Exposure to the herbicide 2,4-dichlorophenoxyacetic acid impairs mitochondrial function, oxidative status, and behavior in adult zebrafish

Thiel, Nathana Andressa; Sachett, Adrieli; Schneider, Sabrina Ester; Garbinato, Cristiane; Decui, Laura; Eichwald, Tuany; Conterato, Greicy M. M.; Latini, Alexandra; Piato, Ângelo; Siebel, Anna Maria

doi:10.1007/s11356-020-10497-6

Cited by 18 publications

(1 citation statement)

References 40 publications

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“…The exploratory, locomotor, and anxiety-related parameters studied in the novel tank test are essential for reproduction, predator avoidance, and food-seeking behaviors (Zhang et al 2016). Notably, a study assessing the impact of exposure to the herbicide 2,4-D on zebrafish has observed alterations in both the time spent in the upper zone and the distance traveled, disrupting their natural behavior (Thiel et al 2020). Furthermore, a recent meta-analysis showed that fungicides decrease the locomotion in both zebrafish larvae and adults (Reis et al 2023).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of behavioral and neurochemical changes induced by carbofuran in zebrafish (Danio rerio)

Oliveira,

Gallas-Lopes,

Chitolina

et al. 2024

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Carbofuran (CF) is a carbamate class pesticide, widely used in agriculture for pest control in crops. On the other hand, CF is also detected as a contaminant in food and water sources. This pesticide has high toxicity in non-target organisms, and its presence in the environment poses a threat to the ecosystem. Research has revealed that this pesticide acts as an inhibitor of acetylcholinesterase (AChE), inducing an accumulation of acetylcholine in the brain. Consequently, this leads to the emergence of a cholinergic syndrome and various detrimental effects on human health. Nonetheless, our understanding of CF impact on the central nervous system remains elusive. Therefore, this study aimed to investigate the effects of CF on behavioral and neurochemical parameters in adult zebrafish. The animals were exposed for 96 hours to different concentrations of CF (5, 50, and 500 μg/L) and subjected to behavioral assessments in the novel tank test (NTT) and social preference test (SPT). Subsequently, they were euthanized, and their brains were used to evaluate neurochemical markers associated with oxidative stress and AChE levels. In the NTT and SPT, CF did not alter the evaluated behavioral parameters. Furthermore, CF did not affect the levels of AChE, non-protein sulfhydryl groups, and thiobarbituric acid reactive species in the zebrafish brain. However, further research is needed regarding the environmental exposure of this compound to non-target organisms.

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Section: Discussionmentioning

confidence: 99%