The impact of fine particulate matter (PM) on various beneficial functions of human endometrial stem cells through its key regulator SERPINB2

Abstract

Fine particulate matter (PM) has a small diameter but a large surface area; thus, it may have broad toxic effects that subsequently damage many tissues of the human body. Interestingly, many studies have suggested that the recent decline in female fertility could be associated with increased PM exposure. However, the precise mechanisms underlying the negative effects of PM exposure on female fertility are still a matter of debate. A previous study demonstrated that resident stem cell deficiency limits the cyclic regenerative capacity of the endometrium and subsequently increases the pregnancy failure rate. Therefore, we hypothesized that PM exposure induces endometrial tissue damage and subsequently reduces the pregnancy rate by inhibiting various beneficial functions of local endometrial stem cells. Consistent with our hypothesis, we showed for the first time that PM exposure significantly inhibits various beneficial functions of endometrial stem cells, such as their self-renewal, transdifferentiation, and migratory capacities, in vitro and in vivo through the PM target gene SERPINB2, which has recently been shown to be involved in multiple stem cell functions. In addition, the PM-induced inhibitory effects on the beneficial functions of endometrial stem cells were significantly diminished by SERPINB2 depletion. Our findings may facilitate the development of promising therapeutic strategies for improving reproductive outcomes in infertile women.

Addition of oh8dG to Cardioplegia Attenuated Myocardial Oxidative Injury through the Inhibition of Sodium Bicarbonate Cotransporter Activity

“…Ischemia–reperfusion injury-mediated cellular apoptosis is mediated by caspase-3 activation [ 43 ] and, subsequently, induces DNA fragmentation [ 44 ]. Figure 4 a shows an enhanced DAPI staining area that was observed in the HTK-treated cardiomyocytes.…”

Pollution and endometriosis: A deep dive into the environmental impacts on women's health

“…1,[81][82][83] Recent research has shed light on the association between air pollution and endometriosis, revealing the potential adverse effects of airborne contaminants on women's reproductive health. 18,20,84 PM2.5 4,85 and PAHs, 86 two common components of air pollution, have garnered particular attention in relation to endometriosis. PM2.5 refers to tiny particles with a diameter of ≤2.5 microm suspended in the air.…”

“…Signalling pathways related to vascular endothelial growth factor (VEGF) and angiopoietin pathways may also be affected. 85 Moreover, PAH exposure has been associated with the induction of inflammation and immune system responses, such as NF-κB and MAPK pathways. 99 PM2.5 and PAHs contain reactive oxygen species (ROS) that can dysregulate the balance between antioxidants and oxidants in the body.…”

“…PM2.5 4,85 and PAHs, 86 two common components of air pollution, have garnered particular attention in relation to endometriosis. PM2.5 refers to tiny particles with a diameter of ≤2.5 microm suspended in the air.…”

“…PM2.5 can impair endothelial cell function, potentially influencing angiogenesis, the process of forming new blood vessels. Signalling pathways related to vascular endothelial growth factor (VEGF) and angiopoietin pathways may also be affected 85 . Moreover, PAH exposure has been associated with the induction of inflammation and immune system responses, such as NF‐κB and MAPK pathways 99 …”