes could alter ovulation in exposed women [74].…”

Section: In Humansmentioning

confidence: 80%

Does air pollution play a role in infertility?: a systematic review

et al. 2017

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Background: Air pollution is involved in many pathologies. These pollutants act through several mechanisms that can affect numerous physiological functions, including reproduction: as endocrine disruptors or reactive oxygen species inducers, and through the formation of DNA adducts and/or epigenetic modifications. We conducted a systematic review of the published literature on the impact of air pollution on reproductive function. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included (1) ovary or follicle or oocyte or testis or testicular or sperm or spermatozoa or fertility or infertility and (2) air quality or O 3 or NO 2 or PM2.5 or diesel or SO 2 or traffic or PM10 or air pollution or air pollutants. The literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We have included the human and animal studies corresponding to the search terms and published in English. We have excluded articles whose results did not concern fertility or gamete function and those focused on cancer or allergy. We have also excluded genetic, auto-immune or iatrogenic causes of reduced reproduction function from our analysis. Finally, we have excluded animal data that does not concern mammals and studies based on results from in vitro culture. Data have been grouped according to the studied pollutants in order to synthetize their impact on fertility and the molecular pathways involved.

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Section: In Humansmentioning

confidence: 80%

Does air pollution play a role in infertility?: a systematic review

et al. 2017

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“…In this context, few studies have attempted to explain how PM exposure can trigger female infertility and increase the rate of pregnancy loss 9 , 10 . Furthermore, the precise mechanisms underlying PM exposure-related female infertility are still poorly understood, probably due to the multiplicity of factors affecting female reproductive function and fertility 11 – 13 .…”

Section: Introductionmentioning

confidence: 99%

The impact of fine particulate matter (PM) on various beneficial functions of human endometrial stem cells through its key regulator SERPINB2

Park

Kim

et al. 2021

Exp Mol Med

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Fine particulate matter (PM) has a small diameter but a large surface area; thus, it may have broad toxic effects that subsequently damage many tissues of the human body. Interestingly, many studies have suggested that the recent decline in female fertility could be associated with increased PM exposure. However, the precise mechanisms underlying the negative effects of PM exposure on female fertility are still a matter of debate. A previous study demonstrated that resident stem cell deficiency limits the cyclic regenerative capacity of the endometrium and subsequently increases the pregnancy failure rate. Therefore, we hypothesized that PM exposure induces endometrial tissue damage and subsequently reduces the pregnancy rate by inhibiting various beneficial functions of local endometrial stem cells. Consistent with our hypothesis, we showed for the first time that PM exposure significantly inhibits various beneficial functions of endometrial stem cells, such as their self-renewal, transdifferentiation, and migratory capacities, in vitro and in vivo through the PM target gene SERPINB2, which has recently been shown to be involved in multiple stem cell functions. In addition, the PM-induced inhibitory effects on the beneficial functions of endometrial stem cells were significantly diminished by SERPINB2 depletion. Our findings may facilitate the development of promising therapeutic strategies for improving reproductive outcomes in infertile women.

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“…In contrast, few studies were able to demonstrate an association between air pollution and fertility impairment in women, probably due to the multiplicity of factors involved in female reproductive function [15][16][17]. Additionally, little is known regarding the impact of preconceptional exposure to metro area ambient air on early embryo development [16].…”

Section: Introductionmentioning

confidence: 99%

Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET)

Perin

Maluf

Czeresnia

et al. 2010

J Assist Reprod Genet

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Purpose To assess the potential effects of short-term exposure to particulate air pollution during follicular phase on clinical, laboratory, and pregnancy outcomes of women undergoing IVF/ET. Methods Retrospective cohort study of 400 first IVF/ET cycles of women exposed to ambient particulate matter during follicular phase. Particulate matter (PM) was categorized into quartiles (Q 1 : ≤30.48 µg/m 3 , Q 2 : 30.49-42.00 µg/m 3 , Q 3 : 42.01-56.72 µg/m 3 , and Q 4 : >56.72 µg/m 3 ). Results Clinical, laboratory, or treatment variables were not affected by follicular phase PM exposure periods. Women exposed to Q 4 period during the follicular phase of conception cycles had a higher risk of miscarriage (odds ratio, 5.05; 95% confidence interval: 1.04-25.51) when compared to women exposed to Q 1-3 periods. Conclusion Our results show an association between brief exposure to high levels of ambient PM during the preconceptional period and early pregnancy loss, although no effect of this exposure on clinical, laboratory, and treatment outcomes was observed.

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Exposure to traffic pollutants and effects on 17-β-estradiol (E2) in female workers

Cited by 17 publications

References 47 publications

Does air pollution play a role in infertility?: a systematic review

Does air pollution play a role in infertility?: a systematic review

The impact of fine particulate matter (PM) on various beneficial functions of human endometrial stem cells through its key regulator SERPINB2

Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET)

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